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    DUSP27 dual specificity phosphatase 27, atypical [ Homo sapiens (human) ]

    Gene ID: 92235, updated on 17-Jun-2019

    Summary

    Official Symbol
    DUSP27provided by HGNC
    Official Full Name
    dual specificity phosphatase 27, atypicalprovided by HGNC
    Primary source
    HGNC:HGNC:25034
    See related
    Ensembl:ENSG00000198842
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in heart (RPKM 26.2) and prostate (RPKM 2.1) See more
    Orthologs

    Genomic context

    See DUSP27 in Genome Data Viewer
    Location:
    1q24.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (167094048..167129165)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (167063314..167098402)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371600 Neighboring gene glycoprotein A33 Neighboring gene uncharacterized LOC105371598 Neighboring gene uncharacterized LOC105371601 Neighboring gene ribosomal protein S17 pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    sarcomere IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    inactive dual specificity phosphatase 27
    Names
    dual specificity phosphatase 27 (putative)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080426.3NP_001073895.1  inactive dual specificity phosphatase 27

      See identical proteins and their annotated locations for NP_001073895.1

      Status: VALIDATED

      Source sequence(s)
      AL158837
      Consensus CDS
      CCDS30932.1
      UniProtKB/Swiss-Prot
      Q5VZP5
      Related
      ENSP00000354483.2, ENST00000361200.6
      Conserved Domains (1) summary
      cd00127
      Location:133275
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      167094048..167129165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510146.2XP_011508448.1  inactive dual specificity phosphatase 27 isoform X1

      Conserved Domains (1) summary
      cd00127
      Location:94236
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
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