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    ACY3 aminoacylase 3 [ Homo sapiens (human) ]

    Gene ID: 91703, updated on 8-Jul-2021

    Summary

    Official Symbol
    ACY3provided by HGNC
    Official Full Name
    aminoacylase 3provided by HGNC
    Primary source
    HGNC:HGNC:24104
    See related
    Ensembl:ENSG00000132744 MIM:614413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACY-3; HCBP1
    Expression
    Biased expression in kidney (RPKM 28.0), duodenum (RPKM 26.6) and 8 other tissues See more
    Orthologs
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    Genomic context

    See ACY3 in Genome Data Viewer
    Location:
    11q13.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (67642551..67650829, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67410026..67418201, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene nudix hydrolase 8 Neighboring gene T-box transcription factor 10 Neighboring gene aldehyde dehydrogenase 3 family member B2 Neighboring gene ribosomal protein L37 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    Associated conditions

    Description Tests
    Genetic determinants influencing human serum metabolome among African Americans.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC9740

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aminoacylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables aminoacylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 

    General protein information

    Preferred Names
    N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
    Names
    HCV core-binding protein 1
    acylase III
    aspartoacylase (aminoacylase) 3
    aspartoacylase (aminocyclase) 3
    aspartoacylase-2
    hepatitis C virus core-binding protein 1
    NP_542389.1
    XP_016874038.1
    XP_016874039.1
    XP_016874040.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080658.2NP_542389.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)

      See identical proteins and their annotated locations for NP_542389.1

      Status: VALIDATED

      Source sequence(s)
      AP003385, BC008689
      Consensus CDS
      CCDS8175.1
      UniProtKB/Swiss-Prot
      Q96HD9
      UniProtKB/TrEMBL
      A0A024R5L2
      Related
      ENSP00000255082.3, ENST00000255082.8
      Conserved Domains (1) summary
      cd06909
      Location:12300
      M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      67642551..67650829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018549.1XP_016874038.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X1

    2. XM_017018550.1XP_016874039.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X1

    3. XM_017018551.1XP_016874040.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X2

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