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    GADD45GIP1 GADD45G interacting protein 1 [ Homo sapiens (human) ]

    Gene ID: 90480, updated on 9-Aug-2021


    Official Symbol
    GADD45GIP1provided by HGNC
    Official Full Name
    GADD45G interacting protein 1provided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000179271 MIM:605162
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRG6; CRIF1; PLINP; CKBBP2; Plinp1; MRP-L59; PLINP-1; CKbetaBP2
    This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]
    Ubiquitous expression in kidney (RPKM 22.3), fat (RPKM 19.9) and 25 other tissues See more
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    Genomic context

    See GADD45GIP1 in Genome Data Viewer
    Exon count:
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (12953119..12957223, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (13063933..13068037, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-FlowFISH-validated RAD23A regulatory element Neighboring gene microRNA 6515 Neighboring gene calreticulin Neighboring gene RAD23 homolog A, nucleotide excision repair protein Neighboring gene DAN domain BMP antagonist family member 5 Neighboring gene nuclear factor I X Neighboring gene uncharacterized LOC107985286

    Genomic regions, transcripts, and products


    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018


    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?


    Associated conditions

    Description Tests
    Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
    GeneReviews: Not available

    Pathways from PubChem


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information



    Clone Names

    • MGC4667, MGC4758

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    Component Evidence Code Pubs
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info

    General protein information

    Preferred Names
    growth arrest and DNA damage-inducible proteins-interacting protein 1
    39S ribosomal protein L59, mitochondrial
    CKII beta binding protein 2
    CKII beta-associating protein
    CR6 interacting factor 1
    growth arrest and DNA-damage-inducible, gamma interacting protein 1
    growth arrest- and DNA damage-inducible GADD45G-interacting protein
    mitochondrial large ribosomal subunit protein CRIF1
    mitochondrial large ribosomal subunit protein mL64
    p53-responsive gene 6 protein
    papillomavirus L2 interacting nuclear protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_052850.4NP_443082.2  growth arrest and DNA damage-inducible proteins-interacting protein 1

      See identical proteins and their annotated locations for NP_443082.2

      Status: REVIEWED

      Source sequence(s)
      AC092069, AF479749, AI309741
      Consensus CDS
      ENSP00000323065.1, ENST00000316939.3
      Conserved Domains (1) summary
      CR6_interact; Growth arrest and DNA-damage-inducible proteins-interacting protein 1

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly


    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      12953119..12957223 complement
      GenBank, FASTA, Sequence Viewer (Graphics)
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