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    PAPLN papilin, proteoglycan like sulfated glycoprotein [ Homo sapiens (human) ]

    Gene ID: 89932, updated on 16-Oct-2021

    Summary

    Official Symbol
    PAPLNprovided by HGNC
    Official Full Name
    papilin, proteoglycan like sulfated glycoproteinprovided by HGNC
    Primary source
    HGNC:HGNC:19262
    See related
    Ensembl:ENSG00000100767 MIM:617785
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PPN
    Expression
    Broad expression in spleen (RPKM 9.2), kidney (RPKM 8.9) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PAPLN in Genome Data Viewer
    Location:
    14q24.2
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (73235841..73274623)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (73704214..73741331)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene required for meiotic nuclear division 1 homolog (S. cerevisiae) pseudogene Neighboring gene RNA binding motif protein 25 Neighboring gene presenilin 1 Neighboring gene PAPLN antisense RNA 1 Neighboring gene RNA, U6 small nuclear 419, pseudogene Neighboring gene NUMB endocytic adaptor protein Neighboring gene uncharacterized LOC101928143

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC50452, DKFZp434F053

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365906.3NP_001352835.1  papilin isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC004846
      Related
      ENSP00000495882.2, ENST00000644200.2
      Conserved Domains (8) summary
      smart00209
      Location:2980
      TSP1; Thrombospondin type 1 repeats
      smart00409
      Location:11391219
      IG; Immunoglobulin
      pfam07679
      Location:10491119
      I-set; Immunoglobulin I-set domain
      pfam00014
      Location:753805
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam05986
      Location:183298
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:12351267
      PLAC; PLAC (protease and lacunin) domain
      pfam16626
      Location:814905
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cl11960
      Location:914978
      Ig; Immunoglobulin domain
    2. NM_001365907.2NP_001352836.1  papilin isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC004846
      Related
      ENSP00000451729.1, ENST00000555445.5
      Conserved Domains (8) summary
      smart00209
      Location:2980
      TSP1; Thrombospondin type 1 repeats
      smart00409
      Location:11231203
      IG; Immunoglobulin
      pfam07679
      Location:10331103
      I-set; Immunoglobulin I-set domain
      pfam00014
      Location:753789
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam05986
      Location:183298
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:12191251
      PLAC; PLAC (protease and lacunin) domain
      pfam16626
      Location:798889
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cl11960
      Location:898962
      Ig; Immunoglobulin domain
    3. NM_173462.4NP_775733.3  papilin isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC004846
      Consensus CDS
      CCDS32114.1
      UniProtKB/Swiss-Prot
      O95428
      UniProtKB/TrEMBL
      B3KXI1
      Related
      ENSP00000345395.5, ENST00000340738.9
      Conserved Domains (8) summary
      smart00408
      Location:10301089
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:2980
      TSP1; Thrombospondin type 1 repeats
      smart00410
      Location:10231102
      IG_like; Immunoglobulin like
      pfam00014
      Location:726778
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam05986
      Location:197271
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:12081240
      PLAC; PLAC (protease and lacunin) domain
      pfam16626
      Location:787878
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cl11960
      Location:887951
      Ig; Immunoglobulin domain

    RNA

    1. NR_158677.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC004846
    2. NR_158678.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC004846

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

      Range
      73235841..73274623
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537292.3XP_011535594.1  papilin isoform X1

      See identical proteins and their annotated locations for XP_011535594.1

      UniProtKB/Swiss-Prot
      O95428
      Related
      ENSP00000451803.1, ENST00000554301.5
      Conserved Domains (8) summary
      smart00209
      Location:2980
      TSP1; Thrombospondin type 1 repeats
      smart00409
      Location:11391219
      IG; Immunoglobulin
      pfam07679
      Location:10491119
      I-set; Immunoglobulin I-set domain
      pfam00014
      Location:753805
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam05986
      Location:183298
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:12351267
      PLAC; PLAC (protease and lacunin) domain
      pfam16626
      Location:814905
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cl11960
      Location:914978
      Ig; Immunoglobulin domain
    2. XM_011537291.3XP_011535593.1  papilin isoform X1

      See identical proteins and their annotated locations for XP_011535593.1

      UniProtKB/Swiss-Prot
      O95428
      Conserved Domains (8) summary
      smart00209
      Location:2980
      TSP1; Thrombospondin type 1 repeats
      smart00409
      Location:11391219
      IG; Immunoglobulin
      pfam07679
      Location:10491119
      I-set; Immunoglobulin I-set domain
      pfam00014
      Location:753805
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam05986
      Location:183298
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:12351267
      PLAC; PLAC (protease and lacunin) domain
      pfam16626
      Location:814905
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cl11960
      Location:914978
      Ig; Immunoglobulin domain
    3. XM_011537295.3XP_011535597.1  papilin isoform X4

      Conserved Domains (9) summary
      cd00096
      Location:10681144
      Ig; Immunoglobulin domain
      smart00209
      Location:3687
      TSP1; Thrombospondin type 1 repeats
      smart00410
      Location:9231001
      IG_like; Immunoglobulin like
      pfam07679
      Location:10561147
      I-set; Immunoglobulin I-set domain
      pfam00014
      Location:760812
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam05986
      Location:190305
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:11631195
      PLAC; PLAC (protease and lacunin) domain
      pfam16626
      Location:821912
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cl11960
      Location:921985
      Ig; Immunoglobulin domain
    4. XM_011537293.3XP_011535595.1  papilin isoform X2

      Conserved Domains (8) summary
      smart00408
      Location:10641123
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:3687
      TSP1; Thrombospondin type 1 repeats
      smart00409
      Location:9231001
      IG; Immunoglobulin
      smart00410
      Location:11461194
      IG_like; Immunoglobulin like
      cd00109
      Location:760811
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam05986
      Location:190305
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam16626
      Location:821912
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cd00096
      Location:10681072
      Ig; Ig strand B [structural motif]
    5. XM_017021749.2XP_016877238.1  papilin isoform X5

    6. XM_011537296.2XP_011535598.1  papilin isoform X7

      Related
      ENSP00000452455.1, ENST00000555123.5
      Conserved Domains (6) summary
      smart00209
      Location:3687
      TSP1; Thrombospondin type 1 repeats
      smart00410
      Location:9231001
      IG_like; Immunoglobulin like
      pfam00014
      Location:760812
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam05986
      Location:190305
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam16626
      Location:821912
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cl11960
      Location:921985
      Ig; Immunoglobulin domain
    7. XM_011537294.3XP_011535596.1  papilin isoform X3

      Conserved Domains (8) summary
      smart00408
      Location:10131072
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:264317
      TSP1; Thrombospondin type 1 repeats
      smart00410
      Location:10061085
      IG_like; Immunoglobulin like
      pfam00014
      Location:709761
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam05986
      Location:139254
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:11911223
      PLAC; PLAC (protease and lacunin) domain
      pfam16626
      Location:770861
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cl11960
      Location:870934
      Ig; Immunoglobulin domain

    RNA

    1. XR_429333.3 RNA Sequence

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