Format

Send to:

Choose Destination
    • Showing Current items.

    ZNF300 zinc finger protein 300 [ Homo sapiens (human) ]

    Gene ID: 91975, updated on 17-Jun-2019

    Summary

    Official Symbol
    ZNF300provided by HGNC
    Official Full Name
    zinc finger protein 300provided by HGNC
    Primary source
    HGNC:HGNC:13091
    See related
    Ensembl:ENSG00000145908 MIM:612429
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and likely transcriptional regulator. The function of this protein is not yet known. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
    Expression
    Ubiquitous expression in ovary (RPKM 3.4), testis (RPKM 3.0) and 24 other tissues See more
    Orthologs

    Genomic context

    See ZNF300 in Genome Data Viewer
    Location:
    5q33.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (150892958..150904983, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (150273954..150284545, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene dynactin subunit 4 Neighboring gene small integral membrane protein 3 Neighboring gene immunity related GTPase M Neighboring gene zinc finger protein 300 pseudogene 1 Neighboring gene zinc finger protein 35 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp686B24204

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger protein 300
    Names
    kruppel-like zinc finger protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016866.1 RefSeqGene

      Range
      5001..15592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001172831.1NP_001166302.1  zinc finger protein 300 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC010441, AF395541, BM824443, DA497503, DC376791
      Consensus CDS
      CCDS54940.1
      UniProtKB/Swiss-Prot
      Q96RE9
      Related
      ENSP00000397178.2, ENST00000446148.6
      Conserved Domains (6) summary
      smart00349
      Location:2484
      KRAB; krueppel associated box
      COG5048
      Location:258616
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:483503
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:481503
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:2463
      KRAB; KRAB box
      pfam13465
      Location:327352
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001172832.1NP_001166303.1  zinc finger protein 300 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC010441, AF395541, BM824443, DA497503, DB094933
      Consensus CDS
      CCDS54939.1
      UniProtKB/Swiss-Prot
      Q96RE9
      Related
      ENSP00000392593.2, ENST00000418587.6
      Conserved Domains (5) summary
      smart00349
      Location:132
      KRAB; krueppel associated box
      COG5048
      Location:206564
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:431451
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:429451
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:275300
      zf-H2C2_2; Zinc-finger double domain
    3. NM_052860.2NP_443092.1  zinc finger protein 300 isoform 2

      See identical proteins and their annotated locations for NP_443092.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC010441, AF395541, BM824443, DA497503
      Consensus CDS
      CCDS4311.2
      UniProtKB/Swiss-Prot
      Q96RE9
      Related
      ENSP00000274599.5, ENST00000274599.9
      Conserved Domains (3) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:294590
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:467487
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      150892958..150904983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537702.2XP_011536004.1  zinc finger protein 300 isoform X1

      See identical proteins and their annotated locations for XP_011536004.1

      Conserved Domains (6) summary
      smart00349
      Location:1373
      KRAB; krueppel associated box
      COG5048
      Location:299595
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:472492
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:470492
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:1352
      KRAB; KRAB box
      pfam13465
      Location:316341
      zf-H2C2_2; Zinc-finger double domain
    Support Center