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    CD5 CD5 molecule [ Homo sapiens (human) ]

    Gene ID: 921, updated on 29-Mar-2023


    Official Symbol
    CD5provided by HGNC
    Official Full Name
    CD5 moleculeprovided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000110448 MIM:153340; AllianceGenome:HGNC:1685
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T1; LEU1
    This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and a subset of B lymphocytes. The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
    Biased expression in lymph node (RPKM 19.1), appendix (RPKM 11.9) and 10 other tissues See more
    Try the new Gene table
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    Genomic context

    See CD5 in Genome Data Viewer
    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (61093963..61127852)
    RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (61045145..61079346)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60861435..60895324)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369325 Neighboring gene uncharacterized LOC124902677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:60859431-60860393 Neighboring gene Sharpr-MPRA regulatory region 3147/8872 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:60902229-60902744 Neighboring gene VPS37C subunit of ESCRT-I

    Genomic regions, transcripts, and products


    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018


    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?


    EBI GWAS Catalog

    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CD5 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef impairs the generation of a CD3epsilon(+)CD5(+) CD1a(+) T cell differentiation precursor stage that initiates a D-J rearrangement of the TCRbeta locus PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information


    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    enables scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
    enables signaling receptor activity NAS
    Non-traceable Author Statement
    more info
    Process Evidence Code Pubs
    involved_in T cell costimulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    involved_in apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    involved_in cell recognition NAS
    Non-traceable Author Statement
    more info
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info

    General protein information

    Preferred Names
    T-cell surface glycoprotein CD5
    CD5 antigen (p56-62)
    epididymis secretory sperm binding protein
    lymphocyte antigen T1/Leu-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346456.2NP_001333385.1  T-cell surface glycoprotein CD5 isoform 2

      Status: REVIEWED

      Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. This variant contains long terminal repeat (LTR) sequence and uses an alternate LTR promoter. The protein encoded lacks the leader peptide, compared to isoform 1 and represents an intracellular isoform found in a subset of B lymphocytes. (PMID: 15998834)
      Source sequence(s)
      AP000437, BC027901
    2. NM_014207.4NP_055022.2  T-cell surface glycoprotein CD5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_055022.2

      Status: REVIEWED

      Transcript Variant: This variant (1) encodes the longer isoform (1). The protein encoded represents an isoform found on the surface of T lymphocytes, B lymphocytes and thymocytes.
      Source sequence(s)
      AK292698, AP000437, BC027901, DB143341, X04391
      Consensus CDS
      A8K9I3, P06127
      ENSP00000342681.3, ENST00000347785.8
      Conserved Domains (1) summary
      SR; Scavenger receptor Cys-rich

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly


    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0


    1. NC_060935.1 Alternate T2T-CHM13v2.0

      GenBank, FASTA, Sequence Viewer (Graphics)