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    TRIM41 tripartite motif containing 41 [ Homo sapiens (human) ]

    Gene ID: 90933, updated on 25-Dec-2023

    Summary

    Official Symbol
    TRIM41provided by HGNC
    Official Full Name
    tripartite motif containing 41provided by HGNC
    Primary source
    HGNC:HGNC:19013
    See related
    Ensembl:ENSG00000146063 MIM:610530; AllianceGenome:HGNC:19013
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RINCK
    Summary
    This gene encodes a member of the tripartite motif (TRIM) family. The TRIM family is characterized by a signature motif composed of a RING finger, one or more B-box domains, and a coiled-coil region. This encoded protein may play a role in protein kinase C signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
    Expression
    Ubiquitous expression in testis (RPKM 14.3), brain (RPKM 9.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TRIM41 in Genome Data Viewer
    Location:
    5q35.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (181223281..181235808)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (181783233..181795759)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180650281..180662808)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16793 Neighboring gene tRNA-Val (anticodon CAC) 1-5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23787 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16794 Neighboring gene microRNA 4638 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180651177-180652174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23788 Neighboring gene receptor for activated C kinase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23789 Neighboring gene small nucleolar RNA, C/D box 96A Neighboring gene small nucleolar RNA, C/D box 95

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC1127, MGC31991

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM41
    Names
    RING finger-interacting protein with C kinase
    RING-finger protein that interacts with C kinase
    RING-type E3 ubiquitin transferase TRIM41
    NP_291027.3
    NP_963921.1
    XP_006714992.1
    XP_006714993.1
    XP_006714994.1
    XP_006714995.1
    XP_047273824.1
    XP_054209740.1
    XP_054209741.1
    XP_054209742.1
    XP_054209743.1
    XP_054209744.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030346.1 RefSeqGene

      Range
      5019..17546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_033549.5NP_291027.3  E3 ubiquitin-protein ligase TRIM41 isoform 1

      See identical proteins and their annotated locations for NP_291027.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also referred to as alpha) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC018765, BC090953, DA341383
      Consensus CDS
      CCDS4466.1
      UniProtKB/Swiss-Prot
      B3KNJ6, D3DWR9, Q5BKT0, Q7L484, Q8WV44, Q96Q10, Q9BSL8
      Related
      ENSP00000320869.5, ENST00000315073.10
      Conserved Domains (5) summary
      cd00021
      Location:226263
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd13741
      Location:432630
      SPRY_PRY_TRIM41; PRY/SPRY domain in tripartite motif-binding protein 41 (TRIM41)
      pfam01442
      Location:263374
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cl00459
      Location:286381
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl17238
      Location:2048
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. NM_201627.3NP_963921.1  E3 ubiquitin-protein ligase TRIM41 isoform 2

      See identical proteins and their annotated locations for NP_963921.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also referred to as beta) includes several alternate exons and an alternate splice pattern in the 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2, which has a distinct C-terminus, compared to isoform.
      Source sequence(s)
      AK027601, BC018765, BC090953, DA341383
      Consensus CDS
      CCDS4465.1
      UniProtKB/Swiss-Prot
      Q8WV44
      Related
      ENSP00000336749.6, ENST00000351937.9
      Conserved Domains (5) summary
      cd00021
      Location:226263
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam01442
      Location:263374
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cl00459
      Location:286381
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl02614
      Location:432489
      SPRY; SPRY domain
      cl17238
      Location:2048
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RNA

    1. NR_045218.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) includes several alternate exons and an alternate splice pattern, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK027601, BC004956, BC018765, DA341383

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      181223281..181235808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006714929.3XP_006714992.1  E3 ubiquitin-protein ligase TRIM41 isoform X1

      Conserved Domains (5) summary
      cd00021
      Location:226263
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam01442
      Location:263374
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cl00459
      Location:286381
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl02614
      Location:432498
      SPRY; SPRY domain
      cl17238
      Location:2048
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. XM_006714932.4XP_006714995.1  E3 ubiquitin-protein ligase TRIM41 isoform X4

      Conserved Domains (5) summary
      cd00021
      Location:226263
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam01442
      Location:263374
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cl00459
      Location:286381
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl02614
      Location:432498
      SPRY; SPRY domain
      cl17238
      Location:2048
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    3. XM_006714930.3XP_006714993.1  E3 ubiquitin-protein ligase TRIM41 isoform X2

      Conserved Domains (5) summary
      cd00021
      Location:226263
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam01442
      Location:263374
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cl00459
      Location:286381
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl02614
      Location:432489
      SPRY; SPRY domain
      cl17238
      Location:2048
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    4. XM_047417868.1XP_047273824.1  E3 ubiquitin-protein ligase TRIM41 isoform X5

    5. XM_006714931.4XP_006714994.1  E3 ubiquitin-protein ligase TRIM41 isoform X3

      Conserved Domains (5) summary
      cd00021
      Location:226263
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam01442
      Location:263374
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cl00459
      Location:286381
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl02614
      Location:432491
      SPRY; SPRY domain
      cl17238
      Location:2048
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      181783233..181795759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353768.1XP_054209743.1  E3 ubiquitin-protein ligase TRIM41 isoform X4

    2. XM_054353767.1XP_054209742.1  E3 ubiquitin-protein ligase TRIM41 isoform X3

    3. XM_054353765.1XP_054209740.1  E3 ubiquitin-protein ligase TRIM41 isoform X1

    4. XM_054353766.1XP_054209741.1  E3 ubiquitin-protein ligase TRIM41 isoform X2

    5. XM_054353769.1XP_054209744.1  E3 ubiquitin-protein ligase TRIM41 isoform X5