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    TBRG4 transforming growth factor beta regulator 4 [ Homo sapiens (human) ]

    Gene ID: 9238, updated on 3-Nov-2024

    Summary

    Official Symbol
    TBRG4provided by HGNC
    Official Full Name
    transforming growth factor beta regulator 4provided by HGNC
    Primary source
    HGNC:HGNC:17443
    See related
    Ensembl:ENSG00000136270 MIM:611325; AllianceGenome:HGNC:17443
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPR2; FASTKD4
    Summary
    Enables RNA binding activity. Involved in mitochondrial mRNA processing and regulation of mitochondrial mRNA stability. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 18.2), duodenum (RPKM 14.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TBRG4 in Genome Data Viewer
    Location:
    7p13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (45100100..45111697, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (45260901..45272500, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (45139699..45151296, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18162 Neighboring gene CCM2 scaffold protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45112087-45112746 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45112747-45113406 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_99227 Neighboring gene NAC alpha domain containing Neighboring gene ReSE screen-validated silencer GRCh37_chr7:45143162-45143329 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45151068-45151823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18164 Neighboring gene small nucleolar RNA, H/ACA box 5A Neighboring gene small nucleolar RNA, H/ACA box 5C Neighboring gene small nucleolar RNA, H/ACA box 5B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:45163452-45164277 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:45173420-45173920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25970 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:45217100-45217600 Neighboring gene receptor activity modifying protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:45230075-45230721 Neighboring gene uncharacterized LOC124901623 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25971

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with transforming growth factor beta regulator 4 (TBRG4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0948

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    FAST kinase domain-containing protein 4
    Names
    FAST kinase domains 4
    H_TD2522F11.8
    cell cycle progression protein 2
    cell cycle progression restoration protein 2
    protein TBRG4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261834.2NP_001248763.1  FAST kinase domain-containing protein 4 isoform 3

      See identical proteins and their annotated locations for NP_001248763.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' region and initiates translation at an upstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a longer N-terminus, compared to isoform 1.
      Source sequence(s)
      AK298155, AK300489, BM150942
      UniProtKB/TrEMBL
      B4DU42
      Conserved Domains (3) summary
      smart00952
      Location:574631
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:381447
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:465546
      FAST_2; FAST kinase-like protein, subdomain 2
    2. NM_004749.4NP_004740.2  FAST kinase domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_004740.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      BC017235, BM150942, DA980367
      Consensus CDS
      CCDS5501.1
      UniProtKB/Swiss-Prot
      A4D2L2, A4D2L3, D3DVL5, D3DVL6, O14710, Q53GI8, Q8NDM4, Q969Z0, Q9BUC6, Q9Y2F6
      Related
      ENSP00000258770.3, ENST00000258770.8
      Conserved Domains (3) summary
      smart00952
      Location:563620
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:370436
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:454535
      FAST_2; FAST kinase-like protein, subdomain 2
    3. NM_030900.4NP_112162.1  FAST kinase domain-containing protein 4 isoform 2

      See identical proteins and their annotated locations for NP_112162.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which is shorter than isoform 1.
      Source sequence(s)
      AB023165, AK222943, BM150942, DA980367
      Consensus CDS
      CCDS5502.1
      UniProtKB/TrEMBL
      B3KM73
      Related
      ENSP00000354992.3, ENST00000361278.7
      Conserved Domains (3) summary
      smart00952
      Location:453510
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:260326
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:344425
      FAST_2; FAST kinase-like protein, subdomain 2
    4. NM_199122.3NP_954573.1  FAST kinase domain-containing protein 4 isoform 2

      See identical proteins and their annotated locations for NP_954573.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which is shorter than isoform 1.
      Source sequence(s)
      AK001281, BM150942
      Consensus CDS
      CCDS5502.1
      UniProtKB/TrEMBL
      B3KM73
      Related
      ENSP00000379016.4, ENST00000395655.8
      Conserved Domains (3) summary
      smart00952
      Location:453510
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:260326
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:344425
      FAST_2; FAST kinase-like protein, subdomain 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      45100100..45111697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      45260901..45272500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)