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    AP1G2 adaptor related protein complex 1 subunit gamma 2 [ Homo sapiens (human) ]

    Gene ID: 8906, updated on 12-Jul-2019

    Summary

    Official Symbol
    AP1G2provided by HGNC
    Official Full Name
    adaptor related protein complex 1 subunit gamma 2provided by HGNC
    Primary source
    HGNC:HGNC:556
    See related
    Ensembl:ENSG00000213983 MIM:603534
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G2AD
    Summary
    Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. [provided by RefSeq, Aug 2017]
    Expression
    Ubiquitous expression in skin (RPKM 20.0), lymph node (RPKM 17.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See AP1G2 in Genome Data Viewer
    Location:
    14q11.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (23559565..23567939, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24028777..24038754, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene neuroguidin Neighboring gene thiamine triphosphatase Neighboring gene zinc finger homeobox 2 Neighboring gene uncharacterized LOC102724814 Neighboring gene junctophilin 4 Neighboring gene Sharpr-MPRA regulatory region 10629

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of adaptor-related protein complex 1, gamma 2 subunit (AP1G2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env The highly conserved C-terminal dileucine motif (residues 851-856) in the cytosolic domain of HIV-1 gp41 interacts with clathrin-associated AP-1 adaptor complexes PubMed
    env The cytoplasmic domain (residues 707-856) of HIV-1 gp41 interacts with whole clathrin-associated AP-1 and AP-2 adaptor complexes PubMed
    Nef nef Adaptor-related protein complex 1 (AP-1) is necessary for cross-presentation by MHC-I HLA-A and HLA-B molecules containing a cytoplasmic tail tyrosine signal and that HIV-1 Nef inhibits the cross-presentation in antigen-presenting cells PubMed
    nef Exogenous Nef and TNF-alpha synergistically activate NF-kappaB and AP-1 resulting in enhancing viral replication in both chronically infected promonocytic cells and acutely infected primary macrophages PubMed
    nef HIV-1 Nef stabilizes AP-1 complexes on endosomal membranes after ADP-ribosylation factor-1 (ARF1) -dependent attachment PubMed
    nef The dileucine motif (residues 164-165) in HIV-1 Nef is required for binding to AP-1 complexes and stabilizing their association with membranes PubMed
    nef A leucine-based motif near the C-terminus of HIV-1 Nef interacts with AP-1 complexes; residues 164 and 165 in Nef are required for the interaction with AP-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Clathrin derived vesicle budding, organism-specific biosystem (from REACTOME)
      Clathrin derived vesicle budding, organism-specific biosystemThere at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the cl...
    • Lysosome, organism-specific biosystem (from KEGG)
      Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
    • Lysosome, conserved biosystem (from KEGG)
      Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
    • Lysosome Vesicle Biogenesis, organism-specific biosystem (from REACTOME)
      Lysosome Vesicle Biogenesis, organism-specific biosystemProteins that have been synthesized, processed and sorted eventually reach the final steps of the secretory pathway. This pathway is responsible not only for proteins that are secreted from the cell ...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    • trans-Golgi Network Vesicle Budding, organism-specific biosystem (from REACTOME)
      trans-Golgi Network Vesicle Budding, organism-specific biosystemAfter passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membran...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    AP-1 adaptor complex TAS
    Traceable Author Statement
    more info
    PubMed 
    Golgi apparatus TAS
    Traceable Author Statement
    more info
    PubMed 
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    Golgi-associated vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transport vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    AP-1 complex subunit gamma-like 2
    Names
    adaptor related protein complex 1 gamma 2 subunit
    clathrin-associated/assembly/adaptor protein, large, gamma-2
    gamma2-adaptin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011937.1 RefSeqGene

      Range
      5235..13508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001282474.2NP_001269403.1  AP-1 complex subunit gamma-like 2 isoform 2

      See identical proteins and their annotated locations for NP_001269403.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' exon structure and thus differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AI497879, BG701521, BX161425
      UniProtKB/TrEMBL
      Q86U03
      Conserved Domains (2) summary
      pfam02883
      Location:291399
      Alpha_adaptinC2; Adaptin C-terminal domain
      cl26317
      Location:1194
      Adaptin_N; Adaptin N terminal region
    2. NM_001282475.2NP_001269404.1  AP-1 complex subunit gamma-like 2 isoform 3

      See identical proteins and their annotated locations for NP_001269404.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AL135999, BC051833, BI918958, H41406
      UniProtKB/TrEMBL
      Q86V28
      Conserved Domains (2) summary
      smart00809
      Location:600708
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:1503
      Adaptin_N; Adaptin N terminal region
    3. NM_001354673.2NP_001341602.1  AP-1 complex subunit gamma-like 2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AK304682, AL135999
      Conserved Domains (2) summary
      pfam01602
      Location:1446
      Adaptin_N; Adaptin N terminal region
      pfam02883
      Location:543651
      Alpha_adaptinC2; Adaptin C-terminal domain
    4. NM_001354674.2NP_001341603.1  AP-1 complex subunit gamma-like 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AK304682, AL135999
      Conserved Domains (2) summary
      pfam02883
      Location:291399
      Alpha_adaptinC2; Adaptin C-terminal domain
      cl26317
      Location:1194
      Adaptin_N; Adaptin N terminal region
    5. NM_001354675.2NP_001341604.1  AP-1 complex subunit gamma-like 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AK304682, AL135999
      Conserved Domains (2) summary
      pfam02883
      Location:291399
      Alpha_adaptinC2; Adaptin C-terminal domain
      cl26317
      Location:1194
      Adaptin_N; Adaptin N terminal region
    6. NM_001354677.2NP_001341606.1  AP-1 complex subunit gamma-like 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AK304682, AL135999
      Conserved Domains (2) summary
      pfam02883
      Location:291399
      Alpha_adaptinC2; Adaptin C-terminal domain
      cl26317
      Location:1194
      Adaptin_N; Adaptin N terminal region
    7. NM_001354681.2NP_001341610.1  AP-1 complex subunit gamma-like 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AK304682, AL135999
      Conserved Domains (2) summary
      pfam02883
      Location:291399
      Alpha_adaptinC2; Adaptin C-terminal domain
      cl26317
      Location:1194
      Adaptin_N; Adaptin N terminal region
    8. NM_003917.5NP_003908.1  AP-1 complex subunit gamma-like 2 isoform 1

      See identical proteins and their annotated locations for NP_003908.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB015318, BG701521, BQ073124
      Consensus CDS
      CCDS9602.1
      UniProtKB/Swiss-Prot
      O75843
      Related
      ENSP00000380309.3, ENST00000397120.7
      Conserved Domains (2) summary
      smart00809
      Location:672780
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:24575
      Adaptin_N; Adaptin N terminal region

    RNA

    1. NR_148937.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK304682, AL135999
    2. NR_148938.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK304682, AL135999

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

      Range
      23559565..23567939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005268173.3XP_005268230.1  AP-1 complex subunit gamma-like 2 isoform X5

      See identical proteins and their annotated locations for XP_005268230.1

      UniProtKB/Swiss-Prot
      O75843
      Conserved Domains (2) summary
      smart00809
      Location:672780
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:24575
      Adaptin_N; Adaptin N terminal region
    2. XM_005268170.3XP_005268227.1  AP-1 complex subunit gamma-like 2 isoform X1

      See identical proteins and their annotated locations for XP_005268227.1

      Conserved Domains (2) summary
      smart00809
      Location:729837
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:24632
      Adaptin_N; Adaptin N terminal region
    3. XM_005268174.3XP_005268231.1  AP-1 complex subunit gamma-like 2 isoform X6

      See identical proteins and their annotated locations for XP_005268231.1

      Conserved Domains (2) summary
      smart00809
      Location:600708
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:1503
      Adaptin_N; Adaptin N terminal region
    4. XM_005268167.3XP_005268224.1  AP-1 complex subunit gamma-like 2 isoform X1

      See identical proteins and their annotated locations for XP_005268224.1

      Conserved Domains (2) summary
      smart00809
      Location:729837
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:24632
      Adaptin_N; Adaptin N terminal region
    5. XM_006720301.3XP_006720364.1  AP-1 complex subunit gamma-like 2 isoform X1

      See identical proteins and their annotated locations for XP_006720364.1

      Conserved Domains (2) summary
      smart00809
      Location:729837
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:24632
      Adaptin_N; Adaptin N terminal region
    6. XM_005268180.4XP_005268237.1  AP-1 complex subunit gamma-like 2 isoform X8

      See identical proteins and their annotated locations for XP_005268237.1

      UniProtKB/TrEMBL
      Q86V28
      Conserved Domains (2) summary
      pfam02883
      Location:527635
      Alpha_adaptinC2; Adaptin C-terminal domain
      cl26317
      Location:43430
      Adaptin_N; Adaptin N terminal region
    7. XM_005268175.3XP_005268232.1  AP-1 complex subunit gamma-like 2 isoform X6

      See identical proteins and their annotated locations for XP_005268232.1

      Conserved Domains (2) summary
      smart00809
      Location:600708
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:1503
      Adaptin_N; Adaptin N terminal region
    8. XM_005268172.3XP_005268229.1  AP-1 complex subunit gamma-like 2 isoform X5

      See identical proteins and their annotated locations for XP_005268229.1

      UniProtKB/Swiss-Prot
      O75843
      Conserved Domains (2) summary
      smart00809
      Location:672780
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:24575
      Adaptin_N; Adaptin N terminal region
    9. XM_005268169.3XP_005268226.1  AP-1 complex subunit gamma-like 2 isoform X1

      See identical proteins and their annotated locations for XP_005268226.1

      Conserved Domains (2) summary
      smart00809
      Location:729837
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:24632
      Adaptin_N; Adaptin N terminal region
    10. XM_005268182.3XP_005268239.1  AP-1 complex subunit gamma-like 2 isoform X9

      Conserved Domains (2) summary
      smart00809
      Location:462570
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:1365
      Adaptin_N; Adaptin N terminal region
    11. XM_017021741.1XP_016877230.1  AP-1 complex subunit gamma-like 2 isoform X4

    12. XM_024449738.1XP_024305506.1  AP-1 complex subunit gamma-like 2 isoform X11

      Conserved Domains (2) summary
      pfam02883
      Location:291399
      Alpha_adaptinC2; Adaptin C-terminal domain
      cl26317
      Location:1194
      Adaptin_N; Adaptin N terminal region
    13. XM_005268179.3XP_005268236.1  AP-1 complex subunit gamma-like 2 isoform X7

      See identical proteins and their annotated locations for XP_005268236.1

      Conserved Domains (2) summary
      pfam01602
      Location:1446
      Adaptin_N; Adaptin N terminal region
      pfam02883
      Location:543651
      Alpha_adaptinC2; Adaptin C-terminal domain
    14. XM_005268178.4XP_005268235.1  AP-1 complex subunit gamma-like 2 isoform X7

      See identical proteins and their annotated locations for XP_005268235.1

      Conserved Domains (2) summary
      pfam01602
      Location:1446
      Adaptin_N; Adaptin N terminal region
      pfam02883
      Location:543651
      Alpha_adaptinC2; Adaptin C-terminal domain
    15. XM_017021742.2XP_016877231.1  AP-1 complex subunit gamma-like 2 isoform X6

      Conserved Domains (2) summary
      smart00809
      Location:600708
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:1503
      Adaptin_N; Adaptin N terminal region
    16. XM_005268168.5XP_005268225.1  AP-1 complex subunit gamma-like 2 isoform X1

      See identical proteins and their annotated locations for XP_005268225.1

      Conserved Domains (2) summary
      smart00809
      Location:729837
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:24632
      Adaptin_N; Adaptin N terminal region
    17. XM_011537283.3XP_011535585.1  AP-1 complex subunit gamma-like 2 isoform X2

      Conserved Domains (2) summary
      smart00809
      Location:694802
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:24600
      Adaptin_N; Adaptin N terminal region
    18. XM_017021740.1XP_016877229.1  AP-1 complex subunit gamma-like 2 isoform X3

    19. XM_017021745.1XP_016877234.1  AP-1 complex subunit gamma-like 2 isoform X10

    RNA

    1. XR_001750584.2 RNA Sequence

    2. XR_001750588.2 RNA Sequence

    3. XR_001750583.2 RNA Sequence

      Related
      ENST00000535852.6
    4. XR_002957567.1 RNA Sequence

    5. XR_001750590.2 RNA Sequence

      Related
      ENST00000460049.6
    6. XR_002957569.1 RNA Sequence

    7. XR_002957568.1 RNA Sequence

    8. XR_001750589.1 RNA Sequence

      Related
      ENST00000465445.6
    9. XR_002957570.1 RNA Sequence

    10. XR_001750586.1 RNA Sequence

    11. XR_001750587.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_080545.1: Suppressed sequence

      Description
      NM_080545.1: This RefSeq was temporarily suppressed because insufficient data to support this transcript currently exist.
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