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    CD2 CD2 molecule [ Homo sapiens (human) ]

    Gene ID: 914, updated on 18-Sep-2024

    Summary

    Official Symbol
    CD2provided by HGNC
    Official Full Name
    CD2 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:1639
    See related
    Ensembl:ENSG00000116824 MIM:186990; AllianceGenome:HGNC:1639
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T11; SRBC; LFA-2
    Summary
    The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene. [provided by RefSeq, Jun 2016]
    Expression
    Biased expression in lymph node (RPKM 56.3), appendix (RPKM 28.1) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CD2 in Genome Data Viewer
    Location:
    1p13.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (116754430..116769229)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (116764873..116779672)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (117297052..117311851)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 64 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1574 Neighboring gene CD2 5' regulatory region Neighboring gene NEFH pseudogene 1 Neighboring gene CD2 locus control region Neighboring gene ferritin heavy chain 1 pseudogene 22 Neighboring gene Sharpr-MPRA regulatory region 9503 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:117363109-117363310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1575 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:117403141-117403881 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:117403882-117404621 Neighboring gene Sharpr-MPRA regulatory region 12934 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:117421310-117422509 Neighboring gene uncharacterized LOC105378927

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Molecular interactions of CD2 with LFA-3 and CD28 with B7-1 in conjunction with TCR occupancy prevent T cells from programmed apoptosis mediated by binding of CD4 to HIV-1 gp120, resulting in increased levels of IL-2 and IL-4 secretion from the T cells PubMed
    env Preincubation of T cells with HIV-1 gp120 accelerates the apoptosis observed during CD2-pathway stimulation of the T cells; this process is mediated by Fas/Fas ligand interaction and related to an increased induction of Fas ligand mRNA by gp120 PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 peptide (amino acids 581-597) inhibits lymphoproliferation stimulated via the T-cell-activation molecules CD3, CD2, and CD28, as well as via direct stimulation mediated by phorbol ester combined with ionomycin PubMed
    capsid gag Interferon-gamma can counteract the inhibitory effect of HIV-1 Capsid based peptides on antibody response to SRC PubMed
    gag Peptides corresponding to amino acids 218-238 of HIV-1 Capsid inhibited anti-CD3-induced lymphoproliferation but did not directly affect anti-CD2 activation PubMed
    gag Synthetic peptides corresponding to amino acids 218-238 of HIV-1 Capsid have been shown to inhibit in a dose dependent manner the induction of a specific antibody response to the sheep red cell (SRC) antigen PubMed
    nucleocapsid gag HIV-1 NC downregulates CD2 in HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ46032

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in T cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in heterotypic cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in membrane raft polarization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in natural killer cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in natural killer cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in natural killer cell activation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in natural killer cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-8 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of myeloid dendritic cell activation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of type II interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of T cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    T-cell surface antigen CD2
    Names
    CD2 antigen (p50), sheep red blood cell receptor
    LFA-3 receptor
    T-cell surface antigen T11/Leu-5
    erythrocyte receptor
    lymphocyte-function antigen-2
    rosette receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050908.1 RefSeqGene

      Range
      5001..19800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001328609.2NP_001315538.1  T-cell surface antigen CD2 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK313614, AL135798, BC033583, CD691699, CR996443
      UniProtKB/Swiss-Prot
      P06729
      UniProtKB/TrEMBL
      Q53F96
    2. NM_001767.5NP_001758.2  T-cell surface antigen CD2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001758.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK313614, BC033583, CD691699
      Consensus CDS
      CCDS889.1
      UniProtKB/Swiss-Prot
      P06729, Q96TE5
      UniProtKB/TrEMBL
      Q53F96
      Related
      ENSP00000358490.3, ENST00000369478.4
      Conserved Domains (3) summary
      cd05741
      Location:38122
      Ig_CEACAM_D1_like; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins
      pfam05790
      Location:135205
      C2-set; Immunoglobulin C2-set domain
      cl23807
      Location:247342
      WWbp; WW-domain ligand protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      116754430..116769229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      116764873..116779672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)