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    FCMR Fc mu receptor [ Homo sapiens (human) ]

    Gene ID: 9214, updated on 3-Apr-2024

    Summary

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    Official Symbol
    FCMRprovided by HGNC
    Official Full Name
    Fc mu receptorprovided by HGNC
    Primary source
    HGNC:HGNC:14315
    See related
    Ensembl:ENSG00000162894 MIM:606015; AllianceGenome:HGNC:14315
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TOSO; FAIM3; FcmuR; IgM FcR
    Summary
    Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]
    Expression
    Biased expression in lymph node (RPKM 59.4), spleen (RPKM 52.0) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FCMR in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (206903317..206923196, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (206167622..206187486, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207076662..207095286, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene interleukin 20 Neighboring gene uncharacterized LOC105372879 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207063449-207064648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2426 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:207078063-207079262 Neighboring gene interleukin 24 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1768 Neighboring gene negCOR silencer S10 Neighboring gene ribosomal protein L13a pseudogene 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:207103683-207104183 Neighboring gene polymeric immunoglobulin receptor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1769 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207134913-207136112 Neighboring gene Fc alpha and mu receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Mapping of the binding site for FcμR in human IgM-Fc. Nyamboya RA, et al. Biochim Biophys Acta Proteins Proteom, 2020 Jan. PMID 31449905, Free PMC Article
    2. Toso, a functional IgM receptor, is regulated by IL-2 in T and NK cells. Murakami Y, et al. J Immunol, 2012 Jul 15. PMID 22675200, Free PMC Article
    3. TOSO, the Fcmicro receptor, is highly expressed on chronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation. Vire B, et al. J Immunol, 2011 Oct 15. PMID 21908732, Free PMC Article
    4. Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (FcμR) in patients with chronic lymphocytic leukemia. Li FJ, et al. Blood, 2011 Nov 3. PMID 21908424, Free PMC Article
    5. [Expression and prognostic significance of TOSO in CD19+ B cells from Chinese CLL patients]. Yu Z, et al. Zhonghua Yi Xue Za Zhi, 2011 May 31. PMID 21756805

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Differences between Human and Mouse IgM Fc Receptor (FcmicroR).
      Title: Differences between Human and Mouse IgM Fc Receptor (FcµR).
    2. TOSO interacts with SYK and enhances BCR pathway activation in chronic lymphocytic leukemia.
      Title: TOSO interacts with SYK and enhances BCR pathway activation in chronic lymphocytic leukemia.
    3. TGIF2 promotes cervical cancer metastasis by negatively regulating FCMR.
      Title: TGIF2 promotes cervical cancer metastasis by negatively regulating FCMR.
    4. We conclude that glutamine at position 510 in Cmu4 is critical for IgM binding to FcmuR. This will facilitate discrimination between the distinct effects of FcmuR interactions with soluble IgM and with the IgM BCR.
      Title: Mapping of the binding site for FcμR in human IgM-Fc.
    5. Overexpression of TOSO gene is associated with chronic lymphocytic leukemia.
      Title: Overexpression of Fc mu receptor (FCMR, TOSO) gene in chronic lymphocytic leukemia patients.
    6. Toso/FcmuR is an IgM receptor capable of activating signaling molecules and whose expression alone is not inherently antiapoptotic.
      Title: Toso, a functional IgM receptor, is regulated by IL-2 in T and NK cells.
    7. Overexpression of TOSO in chronic lymphocytic leukemia is associated with disease progression.
      Title: [Expression and prognostic significance of TOSO in CD19+ B cells from Chinese CLL patients].
    8. Enhanced levels of both membrane-bound and soluble forms of FcmuR in CLL patients.
      Title: Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (FcμR) in patients with chronic lymphocytic leukemia.
    9. TOSO/FAIM3 may play a role in immune surveillance and contribute to B cell activation
      Title: TOSO, the Fcmicro receptor, is highly expressed on chronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation.
    10. we demonstrate that the immune specific cell surface molecule Toso exhibits antiapoptotic effects on death receptor signaling by a novel regulatory mechanism involving the adaptor kinase RIP1
      Title: Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables IgM binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables high-affinity IgM receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polymeric immunoglobulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Fc receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Fc receptor-mediated immune complex endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in humoral immune response mediated by circulating immunoglobulin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in immunoglobulin transcytosis in epithelial cells ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of B cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    immunoglobulin mu Fc receptor; fas apoptotic inhibitory molecule 3
    Names
    Fas apoptotic inhibitory molecule 3
    Fc fragment of IgM receptor
    IgM Fc fragment receptor
    IgM Fc receptor
    regulator of Fas-induced apoptosis Toso

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142473.2 → NP_001135945.1  immunoglobulin mu Fc receptor isoform b

      See identical proteins and their annotated locations for NP_001135945.1

      Status: VALIDATED

      Source sequence(s)
      AA769146, AI524407, BC006401, BP305798, BP338035, CB158779, DA971987
      Consensus CDS
      CCDS44304.1
      UniProtKB/TrEMBL
      B7Z497
      Related
      ENSP00000404136.2, ENST00000442471.4

    2. NM_001193338.2 → NP_001180267.1  immunoglobulin mu Fc receptor isoform c precursor

      See identical proteins and their annotated locations for NP_001180267.1

      Status: VALIDATED

      Source sequence(s)
      AC098935, AI524407, BC006401, HM480394
      Consensus CDS
      CCDS53467.1
      UniProtKB/Swiss-Prot
      O60667
      Related
      ENSP00000485739.1, ENST00000628511.2
      Conserved Domains (2) summary
      cd05716
      Location:24 → 121
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:25 → 122
      IG_like; Immunoglobulin like

    3. NM_001405862.1 → NP_001392791.1  immunoglobulin mu Fc receptor isoform d

      Status: VALIDATED

      Source sequence(s)
      AC098935

    4. NM_001405863.1 → NP_001392792.1  immunoglobulin mu Fc receptor isoform d

      Status: VALIDATED

      Source sequence(s)
      AC098935

    5. NM_001405864.1 → NP_001392793.1  immunoglobulin mu Fc receptor isoform e precursor

      Status: VALIDATED

      Source sequence(s)
      AC098935

    6. NM_001405865.1 → NP_001392794.1  immunoglobulin mu Fc receptor isoform e precursor

      Status: VALIDATED

      Source sequence(s)
      AC098935

    7. NM_001405866.1 → NP_001392795.1  immunoglobulin mu Fc receptor isoform f precursor

      Status: VALIDATED

      Source sequence(s)
      AC098935

    8. NM_001405867.1 → NP_001392796.1  immunoglobulin mu Fc receptor isoform g precursor

      Status: VALIDATED

      Source sequence(s)
      AC098935

    9. NM_001405868.1 → NP_001392797.1  immunoglobulin mu Fc receptor isoform g precursor

      Status: VALIDATED

      Source sequence(s)
      AC098935

    10. NM_001405871.1 → NP_001392800.1  immunoglobulin mu Fc receptor isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC098935
      UniProtKB/Swiss-Prot
      A8K7J2, B7Z6Z0, D9MWM3, O60667

    11. NM_001405886.1 → NP_001392815.1  immunoglobulin mu Fc receptor isoform h

      Status: VALIDATED

      Source sequence(s)
      AC098935

    12. NM_001405887.1 → NP_001392816.1  immunoglobulin mu Fc receptor isoform b

      Status: VALIDATED

      Source sequence(s)
      AC098935

    13. NM_001405888.1 → NP_001392817.1  immunoglobulin mu Fc receptor isoform j

      Status: VALIDATED

      Source sequence(s)
      AC098935

    14. NM_001405889.1 → NP_001392818.1  immunoglobulin mu Fc receptor isoform k precursor

      Status: VALIDATED

      Source sequence(s)
      AC098935

    15. NM_001405890.1 → NP_001392819.1  immunoglobulin mu Fc receptor isoform l

      Status: VALIDATED

      Source sequence(s)
      AC098935

    16. NM_001405891.1 → NP_001392820.1  immunoglobulin mu Fc receptor isoform m

      Status: VALIDATED

      Source sequence(s)
      AC098935

    17. NM_001405892.1 → NP_001392821.1  immunoglobulin mu Fc receptor isoform n precursor

      Status: VALIDATED

      Source sequence(s)
      AC098935

    18. NM_005449.5 → NP_005440.1  immunoglobulin mu Fc receptor isoform a precursor

      See identical proteins and their annotated locations for NP_005440.1

      Status: VALIDATED

      Source sequence(s)
      AA769146, AI524407, BC006401, BP338035, CB158779
      Consensus CDS
      CCDS1473.1
      UniProtKB/Swiss-Prot
      A8K7J2, B7Z6Z0, D9MWM3, O60667
      Related
      ENSP00000356058.3, ENST00000367091.8
      Conserved Domains (2) summary
      cd05716
      Location:24 → 121
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:25 → 122
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      206903317..206923196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434331.1 → XP_047290287.1  fas apoptotic inhibitory molecule 3 isoform X1

    2. XM_047434334.1 → XP_047290290.1  fas apoptotic inhibitory molecule 3 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      206167622..206187486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339614.1 → XP_054195589.1  fas apoptotic inhibitory molecule 3 isoform X1

    2. XM_054339615.1 → XP_054195590.1  fas apoptotic inhibitory molecule 3 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001142472.1: Suppressed sequence

      Description
      NM_001142472.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60667.1 GenPept UniProtKB/Swiss-Prot:O60667

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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