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    SRSF11 serine and arginine rich splicing factor 11 [ Homo sapiens (human) ]

    Gene ID: 9295, updated on 17-Jun-2019

    Summary

    Official Symbol
    SRSF11provided by HGNC
    Official Full Name
    serine and arginine rich splicing factor 11provided by HGNC
    Primary source
    HGNC:HGNC:10782
    See related
    Ensembl:ENSG00000116754 MIM:602010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p54; NET2; SFRS11; dJ677H15.2
    Summary
    This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.[provided by RefSeq, Sep 2010]
    Expression
    Ubiquitous expression in bone marrow (RPKM 46.2), skin (RPKM 32.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See SRSF11 in Genome Data Viewer
    Location:
    1p31.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (70205696..70253052)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (70671365..70717703)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3760 Neighboring gene leucine rich repeat containing 40 Neighboring gene RNA, 7SL, cytoplasmic 242, pseudogene Neighboring gene ankyrin repeat domain 13C Neighboring gene uncharacterized LOC102724548 Neighboring gene HERV-H LTR-associating 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ18226, DKFZp686M13204

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA export from nucleus TAS
    Traceable Author Statement
    more info
     
    RNA splicing TAS
    Traceable Author Statement
    more info
    PubMed 
    mRNA 3'-end processing TAS
    Traceable Author Statement
    more info
     
    mRNA export from nucleus TAS
    Traceable Author Statement
    more info
     
    mRNA processing TAS
    Traceable Author Statement
    more info
    PubMed 
    mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/arginine-rich splicing factor 11
    Names
    SR splicing factor 11
    arginine-rich 54 kDa nuclear protein
    splicing factor p54
    splicing factor, arginine/serine-rich 11

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190987.3NP_001177916.1  serine/arginine-rich splicing factor 11 isoform 2

      See identical proteins and their annotated locations for NP_001177916.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses alternate splice sites in the 3' coding region and 5' UTR, compared to variant 1, and encodes an isoform (2) that is one aa shorter than isoform 1. Variants 2 and 5 encode the same protein (isoform 2).
      Source sequence(s)
      AI002238, AL832279, BC022815, BC040436, BF680379, BG494115, CN294419
      Consensus CDS
      CCDS53332.1
      UniProtKB/Swiss-Prot
      Q05519
      Related
      ENSP00000359989.1, ENST00000370951.5
      Conserved Domains (1) summary
      cd12518
      Location:34113
      RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
    2. NM_001350605.2NP_001337534.1  serine/arginine-rich splicing factor 11 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL832279, BF680379, BG494115, CN294419, DA157431, DC415520, M74002
      Consensus CDS
      CCDS647.1
      Conserved Domains (1) summary
      cd12518
      Location:34113
      RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
    3. NM_001350606.2NP_001337535.1  serine/arginine-rich splicing factor 11 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL832279, BC022815, BF680379, BG494115, CB996573, CN294419, M74002
      Consensus CDS
      CCDS647.1
      Conserved Domains (1) summary
      cd12518
      Location:34113
      RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
    4. NM_001350607.2NP_001337536.1  serine/arginine-rich splicing factor 11 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL832279, BC022815, BC040436, BF680379, BG494115, CN294419, M74002
      Consensus CDS
      CCDS53332.1
      Conserved Domains (1) summary
      cd12518
      Location:34113
      RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
    5. NM_001350608.2NP_001337537.1  serine/arginine-rich splicing factor 11 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL832279, BC022815, BF680379, BG494115, CN294419, CX869063, M74002
      Conserved Domains (1) summary
      cd12518
      Location:34113
      RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
    6. NM_001350609.2NP_001337538.1  serine/arginine-rich splicing factor 11 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL832279, BC022815, BF680379, BG494115, BG612368, CB996573, CN294419, CX869063, M74002
      Conserved Domains (1) summary
      cd12518
      Location:34113
      RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
    7. NM_001350610.2NP_001337539.1  serine/arginine-rich splicing factor 11 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL353771, BF680379, BG494115, BM716576, BP290987, CA417788, CN294419, CX869063, DA157431, DA581964, DC415520
    8. NM_001350611.2NP_001337540.1  serine/arginine-rich splicing factor 11 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, BP290987, CA417788, CN294419, CX869063, DA157431, DA581964, DC415520
    9. NM_001350612.2NP_001337541.1  serine/arginine-rich splicing factor 11 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, CA417788, CN294419, DA157431, DA581964, DC415520
    10. NM_001350613.2NP_001337542.1  serine/arginine-rich splicing factor 11 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, CA417788, CN294419, DA157431, DA581964, DC415520
    11. NM_001350614.2NP_001337543.1  serine/arginine-rich splicing factor 11 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, BP290987, CA417788, CN294419, DA157431, DA581964, DC415520
    12. NM_001350615.2NP_001337544.1  serine/arginine-rich splicing factor 11 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, BP290987, CA417788, CN294419, CX869063, DA157431, DA581964, DC415520
    13. NM_001350616.2NP_001337545.1  serine/arginine-rich splicing factor 11 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, BP290987, CA417788, CN294419, DA157431, DA581964, DC415520
    14. NM_004768.5NP_004759.1  serine/arginine-rich splicing factor 11 isoform 1

      See identical proteins and their annotated locations for NP_004759.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 3, and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AI002238, AL832279, BC022815, BF680379, BG494115, CN294419, M74002
      Consensus CDS
      CCDS647.1
      UniProtKB/Swiss-Prot
      Q05519
      Related
      ENSP00000359988.3, ENST00000370950.7
      Conserved Domains (1) summary
      cd12518
      Location:34113
      RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

    RNA

    1. NR_146810.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL832279, BF680379, BG494115, BP290987, CD687855, CN294419, DA157431, DC415520, M74002

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      70205696..70253052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542431.2XP_011540733.1  serine/arginine-rich splicing factor 11 isoform X2

      See identical proteins and their annotated locations for XP_011540733.1

    2. XM_005271338.4XP_005271395.1  serine/arginine-rich splicing factor 11 isoform X1

      See identical proteins and their annotated locations for XP_005271395.1

      Conserved Domains (1) summary
      cd12518
      Location:34113
      RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
    3. XM_024450905.1XP_024306673.1  serine/arginine-rich splicing factor 11 isoform X1

      Conserved Domains (1) summary
      cd12518
      Location:34113
      RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
    4. XM_024450912.1XP_024306680.1  serine/arginine-rich splicing factor 11 isoform X3

      Related
      ENSP00000359987.1, ENST00000370949.1
    5. XM_017002819.2XP_016858308.1  serine/arginine-rich splicing factor 11 isoform X5

    6. XM_024450906.1XP_024306674.1  serine/arginine-rich splicing factor 11 isoform X2

    7. XM_011542428.3XP_011540730.1  serine/arginine-rich splicing factor 11 isoform X2

      See identical proteins and their annotated locations for XP_011540730.1

    8. XM_024450908.1XP_024306676.1  serine/arginine-rich splicing factor 11 isoform X3

    9. XM_024450917.1XP_024306685.1  serine/arginine-rich splicing factor 11 isoform X5

    10. XM_017002820.2XP_016858309.1  serine/arginine-rich splicing factor 11 isoform X6

    11. XM_024450922.1XP_024306690.1  serine/arginine-rich splicing factor 11 isoform X7

    12. XM_024450927.1XP_024306695.1  serine/arginine-rich splicing factor 11 isoform X8

    13. XM_017002815.2XP_016858304.1  serine/arginine-rich splicing factor 11 isoform X2

    14. XM_017002817.2XP_016858306.1  serine/arginine-rich splicing factor 11 isoform X5

    15. XM_017002825.2XP_016858314.1  serine/arginine-rich splicing factor 11 isoform X7

    16. XM_017002831.2XP_016858320.1  serine/arginine-rich splicing factor 11 isoform X8

    17. XM_024450923.1XP_024306691.1  serine/arginine-rich splicing factor 11 isoform X7

    18. XM_024450916.1XP_024306684.1  serine/arginine-rich splicing factor 11 isoform X5

    19. XM_024450921.1XP_024306689.1  serine/arginine-rich splicing factor 11 isoform X7

    20. XM_024450925.1XP_024306693.1  serine/arginine-rich splicing factor 11 isoform X8

    21. XM_024450915.1XP_024306683.1  serine/arginine-rich splicing factor 11 isoform X4

    RNA

    1. XR_426640.4 RNA Sequence

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