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    KALRN kalirin RhoGEF kinase [ Homo sapiens (human) ]

    Gene ID: 8997, updated on 18-Jun-2019

    Summary

    Official Symbol
    KALRNprovided by HGNC
    Official Full Name
    kalirin RhoGEF kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:4814
    See related
    Ensembl:ENSG00000160145 MIM:604605
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DUO; CHD5; DUET; TRAD; CHDS5; HAPIP; ARHGEF24
    Summary
    Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016]
    Expression
    Broad expression in brain (RPKM 3.5), small intestine (RPKM 1.5) and 20 other tissues See more
    Orthologs

    Genomic context

    See KALRN in Genome Data Viewer
    Location:
    3q21.1-q21.2
    Exon count:
    66
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (124033341..124726325)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (123813558..124440036)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 14 Neighboring gene rhophilin associated tail protein 1 Neighboring gene uncharacterized LOC105374077 Neighboring gene microRNA 5002 Neighboring gene ribosomal protein L7 pseudogene 15 Neighboring gene uncharacterized LOC107986123 Neighboring gene microRNA 6083 Neighboring gene RNA, U6 small nuclear 143, pseudogene Neighboring gene uncharacterized LOC105374076 Neighboring gene mediator of cell motility 1 pseudogene Neighboring gene ribosomal protein S26 pseudogene 22 Neighboring gene microRNA 544b Neighboring gene uridine monophosphate synthetase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Coronary heart disease 5
    MedGen: C1837173 OMIM: 608901 GeneReviews: Not available
    not available

    NHGRI GWAS Catalog

    Description
    A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
    NHGRI GWA Catalog
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    NHGRI GWA Catalog
    Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.
    NHGRI GWA Catalog
    New gene functions in megakaryopoiesis and platelet formation.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of kalirin, RhoGEF kinase (KALRN) by siRNA inhibits HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Arf6 downstream pathway, organism-specific biosystem (from Pathway Interaction Database)
      Arf6 downstream pathway, organism-specific biosystem
      Arf6 downstream pathway
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
      Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemp75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNG...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
      EPH-Ephrin signaling, organism-specific biosystemDuring the development process cell migration and adhesion are the main forces involved in morphing the cells into critical anatomical structures. The ability of a cell to migrate to its correct dest...
    • EPHB forward signaling, organism-specific biosystem (from Pathway Interaction Database)
      EPHB forward signaling, organism-specific biosystem
      EPHB forward signaling
    • EPHB-mediated forward signaling, organism-specific biosystem (from REACTOME)
      EPHB-mediated forward signaling, organism-specific biosystemMultiple EPHB receptors contribute directly to dendritic spine development and morphogenesis. These are more broadly involved in post-synaptic development through activation of focal adhesion kinase ...
    • G alpha (12/13) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (12/13) signalling events, organism-specific biosystemThe G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay te...
    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
      Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
    • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
      MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
    • MAPK6/MAPK4 signaling, organism-specific biosystem (from REACTOME)
      MAPK6/MAPK4 signaling, organism-specific biosystemMAPK6 and MAPK4 (also known as ERK3 and ERK4) are vertebrate-specific atypical MAP kinases. Atypical MAPK are less well characterized than their conventional counterparts, and are generally classifi...
    • NRAGE signals death through JNK, organism-specific biosystem (from REACTOME)
      NRAGE signals death through JNK, organism-specific biosystemOnce bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pr...
    • Regulation of RAC1 activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of RAC1 activity, organism-specific biosystem
      Regulation of RAC1 activity
    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
      p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ12332, FLJ16443, FLJ18196, FLJ18623

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    Rho guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    guanyl-nucleotide exchange factor activity EXP
    Inferred from Experiment
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    adult locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    habituation IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lactation IEA
    Inferred from Electronic Annotation
    more info
     
    maternal behavior IEA
    Inferred from Electronic Annotation
    more info
     
    maternal process involved in parturition IEA
    Inferred from Electronic Annotation
    more info
     
    memory IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of growth hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuromuscular junction development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process TAS
    Traceable Author Statement
    more info
     
    positive regulation of dendritic spine morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    social behavior IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    kalirin
    Names
    huntingtin-associated protein interacting protein (duo)
    serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
    NP_001019831.2
    NP_001309917.1
    NP_001309918.1
    NP_001309919.1
    NP_001309920.1
    NP_001309921.1
    NP_001309922.1
    NP_001309923.1
    NP_001309924.1
    NP_001309925.1
    NP_001309926.1
    NP_001309927.1
    NP_001309928.1
    NP_001309929.1
    NP_001309930.1
    NP_003938.1
    NP_008995.2
    XP_006713873.1
    XP_006713874.1
    XP_006713875.1
    XP_006713876.1
    XP_006713877.1
    XP_006713878.1
    XP_011511581.1
    XP_011511582.1
    XP_011511583.1
    XP_011511585.1
    XP_011511587.1
    XP_016862918.1
    XP_016862919.1
    XP_016862920.1
    XP_016862921.1
    XP_016862922.1
    XP_016862923.1
    XP_016862924.1
    XP_024309579.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012742.2 RefSeqGene

      Range
      4971..636615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001024660.4NP_001019831.2  kalirin isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). There are no publicly available transcripts representing the full-length splicing pattern of this variant; it is inferred from data in PMID:11891045 and from the rat homolog, NM_032062.1.
      Source sequence(s)
      AB011422, AC022336, AK125979, AK131379, AK314126, BM930007, BQ345377, DA756158, H11479, R45191, U94190
      UniProtKB/Swiss-Prot
      O60229
      UniProtKB/TrEMBL
      J3QSW6
      Related
      ENSP00000353109.3, ENST00000360013.7
      Conserved Domains (16) summary
      cd00096
      Location:24882562
      Ig; Immunoglobulin domain
      cd11852
      Location:16491708
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23252383
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:26842938
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:39177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25692660
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12841454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8911129
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:24712565
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:14611583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21072241
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26902937
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00169
      Location:14941579
      PH; PH domain
      pfam00621
      Location:19332103
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17061932
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:10991238
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    2. NM_001322988.1NP_001309917.1  kalirin isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC069233, AC080008, AC112129, AC117401, AL137629
      UniProtKB/Swiss-Prot
      O60229
    3. NM_001322989.2NP_001309918.1  kalirin isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC069233, AC112129, AI024603, AK314126, U94190
      Consensus CDS
      CCDS82829.1
      UniProtKB/Swiss-Prot
      O60229
      UniProtKB/TrEMBL
      C9IZQ6
      Related
      ENSP00000418611.1, ENST00000460856.5
      Conserved Domains (6) summary
      smart00150
      Location:11261226
      SPEC; Spectrin repeats
      smart00516
      Location:39177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12751445
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8911120
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14521574
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      pfam00169
      Location:14851570
      PH; PH domain
    4. NM_001322990.2NP_001309919.1  kalirin isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC069233, AC080008, AC112129, AC117401, AI024603
    5. NM_001322991.2NP_001309920.1  kalirin isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC069233, AC080008, AC112129, AC117401, AI024603
    6. NM_001322992.2NP_001309921.1  kalirin isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC069233, AC080008, AC112129, AC117401, AI024603
    7. NM_001322993.2NP_001309922.1  kalirin isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC022336, AC080008, H11479
    8. NM_001322994.1NP_001309923.1  kalirin isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC080008, AL137629
      UniProtKB/Swiss-Prot
      O60229
    9. NM_001322995.2NP_001309924.1  kalirin isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC080008, AL137629
      UniProtKB/Swiss-Prot
      O60229
    10. NM_001322996.1NP_001309925.1  kalirin isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC080008, AL137629
      UniProtKB/Swiss-Prot
      O60229
      Conserved Domains (5) summary
      cd11853
      Location:627685
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd13241
      Location:410544
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:443529
      PH; PH domain
      pfam00621
      Location:236406
      RhoGEF; RhoGEF domain
      pfam16609
      Location:25235
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    11. NM_001322997.1NP_001309926.1  kalirin isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC080008, AL137629
      UniProtKB/Swiss-Prot
      O60229
    12. NM_001322998.2NP_001309927.1  kalirin isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC080008, AL137629
      UniProtKB/Swiss-Prot
      O60229
    13. NM_001322999.2NP_001309928.1  kalirin isoform 15

      Status: REVIEWED

      Description
      Transcript Variant: Variants 16 and 17 encode isoforms that are the same length, but have distinct protein sequences.
      Source sequence(s)
      AC080008, AL137629
      UniProtKB/Swiss-Prot
      O60229
    14. NM_001323000.1NP_001309929.1  kalirin isoform 16

      Status: REVIEWED

      Description
      Transcript Variant: Variants 16 and 17 encode isoforms that are the same length, but have distinct protein sequences.
      Source sequence(s)
      AC080008, AL137629
      UniProtKB/Swiss-Prot
      O60229
    15. NM_001323001.1NP_001309930.1  kalirin isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC080008, AL137629
      UniProtKB/Swiss-Prot
      O60229
    16. NM_003947.6NP_003938.1  kalirin isoform 2

      See identical proteins and their annotated locations for NP_003938.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and lacks many exons in the 3' coding region, compared to variant 1. The encoded protein (isoform 2), also known as Trad and Duet, is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI024603, AK131379, AK314126, BQ345377, U94190
      Consensus CDS
      CCDS3027.1
      UniProtKB/Swiss-Prot
      O60229
      Related
      ENSP00000240874.3, ENST00000240874.7
      Conserved Domains (6) summary
      smart00150
      Location:11351235
      SPEC; Spectrin repeats
      smart00516
      Location:39177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12841454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:537718
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14611583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      pfam00169
      Location:14941579
      PH; PH domain
    17. NM_007064.5NP_008995.2  kalirin isoform 3

      See identical proteins and their annotated locations for NP_008995.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks many exons in the 5' coding region, compared to variant 1. The encoded protein (isoform 3), also known as Duo, is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AB011422, AC022336, AC080008, AK125979, BM930007, DA756158, DB450617, H11479, R45191
      Consensus CDS
      CCDS3028.1
      UniProtKB/Swiss-Prot
      O60229
      Related
      ENSP00000291478.4, ENST00000291478.9
      Conserved Domains (9) summary
      cd00096
      Location:791865
      Ig; Immunoglobulin domain
      cd11853
      Location:628686
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:9871241
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00063
      Location:872963
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:774868
      I-set; Immunoglobulin I-set domain
      cd13241
      Location:410544
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:9931240
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:236406
      RhoGEF; RhoGEF domain
      pfam16609
      Location:25235
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    RNA

    1. NR_028136.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) includes the same 5' exon but differs in the remaining exons, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK128223, AK311154, AK314126, BC037924

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      124033341..124726325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006713815.3XP_006713878.1  kalirin isoform X16

      Conserved Domains (6) summary
      smart00150
      Location:11371237
      SPEC; Spectrin repeats
      smart00516
      Location:41179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12861456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:539720
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14631585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      pfam00169
      Location:14961581
      PH; PH domain
    2. XM_017007433.2XP_016862922.1  kalirin isoform X17

    3. XM_017007434.2XP_016862923.1  kalirin isoform X18

    4. XM_017007435.2XP_016862924.1  kalirin isoform X19

    5. XM_011513280.2XP_011511582.1  kalirin isoform X3

      Conserved Domains (16) summary
      cd00096
      Location:24892563
      Ig; Immunoglobulin domain
      cd11852
      Location:16511710
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23262384
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:26852939
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:41179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25702661
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12861456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8931131
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:24722566
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:14631585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21082242
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26912938
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00169
      Location:14961581
      PH; PH domain
      pfam00621
      Location:19342104
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17081933
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:11011240
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    6. XM_006713810.3XP_006713873.1  kalirin isoform X1

      Conserved Domains (16) summary
      cd00096
      Location:24902564
      Ig; Immunoglobulin domain
      cd11852
      Location:16511710
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23272385
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:26862940
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:41179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25712662
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12861456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8931131
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:24732567
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:14631585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21092243
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26922939
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00169
      Location:14961581
      PH; PH domain
      pfam00621
      Location:19352105
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17081934
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:11011240
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    7. XM_011513279.2XP_011511581.1  kalirin isoform X2

      Conserved Domains (16) summary
      cd00096
      Location:24892563
      Ig; Immunoglobulin domain
      cd11852
      Location:16511710
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23262384
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:26852939
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:41179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25702661
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12861456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8931131
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:24722566
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:14631585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21092243
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26912938
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00169
      Location:14961581
      PH; PH domain
      pfam00621
      Location:19352105
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17081934
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:11011240
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    8. XM_017007429.1XP_016862918.1  kalirin isoform X7

    9. XM_006713814.3XP_006713877.1  kalirin isoform X9

      Conserved Domains (16) summary
      cd00096
      Location:24582532
      Ig; Immunoglobulin domain
      cd11852
      Location:16511710
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:22952353
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:26542908
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:41179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25392630
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12861456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8931131
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:24412535
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:14631585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20772211
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26602907
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00169
      Location:14961581
      PH; PH domain
      pfam00621
      Location:19032073
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17081865
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:11011240
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    10. XM_017007430.1XP_016862919.1  kalirin isoform X10

    11. XM_006713811.3XP_006713874.1  kalirin isoform X4

      Conserved Domains (16) summary
      cd00096
      Location:24812555
      Ig; Immunoglobulin domain
      cd11852
      Location:16421701
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23182376
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:26772931
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:41179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25622653
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12771447
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8931122
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:24642558
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:14541576
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21002234
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26832930
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00169
      Location:14871572
      PH; PH domain
      pfam00621
      Location:19262096
      RhoGEF; RhoGEF domain
      pfam16609
      Location:16991925
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:11241293
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    12. XM_006713812.3XP_006713875.1  kalirin isoform X6

      Conserved Domains (16) summary
      cd00096
      Location:24772551
      Ig; Immunoglobulin domain
      cd11852
      Location:16381697
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23142372
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:26732927
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:41179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25582649
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12731443
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:539755
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:24602554
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:14501572
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20962230
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26792926
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00169
      Location:14831568
      PH; PH domain
      pfam00621
      Location:19222092
      RhoGEF; RhoGEF domain
      pfam16609
      Location:16951921
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:10881227
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    13. XM_006713813.3XP_006713876.1  kalirin isoform X8

      Conserved Domains (16) summary
      cd00096
      Location:24682542
      Ig; Immunoglobulin domain
      cd11852
      Location:16291688
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23052363
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:26642918
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:41179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25492640
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12641434
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8801109
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:24512545
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:14411563
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20872221
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26702917
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00169
      Location:14741559
      PH; PH domain
      pfam00621
      Location:19132083
      RhoGEF; RhoGEF domain
      pfam16609
      Location:16861912
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:11111280
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    14. XM_011513283.2XP_011511585.1  kalirin isoform X11

      Conserved Domains (11) summary
      cd11852
      Location:16511710
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23272385
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:41179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12861456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:539720
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14631585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21092243
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:14961581
      PH; PH domain
      pfam00621
      Location:19352105
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17081934
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:11011240
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    15. XM_011513285.2XP_011511587.1  kalirin isoform X13

      Conserved Domains (11) summary
      cd11852
      Location:16511710
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:22942352
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:41179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12861456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:539720
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14631585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20772211
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:14961581
      PH; PH domain
      pfam00621
      Location:19032073
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17081865
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:11011240
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    16. XM_017007431.1XP_016862920.1  kalirin isoform X12

    17. XM_017007432.1XP_016862921.1  kalirin isoform X14

    18. XM_024453811.1XP_024309579.1  kalirin isoform X15

      Conserved Domains (10) summary
      smart00150
      Location:11281228
      SPEC; Spectrin repeats
      cd11852
      Location:16421701
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:22842342
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:41179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12771447
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8931122
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14541576
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20672201
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:18932062
      RhoGEF; RhoGEF domain
      pfam16609
      Location:16991855
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    19. XM_011513281.3XP_011511583.1  kalirin isoform X5

      Related
      ENSP00000346122.4, ENST00000354186.8
      Conserved Domains (16) summary
      cd00096
      Location:24792553
      Ig; Immunoglobulin domain
      cd11852
      Location:16401699
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23162374
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:26752929
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:39177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25602651
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12751445
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8911120
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:24622556
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:14521574
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20982232
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26812928
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00169
      Location:14851570
      PH; PH domain
      pfam00621
      Location:19242094
      RhoGEF; RhoGEF domain
      pfam16609
      Location:16971923
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:11221291
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    RNA

    1. XR_001740356.1 RNA Sequence

    2. XR_001740357.1 RNA Sequence

    3. XR_001740358.1 RNA Sequence

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