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    PGLYRP1 peptidoglycan recognition protein 1 [ Homo sapiens (human) ]

    Gene ID: 8993, updated on 17-Jun-2019

    Summary

    Official Symbol
    PGLYRP1provided by HGNC
    Official Full Name
    peptidoglycan recognition protein 1provided by HGNC
    Primary source
    HGNC:HGNC:8904
    See related
    Ensembl:ENSG00000008438 MIM:604963
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGRP; TAG7; PGRPS; PGLYRP; PGRP-S; TNFSF3L
    Expression
    Restricted expression toward bone marrow (RPKM 135.5) See more
    Orthologs

    Genomic context

    See PGLYRP1 in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (46019153..46023053, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46522411..46526556, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4903 Neighboring gene coiled-coil domain containing 61 Neighboring gene uncharacterized LOC105372421 Neighboring gene microRNA 769 Neighboring gene IGF like family member 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Antimicrobial peptides, organism-specific biosystem (from REACTOME)
      Antimicrobial peptides, organism-specific biosystemAntimicrobial peptides (AMPs) are small molecular weight proteins with broad spectrum of antimicrobial activity against bacteria, viruses, and fungi (Zasloff M 2002; Radek K & Gallo R 2007). The majo...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC126894, MGC126896

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    N-acetylmuramoyl-L-alanine amidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidoglycan receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidoglycan receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    antimicrobial humoral immune response mediated by antimicrobial peptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    antimicrobial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    antimicrobial humoral response TAS
    Traceable Author Statement
    more info
     
    defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    detection of bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    detection of bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth of symbiont in host IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    killing of cells of other organism IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    killing of cells of other organism IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interferon-gamma production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of natural killer cell differentiation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    pattern recognition receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    peptidoglycan catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytolysis in other organism IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cytolysis in other organism IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular exosome HDA PubMed 
    extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phagocytic vesicle lumen TAS
    Traceable Author Statement
    more info
     
    specific granule lumen TAS
    Traceable Author Statement
    more info
     
    tertiary granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    peptidoglycan recognition protein 1
    Names
    TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005091.3NP_005082.1  peptidoglycan recognition protein 1 precursor

      See identical proteins and their annotated locations for NP_005082.1

      Status: VALIDATED

      Source sequence(s)
      AF242517, DN998360
      Consensus CDS
      CCDS12680.1
      UniProtKB/Swiss-Prot
      O75594
      Related
      ENSP00000008938.3, ENST00000008938.5
      Conserved Domains (1) summary
      smart00701
      Location:31173
      PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      46019153..46023053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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