AURKB aurora kinase B [Homo sapiens (human)] - Gene

Summary

Official Symbol: AURKBprovided by HGNC
Official Full Name: aurora kinase Bprovided by HGNC
Primary source: HGNC:HGNC:11390
See related: Ensembl:ENSG00000178999 MIM:604970
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; ARK-2; STK-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2
Summary: This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
Expression: Biased expression in lymph node (RPKM 11.6), bone marrow (RPKM 10.7) and 11 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17p13.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109.20210514	current	GRCh38.p13 (GCF_000001405.39)	17	NC_000017.11 (8204731..8210767, complement)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (8108049..8113893, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

USP48 Governs Cell Cycle Progression by Regulating the Protein Level of Aurora B.
Title: USP48 Governs Cell Cycle Progression by Regulating the Protein Level of Aurora B.
Chromosomal localization of Ewing sarcoma EWSR1/FLI1 protein promotes the induction of aneuploidy.
Title: Chromosomal localization of Ewing sarcoma EWSR1/FLI1 protein promotes the induction of aneuploidy.
Expression and clinical significance of AURKB gene in lung adenocarcinoma: Analysis based on the data-mining of bioinformatic database.
Title: Expression and clinical significance of AURKB gene in lung adenocarcinoma: Analysis based on the data-mining of bioinformatic database.
Aurora B kinase: a potential drug target for cancer therapy.
Title: Aurora B kinase: a potential drug target for cancer therapy.
Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.
Title: Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.
Heteroarene-fused anthraquinone derivatives as potential modulators for human aurora kinase B.
Title: Heteroarene-fused anthraquinone derivatives as potential modulators for human aurora kinase B.
MicroRNA Let-7c Contributes to Paclitaxel Resistance via Aurora-B in Endometrial Serous Carcinoma.
Title: MicroRNA Let-7c Contributes to Paclitaxel Resistance via Aurora-B in Endometrial Serous Carcinoma.
Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction.
Title: Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction.
HI-511 overcomes melanoma drug resistance via targeting AURKB and BRAF V600E.
Title: HI-511 overcomes melanoma drug resistance <i>via</i> targeting AURKB and BRAF V600E.
Loss of Aurora Kinase Signaling Allows Lung Cancer Cells to Adopt Endoreplication and Form Polyploid Giant Cancer Cells That Resist Antimitotic Drugs.
Title: Loss of Aurora Kinase Signaling Allows Lung Cancer Cells to Adopt Endoreplication and Form Polyploid Giant Cancer Cells That Resist Antimitotic Drugs.

Submit: New GeneRIF Correction See all GeneRIFs (335)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	HIV-1 Vpr upregulates AURKB in HeLa cells within 12 hours of exposure	PubMed
	vpr	AurB and INCENP proteins targeting the inner centromere are reduced significantly in HIV-1 Vpr-expressing prometaphase cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH17506 (e-PCR)
- UniSTS:43328

SGC34636 (e-PCR)
- UniSTS:150

Homology

Homologs of the AURKB gene: The AURKB gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.
Orthologs from Annotation Pipeline: 182 organisms have orthologs with human gene AURKB
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone serine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables histone serine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables protein serine/threonine/tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in abscission	ISS Inferred from Sequence or Structural Similarity more info
involved_in aging	IEA Inferred from Electronic Annotation more info
involved_in attachment of spindle microtubules to kinetochore	TAS Traceable Author Statement more info	PubMed
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV	IDA Inferred from Direct Assay more info	PubMed
involved_in cleavage furrow formation	IDA Inferred from Direct Assay more info	PubMed
involved_in histone H3-S28 phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in histone modification	TAS Traceable Author Statement more info	PubMed
involved_in mitotic cytokinesis checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle assembly checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle midzone assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle midzone assembly	TAS Traceable Author Statement more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of B cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokinesis	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of telomerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of telomere capping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of telomere maintenance via telomerase	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in protein localization to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of chromosome segregation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of signal transduction by p53 class mediator	TAS Traceable Author Statement more info
involved_in spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromocenter	IEA Inferred from Electronic Annotation more info
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of chromosome passenger complex	IPI Inferred from Physical Interaction more info	PubMed
part_of chromosome passenger complex	TAS Traceable Author Statement more info	PubMed
located_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	TAS Traceable Author Statement more info	PubMed
located_in mitotic spindle midzone	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle pole	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	TAS Traceable Author Statement more info	PubMed
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in spindle pole centrosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: aurora kinase B

Names: aurora kinase B-Sv1; aurora kinase B-Sv2; aurora- and Ipl1-like midbody-associated protein 1; aurora-1; aurora-B; aurora-related kinase 2; aurora/IPL1-related kinase 2; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase 12; serine/threonine-protein kinase 12; serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B

NP_001243763.1

EC 2.7.11.1

NP_001271455.1

EC 2.7.11.1

NP_001300879.1

EC 2.7.11.1

NP_001300880.1

EC 2.7.11.1

NP_001300881.1

EC 2.7.11.1

NP_001300882.1

EC 2.7.11.1

NP_001300883.1

EC 2.7.11.1

NP_001300884.1

EC 2.7.11.1

NP_004208.2

EC 2.7.11.1

XP_011522374.1

EC 2.7.11.1

XP_016880796.1

EC 2.7.11.1

XP_016880797.1

EC 2.7.11.1

XP_016880798.1

EC 2.7.11.1

XP_016880799.1

EC 2.7.11.1

XP_016880800.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256834.3 → NP_001243763.1 aurora kinase B isoform 2

See identical proteins and their annotated locations for NP_001243763.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' coding region, which results in translation initiation from an in-frame downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 5 encode the same isoform.

Source sequence(s)

AK297976, BC009751

Consensus CDS

CCDS58514.1

UniProtKB/Swiss-Prot

Q96GD4

Related

ENSP00000443869.1, ENST00000534871.5

Conserved Domains (2) summary

smart00220
Location:36 → 286

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:29 → 298

PKc_like; Protein Kinases, catalytic domain
NM_001284526.2 → NP_001271455.1 aurora kinase B isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame acceptor splice site in the mid-coding region compared to variant 1. The resulting isoform (3) is one amino acid longer than isoform 1.

Source sequence(s)

BC009751, BC013300

Consensus CDS

CCDS67162.1

UniProtKB/Swiss-Prot

Q96GD4

Related

ENSP00000313950.6, ENST00000316199.10

Conserved Domains (2) summary

smart00220
Location:78 → 328

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:71 → 340

PKc_like; Protein Kinases, catalytic domain
NM_001313950.2 → NP_001300879.1 aurora kinase B isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate acceptor splice site in the 5' non-coding region compared to variant 1. Variants 4 and 1 encode the same isoform (1).

Source sequence(s)

BC009751, BP225027, CX781462

Consensus CDS

CCDS11134.1

UniProtKB/Swiss-Prot

Q96GD4

Conserved Domains (1) summary

cl21453
Location:70 → 339

PKc_like; Protein Kinases, catalytic domain
NM_001313951.1 → NP_001300880.1 aurora kinase B isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (5) contains a novel exon in the 5' region, which results in translation initiation from an in-frame downstream start codon compared to variant 1. Variants 5 and 2 encode the same isoform (2).

Source sequence(s)

BC009751, BE797606, BP225027

Consensus CDS

CCDS58514.1

UniProtKB/Swiss-Prot

Q96GD4

Conserved Domains (2) summary

smart00220
Location:36 → 286

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:29 → 298

PKc_like; Protein Kinases, catalytic domain
NM_001313952.2 → NP_001300881.1 aurora kinase B isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an exon in the 5' coding region and uses two alternate acceptor splice sites in the mid-region compared to variant 1. The encoded isoform (4), resulting from use of an in-frame downstream start codon, has a shorter N-terminus and and an extra amino acid in the mid-region compared to isoform 1.

Source sequence(s)

BC009751, BM905813, BP225027

UniProtKB/Swiss-Prot

Q96GD4

Conserved Domains (2) summary

smart00220
Location:37 → 287

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:30 → 299

PKc_like; Protein Kinases, catalytic domain
NM_001313953.3 → NP_001300882.1 aurora kinase B isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (7) uses alternate in-frame donor and acceptor splices sites in the mid-coding region compared to variant 1. The resulting isoform (5) is shorter containing a 16 aa protein segment not found in isoform 1.

Source sequence(s)

AC135178, BC009751, BU153790

Consensus CDS

CCDS82065.1

UniProtKB/Swiss-Prot

Q96GD4

Related

ENSP00000462207.1, ENST00000578549.5

Conserved Domains (2) summary

smart00220
Location:102 → 295

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:70 → 307

PKc_like; Protein Kinases, catalytic domain
NM_001313954.2 → NP_001300883.1 aurora kinase B isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (8) uses an alternate donor splice site in the mid-region compared to variant 1. It represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render this transcript variant a candidate for nonsense-mediated mRNA decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which would result in an isoform (6) that is shorter, with a distinct N-terminus compared to isoform 1.

Source sequence(s)

AF004022, BC009751, BP225027, BU181480

UniProtKB/Swiss-Prot

Q96GD4

Conserved Domains (2) summary

smart00220
Location:27 → 175

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:21 → 187

PKc_like; Protein Kinases, catalytic domain
NM_001313955.2 → NP_001300884.1 aurora kinase B isoform 7

Status: REVIEWED

Description

Transcript Variant: This variant (9) lacks two non-consecutive exons in the 5' and mid-region and uses an alternate donor splice site in the mid-region, compared to variant 1. It represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render this transcript variant a candidate for nonsense-mediated mRNA decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which would result in an isoform (7) that is shorter, with a distinct N-terminus compared to isoform 1.

Source sequence(s)

BC009751, BI199088, BP225027

UniProtKB/Swiss-Prot

Q96GD4

Conserved Domains (2) summary

smart00220
Location:10 → 159

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:10 → 171

PKc_like; Protein Kinases, catalytic domain
NM_004217.4 → NP_004208.2 aurora kinase B isoform 1

See identical proteins and their annotated locations for NP_004208.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes the predominant isoform (1). Variants 1 and 4 encode the same isoform.

Source sequence(s)

AC135178, BC000442, BC009751

Consensus CDS

CCDS11134.1

UniProtKB/Swiss-Prot

Q96GD4

Related

ENSP00000463999.1, ENST00000585124.6

Conserved Domains (1) summary

cl21453
Location:70 → 339

PKc_like; Protein Kinases, catalytic domain

RNA

NR_132730.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (10) uses an alternate donor splice site in the mid-region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript variant a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BC009751, CN286704
NR_132731.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (11) lacks an internal exon and uses an alternate acceptor splice site in the mid-region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript variant a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AY677083, BC009751

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p13 Primary Assembly

Range

8204731..8210767 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017025307.2 → XP_016880796.1 aurora kinase B isoform X1

UniProtKB/Swiss-Prot

Q96GD4

Conserved Domains (2) summary

smart00220
Location:36 → 286

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:29 → 298

PKc_like; Protein Kinases, catalytic domain
XM_017025308.2 → XP_016880797.1 aurora kinase B isoform X2
XM_011524072.3 → XP_011522374.1 aurora kinase B isoform X1

See identical proteins and their annotated locations for XP_011522374.1

UniProtKB/Swiss-Prot

Q96GD4

Conserved Domains (2) summary

smart00220
Location:36 → 286

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:29 → 298

PKc_like; Protein Kinases, catalytic domain
XM_017025310.1 → XP_016880799.1 aurora kinase B isoform X3

Conserved Domains (2) summary

smart00220
Location:27 → 175

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:21 → 187

PKc_like; Protein Kinases, catalytic domain
XM_017025309.1 → XP_016880798.1 aurora kinase B isoform X3

Conserved Domains (2) summary

smart00220
Location:27 → 175

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:21 → 187

PKc_like; Protein Kinases, catalytic domain
XM_017025311.1 → XP_016880800.1 aurora kinase B isoform X3

Conserved Domains (2) summary

smart00220
Location:27 → 175

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:21 → 187

PKc_like; Protein Kinases, catalytic domain