Format

Send to:

Choose Destination
    • Showing Current items.

    AQP10 aquaporin 10 [ Homo sapiens (human) ]

    Gene ID: 89872, updated on 12-May-2019

    Summary

    Official Symbol
    AQP10provided by HGNC
    Official Full Name
    aquaporin 10provided by HGNC
    Primary source
    HGNC:HGNC:16029
    See related
    Ensembl:ENSG00000143595 MIM:606578
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AQPA_HUMAN
    Summary
    This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in duodenum (RPKM 31.0) and small intestine (RPKM 22.0) See more
    Orthologs

    Genomic context

    See AQP10 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (154321059..154325325)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154293592..154297801)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 239, pseudogene Neighboring gene RNA, U6 small nuclear 121, pseudogene Neighboring gene ATPase phospholipid transporting 8B2 Neighboring gene RNA, U7 small nuclear 57 pseudogene Neighboring gene mitochondrial ribosomal protein S33 pseudogene 1 Neighboring gene ribosomal protein SA pseudogene 17

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    glycerol channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    urea transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    water channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to acidic pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycerol transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to toxic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    urea transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    water transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    water transport TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid droplet IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    aquaporin-10
    Names
    AQP-10
    aquaglyceroporin-10
    small intestine aquaporin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080429.3NP_536354.2  aquaporin-10

      See identical proteins and their annotated locations for NP_536354.2

      Status: REVIEWED

      Source sequence(s)
      AL162591, AL354980
      Consensus CDS
      CCDS1065.1
      UniProtKB/Swiss-Prot
      Q96PS8
      Related
      ENSP00000318355.3, ENST00000324978.8
      Conserved Domains (1) summary
      cl00200
      Location:13265
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      154321059..154325325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510104.2XP_011508406.1  aquaporin-10 isoform X1

      Conserved Domains (1) summary
      cl00200
      Location:13266
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    Support Center