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    AURKB aurora kinase B [ Homo sapiens (human) ]

    Gene ID: 9212, updated on 19-Sep-2021

    Summary

    Official Symbol
    AURKBprovided by HGNC
    Official Full Name
    aurora kinase Bprovided by HGNC
    Primary source
    HGNC:HGNC:11390
    See related
    Ensembl:ENSG00000178999 MIM:604970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; ARK-2; STK-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2
    Summary
    This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in lymph node (RPKM 11.6), bone marrow (RPKM 10.7) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See AURKB in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (8204731..8210767, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8108049..8113893, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene BLOC-1 related complex subunit 6 Neighboring gene nonconserved acetylation island sequence 72 enhancer Neighboring gene tRNA-Trp (anticodon CCA) 1-1 Neighboring gene long intergenic non-protein coding RNA 324 Neighboring gene tRNA-Gly (anticodon TCC) 3-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr upregulates AURKB in HeLa cells within 12 hours of exposure PubMed
    vpr AurB and INCENP proteins targeting the inner centromere are reduced significantly in HIV-1 Vpr-expressing prometaphase cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone serine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone serine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables protein serine/threonine/tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in abscission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in aging IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in attachment of spindle microtubules to kinetochore TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cleavage furrow formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histone H3-S28 phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in histone modification TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mitotic cytokinesis checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic spindle assembly checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic spindle midzone assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic spindle midzone assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of B cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytokinesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of telomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of telomere capping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein localization to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of chromosome segregation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of signal transduction by p53 class mediator TAS
    Traceable Author Statement
    more info
     
    involved_in spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromocenter IEA
    Inferred from Electronic Annotation
    more info
     
    part_of chromosome passenger complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of chromosome passenger complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of chromosome passenger complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in midbody TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in mitotic spindle midzone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle pole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in spindle pole centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    aurora kinase B
    Names
    aurora kinase B-Sv1
    aurora kinase B-Sv2
    aurora- and Ipl1-like midbody-associated protein 1
    aurora-1
    aurora-B
    aurora-related kinase 2
    aurora/IPL1-related kinase 2
    protein phosphatase 1, regulatory subunit 48
    serine/threonine kinase 12
    serine/threonine-protein kinase 12
    serine/threonine-protein kinase 5
    serine/threonine-protein kinase aurora-B
    NP_001243763.1
    NP_001271455.1
    NP_001300879.1
    NP_001300880.1
    NP_001300881.1
    NP_001300882.1
    NP_001300883.1
    NP_001300884.1
    NP_004208.2
    XP_011522374.1
    XP_016880796.1
    XP_016880797.1
    XP_016880798.1
    XP_016880799.1
    XP_016880800.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256834.3NP_001243763.1  aurora kinase B isoform 2

      See identical proteins and their annotated locations for NP_001243763.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' coding region, which results in translation initiation from an in-frame downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 5 encode the same isoform.
      Source sequence(s)
      AK297976, BC009751
      Consensus CDS
      CCDS58514.1
      UniProtKB/Swiss-Prot
      Q96GD4
      Related
      ENSP00000443869.1, ENST00000534871.5
      Conserved Domains (2) summary
      smart00220
      Location:36286
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:29298
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001284526.2NP_001271455.1  aurora kinase B isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame acceptor splice site in the mid-coding region compared to variant 1. The resulting isoform (3) is one amino acid longer than isoform 1.
      Source sequence(s)
      BC009751, BC013300
      Consensus CDS
      CCDS67162.1
      UniProtKB/Swiss-Prot
      Q96GD4
      Related
      ENSP00000313950.6, ENST00000316199.10
      Conserved Domains (2) summary
      smart00220
      Location:78328
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:71340
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001313950.2NP_001300879.1  aurora kinase B isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate acceptor splice site in the 5' non-coding region compared to variant 1. Variants 4 and 1 encode the same isoform (1).
      Source sequence(s)
      BC009751, BP225027, CX781462
      Consensus CDS
      CCDS11134.1
      UniProtKB/Swiss-Prot
      Q96GD4
      Conserved Domains (1) summary
      cl21453
      Location:70339
      PKc_like; Protein Kinases, catalytic domain
    4. NM_001313951.1NP_001300880.1  aurora kinase B isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains a novel exon in the 5' region, which results in translation initiation from an in-frame downstream start codon compared to variant 1. Variants 5 and 2 encode the same isoform (2).
      Source sequence(s)
      BC009751, BE797606, BP225027
      Consensus CDS
      CCDS58514.1
      UniProtKB/Swiss-Prot
      Q96GD4
      Conserved Domains (2) summary
      smart00220
      Location:36286
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:29298
      PKc_like; Protein Kinases, catalytic domain
    5. NM_001313952.2NP_001300881.1  aurora kinase B isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an exon in the 5' coding region and uses two alternate acceptor splice sites in the mid-region compared to variant 1. The encoded isoform (4), resulting from use of an in-frame downstream start codon, has a shorter N-terminus and and an extra amino acid in the mid-region compared to isoform 1.
      Source sequence(s)
      BC009751, BM905813, BP225027
      UniProtKB/Swiss-Prot
      Q96GD4
      Conserved Domains (2) summary
      smart00220
      Location:37287
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:30299
      PKc_like; Protein Kinases, catalytic domain
    6. NM_001313953.3NP_001300882.1  aurora kinase B isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses alternate in-frame donor and acceptor splices sites in the mid-coding region compared to variant 1. The resulting isoform (5) is shorter containing a 16 aa protein segment not found in isoform 1.
      Source sequence(s)
      AC135178, BC009751, BU153790
      Consensus CDS
      CCDS82065.1
      UniProtKB/Swiss-Prot
      Q96GD4
      Related
      ENSP00000462207.1, ENST00000578549.5
      Conserved Domains (2) summary
      smart00220
      Location:102295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:70307
      PKc_like; Protein Kinases, catalytic domain
    7. NM_001313954.2NP_001300883.1  aurora kinase B isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) uses an alternate donor splice site in the mid-region compared to variant 1. It represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render this transcript variant a candidate for nonsense-mediated mRNA decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which would result in an isoform (6) that is shorter, with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AF004022, BC009751, BP225027, BU181480
      UniProtKB/Swiss-Prot
      Q96GD4
      Conserved Domains (2) summary
      smart00220
      Location:27175
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:21187
      PKc_like; Protein Kinases, catalytic domain
    8. NM_001313955.2NP_001300884.1  aurora kinase B isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks two non-consecutive exons in the 5' and mid-region and uses an alternate donor splice site in the mid-region, compared to variant 1. It represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render this transcript variant a candidate for nonsense-mediated mRNA decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which would result in an isoform (7) that is shorter, with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      BC009751, BI199088, BP225027
      UniProtKB/Swiss-Prot
      Q96GD4
      Conserved Domains (2) summary
      smart00220
      Location:10159
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:10171
      PKc_like; Protein Kinases, catalytic domain
    9. NM_004217.4NP_004208.2  aurora kinase B isoform 1

      See identical proteins and their annotated locations for NP_004208.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes the predominant isoform (1). Variants 1 and 4 encode the same isoform.
      Source sequence(s)
      AC135178, BC000442, BC009751
      Consensus CDS
      CCDS11134.1
      UniProtKB/Swiss-Prot
      Q96GD4
      Related
      ENSP00000463999.1, ENST00000585124.6
      Conserved Domains (1) summary
      cl21453
      Location:70339
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. NR_132730.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses an alternate donor splice site in the mid-region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript variant a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC009751, CN286704
    2. NR_132731.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) lacks an internal exon and uses an alternate acceptor splice site in the mid-region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript variant a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AY677083, BC009751

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      8204731..8210767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017025307.2XP_016880796.1  aurora kinase B isoform X1

      UniProtKB/Swiss-Prot
      Q96GD4
      Conserved Domains (2) summary
      smart00220
      Location:36286
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:29298
      PKc_like; Protein Kinases, catalytic domain
    2. XM_017025308.2XP_016880797.1  aurora kinase B isoform X2

    3. XM_011524072.3XP_011522374.1  aurora kinase B isoform X1

      See identical proteins and their annotated locations for XP_011522374.1

      UniProtKB/Swiss-Prot
      Q96GD4
      Conserved Domains (2) summary
      smart00220
      Location:36286
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:29298
      PKc_like; Protein Kinases, catalytic domain
    4. XM_017025310.1XP_016880799.1  aurora kinase B isoform X3

      Conserved Domains (2) summary
      smart00220
      Location:27175
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:21187
      PKc_like; Protein Kinases, catalytic domain
    5. XM_017025309.1XP_016880798.1  aurora kinase B isoform X3

      Conserved Domains (2) summary
      smart00220
      Location:27175
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:21187
      PKc_like; Protein Kinases, catalytic domain
    6. XM_017025311.1XP_016880800.1  aurora kinase B isoform X3

      Conserved Domains (2) summary
      smart00220
      Location:27175
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:21187
      PKc_like; Protein Kinases, catalytic domain
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