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    FATE1 fetal and adult testis expressed 1 [ Homo sapiens (human) ]

    Gene ID: 89885, updated on 17-Sep-2024

    Summary

    Official Symbol
    FATE1provided by HGNC
    Official Full Name
    fetal and adult testis expressed 1provided by HGNC
    Primary source
    HGNC:HGNC:24683
    See related
    Ensembl:ENSG00000147378 MIM:300450; AllianceGenome:HGNC:24683
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT43; FATE
    Summary
    This gene encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and other tumors and weakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primary spermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of early testicular differentiation and cell proliferation. [provided by RefSeq, Jan 2010]
    Expression
    Restricted expression toward testis (RPKM 120.2) See more
    Orthologs
    NEW
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    Genomic context

    See FATE1 in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (151716035..151723194)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (149984347..149991502)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (150884507..150891666)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene PAS domain containing repressor 1 Neighboring gene MPRA-validated peak7436 silencer Neighboring gene MPRA-validated peak7437 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21057 Neighboring gene proline rich and Gla domain 3 Neighboring gene cyclic nucleotide gated channel subunit alpha 2 Neighboring gene NANOG hESC enhancer GRCh37_chrX:150993617-150994163 Neighboring gene MAGEA4 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of fetal and adult testis expressed 1 (FATE1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondria-associated endoplasmic reticulum membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondria-associated endoplasmic reticulum membrane contact site IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    fetal and adult testis-expressed transcript protein
    Names
    BJ-HCC-2 antigen
    cancer/testis antigen 43
    tumor antigen BJ-HCC-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016398.1 RefSeqGene

      Range
      5000..12159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_033085.3NP_149076.1  fetal and adult testis-expressed transcript protein

      See identical proteins and their annotated locations for NP_149076.1

      Status: REVIEWED

      Source sequence(s)
      AF002992, AY101182
      Consensus CDS
      CCDS14700.1
      UniProtKB/Swiss-Prot
      Q969F0
      Related
      ENSP00000359375.3, ENST00000370350.7
      Conserved Domains (1) summary
      pfam05644
      Location:113182
      Miff; Mitochondrial and peroxisomal fission factor Mff

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      151716035..151723194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      149984347..149991502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)