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    TPD52L3 TPD52 like 3 [ Homo sapiens (human) ]

    Gene ID: 89882, updated on 17-Jun-2024

    Summary

    Official Symbol
    TPD52L3provided by HGNC
    Official Full Name
    TPD52 like 3provided by HGNC
    Primary source
    HGNC:HGNC:23382
    See related
    Ensembl:ENSG00000170777 MIM:617567; AllianceGenome:HGNC:23382
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    D55; hD55; TPD55; NYDSP25
    Summary
    This gene encodes a member of the tumor protein D52-like family of proteins. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. The encoded protein may play a role in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
    Expression
    Restricted expression toward testis (RPKM 52.1) See more
    Orthologs
    NEW
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    Genomic context

    See TPD52L3 in Genome Data Viewer
    Location:
    9p24.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (6328375..6331891)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (6333439..6336954)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (6328375..6331891)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19763 Neighboring gene interleukin 33 Neighboring gene selenoprotein T pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19766 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28186 Neighboring gene ubiquitin like with PHD and ring finger domains 2 Neighboring gene RNA, 7SL, cytoplasmic 25, pseudogene Neighboring gene glycine decarboxylase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC26757, MGC45374

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    tumor protein D55
    Names
    protein kinase NYD-SP25
    testis development protein NYD-SP25
    testis tissue sperm-binding protein Li 87P
    tumor protein D52 like 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001874.3NP_001001874.2  tumor protein D55 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL133480
      Consensus CDS
      CCDS34984.1
      UniProtKB/TrEMBL
      A0A140VKH0
      Related
      ENSP00000318665.3, ENST00000314556.4
      Conserved Domains (1) summary
      pfam04201
      Location:6127
      TPD52; tumor protein D52 family
    2. NM_001001875.4NP_001001875.2  tumor protein D55 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an internal segment, as compared to variant 1. It encodes isoform 3 which has a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AL133480
      Consensus CDS
      CCDS34985.1
      UniProtKB/TrEMBL
      A0A140VKH0
      Related
      ENSP00000370836.1, ENST00000381428.1
      Conserved Domains (1) summary
      pfam04201
      Location:6123
      TPD52; tumor protein D52 family
    3. NM_033516.6NP_277051.4  tumor protein D55 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL133480
      Consensus CDS
      CCDS34986.1
      UniProtKB/Swiss-Prot
      Q5TCR3, Q5TCR4, Q5TCR5, Q8N4P5, Q8WWF7, Q96J77, Q96M09
      UniProtKB/TrEMBL
      A0A140VKH0
      Related
      ENSP00000341677.5, ENST00000344545.6
      Conserved Domains (1) summary
      pfam04201
      Location:6136
      TPD52; tumor protein D52 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      6328375..6331891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017015280.3XP_016870769.1  tumor protein D55 isoform X1

      UniProtKB/TrEMBL
      A0A140VKH0
      Conserved Domains (1) summary
      pfam04201
      Location:6123
      TPD52; tumor protein D52 family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      6333439..6336954
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364142.1XP_054220117.1  tumor protein D55 isoform X1

      UniProtKB/TrEMBL
      A0A140VKH0