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    SYT7 synaptotagmin 7 [ Homo sapiens (human) ]

    Gene ID: 9066, updated on 6-Sep-2021

    Summary

    Official Symbol
    SYT7provided by HGNC
    Official Full Name
    synaptotagmin 7provided by HGNC
    Primary source
    HGNC:HGNC:11514
    See related
    Ensembl:ENSG00000011347 MIM:604146
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IPCA7; IPCA-7; SYTVII; PCANAP7; SYT-VII
    Summary
    This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
    Expression
    Biased expression in brain (RPKM 15.4), prostate (RPKM 13.8) and 12 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SYT7 in Genome Data Viewer
    Location:
    11q12.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (61513714..61588404, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (61281186..61348548, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene microRNA 4488 Neighboring gene leucine rich repeat containing 10B Neighboring gene uncharacterized LOC105369331 Neighboring gene uncharacterized LOC101927495 Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC150517

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium-dependent phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium-dependent phospholipid binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables calmodulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in calcium ion regulated lysosome exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in calcium ion-regulated exocytosis of neurotransmitter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in calcium-ion regulated exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phagosome-lysosome fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in plasma membrane repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of calcium ion-dependent exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of bone remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of dopamine secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of glucagon secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of insulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in short-term synaptic potentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in synaptic vesicle recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vesicle-mediated cholesterol transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dense core granule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early phagosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in hippocampal mossy fiber to CA3 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in synaptic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    synaptotagmin-7
    Names
    prostate cancer-associated protein 7
    synaptotagmin VII

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252065.2NP_001238994.1  synaptotagmin-7 isoform 1

      See identical proteins and their annotated locations for NP_001238994.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AP002754, AP003108, BC042495, BC125171, BE644642, BM675410, BQ447018
      Consensus CDS
      CCDS58139.1
      UniProtKB/Swiss-Prot
      O43581
      Related
      ENSP00000444201.1, ENST00000540677.5
      Conserved Domains (2) summary
      cd08386
      Location:210334
      C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
      cd08405
      Location:342477
      C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    2. NM_001300773.2NP_001287702.1  synaptotagmin-7 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate in-frame exon in place of another alternate in-frame exon compared to variant 1. The resulting isoform (3) has an alternate 44 aa internal segment in place of an alternate 75 aa internal segment compared to isoform 1.
      Source sequence(s)
      AP002754, AP003108, BC042495, BC125170, BE644642, BQ447018, CA868518
      Consensus CDS
      CCDS73298.1
      UniProtKB/Swiss-Prot
      O43581
      Related
      ENSP00000444568.1, ENST00000542836.5
      Conserved Domains (2) summary
      cd08386
      Location:179303
      C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
      cd08405
      Location:311446
      C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    3. NM_001365809.2NP_001352738.1  synaptotagmin-7 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AP002754, AP003108, AP003559
      Related
      ENSP00000439694.1, ENST00000539008.6
      Conserved Domains (3) summary
      cd08386
      Location:418542
      C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
      cd08405
      Location:550685
      C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
      PHA03307
      Location:143310
      PHA03307; transcriptional regulator ICP4; Provisional
    4. NM_001370210.1NP_001357139.1  synaptotagmin-7 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AP003108, AP003559
      Conserved Domains (2) summary
      cd08386
      Location:231355
      C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
      cl14603
      Location:363466
      C2; C2 domain
    5. NM_001370211.1NP_001357140.1  synaptotagmin-7 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AP002754, AP003108, AP003559
      Conserved Domains (2) summary
      cd08386
      Location:135259
      C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
      cl14603
      Location:267370
      C2; C2 domain
    6. NM_004200.4NP_004191.2  synaptotagmin-7 isoform 2

      See identical proteins and their annotated locations for NP_004191.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AP002754, AP003108, BC042495, BC125170, BE644642, BM675410, BQ447018
      Consensus CDS
      CCDS31577.1
      UniProtKB/Swiss-Prot
      O43581
      Related
      ENSP00000263846.4, ENST00000263846.8
      Conserved Domains (2) summary
      cd08386
      Location:135259
      C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
      cd08405
      Location:267402
      C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      61513714..61588404 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545335.2XP_011543637.1  synaptotagmin-7 isoform X1

      Conserved Domains (2) summary
      cd08386
      Location:424548
      C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
      cd08405
      Location:556691
      C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    2. XM_011545337.2XP_011543639.1  synaptotagmin-7 isoform X4

      Conserved Domains (2) summary
      cd08386
      Location:380504
      C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
      cd08405
      Location:512647
      C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    3. XM_011545336.2XP_011543638.1  synaptotagmin-7 isoform X3

      Conserved Domains (2) summary
      cd08386
      Location:383507
      C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
      cd08405
      Location:515650
      C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    4. XM_011545338.2XP_011543640.1  synaptotagmin-7 isoform X6

      Conserved Domains (2) summary
      cd08386
      Location:349473
      C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
      cd08405
      Location:481616
      C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    5. XM_011545339.2XP_011543641.1  synaptotagmin-7 isoform X8

      Related
      ENSP00000437720.1, ENST00000535826.5
      Conserved Domains (2) summary
      cd08386
      Location:260384
      C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
      cd08405
      Location:392527
      C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    6. XM_011545340.2XP_011543642.1  synaptotagmin-7 isoform X9

      Conserved Domains (2) summary
      cd08386
      Location:216340
      C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
      cd08405
      Location:348483
      C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    7. XM_011545341.2XP_011543643.1  synaptotagmin-7 isoform X10

      Conserved Domains (2) summary
      cd08386
      Location:185309
      C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
      cd08405
      Location:317452
      C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    8. XM_011545343.2XP_011543645.1  synaptotagmin-7 isoform X13

      Conserved Domains (2) summary
      cd08386
      Location:141265
      C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
      cd08405
      Location:273408
      C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    9. XM_005274384.2XP_005274441.1  synaptotagmin-7 isoform X5

      Conserved Domains (3) summary
      cd08386
      Location:374498
      C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
      cd08405
      Location:506641
      C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
      PHA03307
      Location:99266
      PHA03307; transcriptional regulator ICP4; Provisional
    10. XM_005274385.4XP_005274442.1  synaptotagmin-7 isoform X7

      UniProtKB/Swiss-Prot
      O43581
      Related
      ENSP00000444019.1, ENST00000542670.5
      Conserved Domains (2) summary
      cd08386
      Location:343467
      C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
      cd08405
      Location:475610
      C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    11. XM_005274387.4XP_005274444.1  synaptotagmin-7 isoform X11

      Conserved Domains (2) summary
      cd08386
      Location:181305
      C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
      cd08405
      Location:313448
      C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    12. XM_005274390.5XP_005274447.1  synaptotagmin-7 isoform X15

      Conserved Domains (2) summary
      cd08386
      Location:1103
      C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
      cd08405
      Location:111246
      C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    13. XM_006718736.4XP_006718799.1  synaptotagmin-7 isoform X14

      Conserved Domains (2) summary
      cd08386
      Location:25149
      C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
      cd08405
      Location:157292
      C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    14. XM_011545342.2XP_011543644.1  synaptotagmin-7 isoform X12

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