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    SLC16A6 solute carrier family 16 member 6 [ Homo sapiens (human) ]

    Gene ID: 9120, updated on 2-Oct-2018

    Summary

    Official Symbol
    SLC16A6provided by HGNC
    Official Full Name
    solute carrier family 16 member 6provided by HGNC
    Primary source
    HGNC:HGNC:10927
    See related
    Ensembl:ENSG00000108932 MIM:603880; Vega:OTTHUMG00000179812
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCT6; MCT7
    Expression
    Broad expression in esophagus (RPKM 4.8), appendix (RPKM 3.2) and 18 other tissues See more
    Orthologs

    Genomic context

    See SLC16A6 in Genome Data Viewer
    Location:
    17q24.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (68267026..68291439, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (66263167..66287405, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 27 pseudogene 2 Neighboring gene archaelysin family metallopeptidase 2 Neighboring gene arylsulfatase G Neighboring gene protein kinase cAMP-dependent type I regulatory subunit alpha Neighboring gene microRNA 635 Neighboring gene WD repeat domain, phosphoinositide interacting 1 Neighboring gene uncharacterized LOC105371873 Neighboring gene FAM20A, golgi associated secretory pathway pseudokinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of solute carrier family 16, member 6 (SLC16A6) in Vif-expression T cells PubMed
    capsid gag Depletion of the SLC16A6 expression upregulates HIV-1 CA A92E mutant infectivity in CsA-untreated HeLa cells and downregulates its infectivity in CsA-treated HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    monocarboxylic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    monocarboxylate transporter 7
    Names
    breast cancer protein BCY5
    monocarboxylate transporter 6
    solute carrier family 16, member 6 (monocarboxylic acid transporter 7)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001174166.1NP_001167637.1  monocarboxylate transporter 7

      See identical proteins and their annotated locations for NP_001167637.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AC005332, BC064832, U79745
      Consensus CDS
      CCDS11675.1
      UniProtKB/Swiss-Prot
      O15403
      UniProtKB/TrEMBL
      A0A024R8J3
      Related
      ENSP00000319991.4, OTTHUMP00000262481, ENST00000327268.8, OTTHUMT00000448323
      Conserved Domains (1) summary
      cl26868
      Location:19508
      2A0111; oxalate/formate antiporter family transporter
    2. NM_004694.4NP_004685.2  monocarboxylate transporter 7

      See identical proteins and their annotated locations for NP_004685.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AC005332, BC064832
      Consensus CDS
      CCDS11675.1
      UniProtKB/Swiss-Prot
      O15403
      UniProtKB/TrEMBL
      A0A024R8J3
      Related
      ENSP00000462985.1, OTTHUMP00000262482, ENST00000580666.5, OTTHUMT00000448324
      Conserved Domains (1) summary
      cl26868
      Location:19508
      2A0111; oxalate/formate antiporter family transporter

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

      Range
      68267026..68291439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451021.1XP_024306789.1  monocarboxylate transporter 7 isoform X1

      Conserved Domains (1) summary
      cl26868
      Location:19508
      2A0111; oxalate/formate antiporter family transporter
    2. XM_011525461.3XP_011523763.1  monocarboxylate transporter 7 isoform X1

      See identical proteins and their annotated locations for XP_011523763.1

      UniProtKB/Swiss-Prot
      O15403
      UniProtKB/TrEMBL
      A0A024R8J3
      Related
      ENSP00000480820.1, ENST00000620436.4
      Conserved Domains (1) summary
      cl26868
      Location:19508
      2A0111; oxalate/formate antiporter family transporter
    3. XM_017025291.2XP_016880780.1  monocarboxylate transporter 7 isoform X1

      UniProtKB/Swiss-Prot
      O15403
      UniProtKB/TrEMBL
      A0A024R8J3
      Conserved Domains (1) summary
      cl26868
      Location:19508
      2A0111; oxalate/formate antiporter family transporter
    4. XM_017025292.2XP_016880781.1  monocarboxylate transporter 7 isoform X1

      UniProtKB/Swiss-Prot
      O15403
      UniProtKB/TrEMBL
      A0A024R8J3
      Conserved Domains (1) summary
      cl26868
      Location:19508
      2A0111; oxalate/formate antiporter family transporter
    5. XM_005257789.4XP_005257846.2  monocarboxylate transporter 7 isoform X2

      Conserved Domains (2) summary
      cd06174
      Location:33476
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:23512
      2A0113; monocarboxylate transporter 1
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