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    METTL18 methyltransferase 18, RPL3 N3(tau)-histidine [ Homo sapiens (human) ]

    Gene ID: 92342, updated on 18-Sep-2024

    Summary

    Official Symbol
    METTL18provided by HGNC
    Official Full Name
    methyltransferase 18, RPL3 N3(tau)-histidineprovided by HGNC
    Primary source
    HGNC:HGNC:28793
    See related
    Ensembl:ENSG00000171806 MIM:615255; AllianceGenome:HGNC:28793
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HPM1; AsTP2; C1orf156
    Summary
    Enables heat shock protein binding activity and protein-L-histidine N-tele-methyltransferase activity. Involved in peptidyl-lysine monomethylation; regulation of gene expression; and regulation of ribosome biogenesis. Located in cytosol and nucleolus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lymph node (RPKM 4.6), thyroid (RPKM 3.3) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See METTL18 in Genome Data Viewer
    Location:
    1q24.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (169792529..169794907, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (169148308..169150686, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (169761670..169764048, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene selectin E Neighboring gene uncharacterized LOC101928628 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:169751147-169751648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2079 Neighboring gene FIGNL1 interacting regulator of recombination and mitosis Neighboring gene MPRA-validated peak450 silencer Neighboring gene RNA, 7SL, cytoplasmic 333, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2080 Neighboring gene SCY1 like pseudokinase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:169862205-169862792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:169862793-169863380 Neighboring gene VISTA enhancer hs1442 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:169914181-169914349 Neighboring gene kinesin associated protein 3 Neighboring gene RNA, 7SL, cytoplasmic 269, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC9084

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-L-histidine N-tele-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-L-histidine N-tele-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-lysine monomethylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of ribosome biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of translational elongation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histidine protein methyltransferase 1 homolog
    Names
    arsenic-transactivated protein 2
    methyltransferase 18, RPL3 N3-histidine
    methyltransferase like 18
    methyltransferase-like protein 18
    NP_001307128.1
    NP_001307130.1
    NP_219486.1
    XP_006711690.1
    XP_054195593.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320199.2NP_001307128.1  histidine protein methyltransferase 1 homolog

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      BC008679, BG614785, HY159746
      Consensus CDS
      CCDS1284.1
      UniProtKB/Swiss-Prot
      B2R9T5, O95568
      Conserved Domains (1) summary
      cl17173
      Location:165324
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001320201.2NP_001307130.1  histidine protein methyltransferase 1 homolog

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      BC008679
      Consensus CDS
      CCDS1284.1
      UniProtKB/Swiss-Prot
      B2R9T5, O95568
      Related
      ENSP00000307077.2, ENST00000303469.6
      Conserved Domains (1) summary
      cl17173
      Location:165324
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. NM_033418.4NP_219486.1  histidine protein methyltransferase 1 homolog

      See identical proteins and their annotated locations for NP_219486.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      BC008679, HY159746
      Consensus CDS
      CCDS1284.1
      UniProtKB/Swiss-Prot
      B2R9T5, O95568
      Related
      ENSP00000307975.4, ENST00000310392.5
      Conserved Domains (1) summary
      cl17173
      Location:165324
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      169792529..169794907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006711627.4XP_006711690.1  histidine protein methyltransferase 1 homolog isoform X1

      See identical proteins and their annotated locations for XP_006711690.1

      UniProtKB/Swiss-Prot
      B2R9T5, O95568
      Conserved Domains (1) summary
      cl17173
      Location:165324
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      169148308..169150686 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339618.1XP_054195593.1  histidine protein methyltransferase 1 homolog isoform X1