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    NXPE3 neurexophilin and PC-esterase domain family member 3 [ Homo sapiens (human) ]

    Gene ID: 91775, updated on 15-Jun-2019

    Summary

    Official Symbol
    NXPE3provided by HGNC
    Official Full Name
    neurexophilin and PC-esterase domain family member 3provided by HGNC
    Primary source
    HGNC:HGNC:28238
    See related
    Ensembl:ENSG00000144815
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM55C; MST115; MSTP115
    Summary
    This gene encodes a member of the neurexophilin family of neuropeptide-like glycoproteins. The encoded protein contains a variable N-terminal domain, a highly conserved neurexophilin and PC-esterase (NXPE) central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein binds alpha neurexins, a group of presynaptic transmembrane receptors that promote adhesion between dendrites and axons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
    Expression
    Ubiquitous expression in brain (RPKM 6.4), lymph node (RPKM 5.0) and 24 other tissues See more
    Orthologs

    Genomic context

    See NXPE3 in Genome Data Viewer
    Location:
    3q12.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (101779177..101828231)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (101498029..101547075)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene PDCL3 pseudogene 4 Neighboring gene centrosomal protein 97 Neighboring gene NFKB inhibitor zeta Neighboring gene long intergenic non-protein coding RNA 2085 Neighboring gene uncharacterized LOC101929411

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ30102, MGC15606

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    NXPE family member 3
    Names
    family with sequence similarity 55, member C

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053180.1 RefSeqGene

      Range
      4993..54047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001134456.2NP_001127928.1  NXPE family member 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001127928.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1-8 encode the same isoform (1).
      Source sequence(s)
      AC020651, AC084198
      Consensus CDS
      CCDS2945.1
      UniProtKB/Swiss-Prot
      Q969Y0
      Related
      ENSP00000417485.1, ENST00000491511.6
      Conserved Domains (1) summary
      pfam06312
      Location:75284
      Neurexophilin; Neurexophilin
    2. NM_001348990.2NP_001335919.1  NXPE family member 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same isoform (1).
      Source sequence(s)
      AC020651, AC084198
      Consensus CDS
      CCDS2945.1
      Conserved Domains (1) summary
      pfam06312
      Location:75284
      Neurexophilin; Neurexophilin
    3. NM_001348991.2NP_001335920.1  NXPE family member 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same isoform (1).
      Source sequence(s)
      AC020651, AC084198
      Consensus CDS
      CCDS2945.1
      Conserved Domains (1) summary
      pfam06312
      Location:75284
      Neurexophilin; Neurexophilin
    4. NM_001348992.2NP_001335921.1  NXPE family member 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same isoform (1).
      Source sequence(s)
      AC020651, AC084198
      Consensus CDS
      CCDS2945.1
      Conserved Domains (1) summary
      pfam06312
      Location:75284
      Neurexophilin; Neurexophilin
    5. NM_001348993.2NP_001335922.1  NXPE family member 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same isoform (1).
      Source sequence(s)
      AC020651, AC084198
      Consensus CDS
      CCDS2945.1
      Conserved Domains (1) summary
      pfam06312
      Location:75284
      Neurexophilin; Neurexophilin
    6. NM_001348994.2NP_001335923.1  NXPE family member 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same isoform (1).
      Source sequence(s)
      AC020651, AC084198
      Consensus CDS
      CCDS2945.1
      Conserved Domains (1) summary
      pfam06312
      Location:75284
      Neurexophilin; Neurexophilin
    7. NM_001348995.2NP_001335924.1  NXPE family member 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same isoform (1).
      Source sequence(s)
      AC020651, AC084198
      Consensus CDS
      CCDS2945.1
      Conserved Domains (1) summary
      pfam06312
      Location:75284
      Neurexophilin; Neurexophilin
    8. NM_001348996.2NP_001335925.1  NXPE family member 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 9-11 encode the same isoform (2).
      Source sequence(s)
      AC020651, AC084198
      Conserved Domains (1) summary
      pfam06312
      Location:75284
      Neurexophilin
    9. NM_001348997.2NP_001335926.1  NXPE family member 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 9-11 encode the same isoform (2).
      Source sequence(s)
      AC020651, AC084198
      Conserved Domains (1) summary
      pfam06312
      Location:75284
      Neurexophilin
    10. NM_001348998.2NP_001335927.1  NXPE family member 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) lacks an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 9-11 encode the same isoform (2).
      Source sequence(s)
      AC020651, AC084198
      Conserved Domains (1) summary
      pfam06312
      Location:75284
      Neurexophilin
    11. NM_145037.4NP_659474.1  NXPE family member 3 isoform 1

      See identical proteins and their annotated locations for NP_659474.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same isoform (1).
      Source sequence(s)
      AC020651, AC084198
      Consensus CDS
      CCDS2945.1
      UniProtKB/Swiss-Prot
      Q969Y0
      Related
      ENSP00000273347.5, ENST00000273347.10
      Conserved Domains (1) summary
      pfam06312
      Location:75284
      Neurexophilin; Neurexophilin

    RNA

    1. NR_145993.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) uses an alternate 5' exon structure and lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC020651, AC084198, BC009431, BQ014992

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      101779177..101828231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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