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    SH2D2A SH2 domain containing 2A [ Homo sapiens (human) ]

    Gene ID: 9047, updated on 17-Jun-2019

    Summary

    Official Symbol
    SH2D2Aprovided by HGNC
    Official Full Name
    SH2 domain containing 2Aprovided by HGNC
    Primary source
    HGNC:HGNC:10821
    See related
    Ensembl:ENSG00000027869 MIM:604514
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCAP; TSAD; VRAP; F2771
    Summary
    This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
    Expression
    Broad expression in appendix (RPKM 5.2), lymph node (RPKM 3.5) and 17 other tissues See more
    Orthologs

    Genomic context

    See SH2D2A in Genome Data Viewer
    Location:
    1q23.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (156806238..156816853, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156776035..156786640, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene heparin binding growth factor Neighboring gene proline rich mitotic checkpoint control factor Neighboring gene neurotrophic receptor tyrosine kinase 1 Neighboring gene insulin receptor related receptor Neighboring gene platelet endothelial aggregation receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
    • ErbB1 downstream signaling, organism-specific biosystem (from Pathway Interaction Database)
      ErbB1 downstream signaling, organism-specific biosystem
      ErbB1 downstream signaling
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by VEGF, organism-specific biosystem (from REACTOME)
      Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
    • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
      Signaling events mediated by VEGFR1 and VEGFR2
    • VEGF signaling pathway, organism-specific biosystem (from KEGG)
      VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • VEGF signaling pathway, conserved biosystem (from KEGG)
      VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
      VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    SH3/SH2 adaptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    SH2 domain-containing protein 2A
    Names
    SH2 domain protein 2A
    T cell specific adapter protein TSAd
    T lymphocyte specific adaptor protein
    VEGF receptor-associated protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016849.1 RefSeqGene

      Range
      5001..15606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001161441.1NP_001154913.1  SH2 domain-containing protein 2A isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL158169, AY763099, BQ012931, DB128222
      Consensus CDS
      CCDS53381.1
      UniProtKB/TrEMBL
      Q5UBZ2
      Related
      ENSP00000376123.2, ENST00000392306.2
      Conserved Domains (1) summary
      cl15255
      Location:87198
      SH2; Src homology 2 (SH2) domain
    2. NM_001161442.2NP_001154914.1  SH2 domain-containing protein 2A isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, has multiple differences in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AF051325, AL158169, DB128222
      Consensus CDS
      CCDS53380.1
      UniProtKB/Swiss-Prot
      Q9NP31
      Related
      ENSP00000357181.3, ENST00000368198.7
      Conserved Domains (1) summary
      cd10416
      Location:69170
      SH2_SH2D2A; Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)
    3. NM_001161443.2NP_001154915.1  SH2 domain-containing protein 2A isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, has multiple differences in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AL158169, AY763098, BQ012931
      UniProtKB/TrEMBL
      Q5UBZ3
      Conserved Domains (1) summary
      cd10416
      Location:59160
      SH2_SH2D2A; Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)
    4. NM_001161444.2NP_001154916.1  SH2 domain-containing protein 2A isoform 2

      See identical proteins and their annotated locations for NP_001154916.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 3' UTR, and coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 and 5 encode the same isoform (2).
      Source sequence(s)
      AK222737, DB128222
      Consensus CDS
      CCDS1159.1
      UniProtKB/Swiss-Prot
      Q9NP31
      Conserved Domains (1) summary
      cd10416
      Location:87188
      SH2_SH2D2A; Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)
    5. NM_003975.4NP_003966.2  SH2 domain-containing protein 2A isoform 2

      See identical proteins and their annotated locations for NP_003966.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 and 5 encode the same isoform (2).
      Source sequence(s)
      AL158169, BC012107, DB128222
      Consensus CDS
      CCDS1159.1
      UniProtKB/Swiss-Prot
      Q9NP31
      Related
      ENSP00000357182.3, ENST00000368199.7
      Conserved Domains (1) summary
      cd10416
      Location:87188
      SH2_SH2D2A; Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      156806238..156816853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002767.1XP_016858256.1  SH2 domain-containing protein 2A isoform X7

    2. XM_017002763.1XP_016858252.1  SH2 domain-containing protein 2A isoform X2

    3. XM_017002766.1XP_016858255.1  SH2 domain-containing protein 2A isoform X6

    4. XM_006711615.2XP_006711678.1  SH2 domain-containing protein 2A isoform X3

      Conserved Domains (1) summary
      cd10416
      Location:93194
      SH2_SH2D2A; Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)
    5. XM_017002762.2XP_016858251.1  SH2 domain-containing protein 2A isoform X1

    6. XM_017002765.1XP_016858254.1  SH2 domain-containing protein 2A isoform X5

    7. XM_017002764.2XP_016858253.1  SH2 domain-containing protein 2A isoform X4

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