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    PRP4K pre-mRNA processing factor kinase PRP4K [ Homo sapiens (human) ]

    Gene ID: 8899, updated on 18-Sep-2024

    Summary

    Official Symbol
    PRP4Kprovided by HGNC
    Official Full Name
    pre-mRNA processing factor kinase PRP4Kprovided by HGNC
    Primary source
    HGNC:HGNC:17346
    See related
    Ensembl:ENSG00000112739 MIM:602338; AllianceGenome:HGNC:17346
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PR4H; PRP4; PRP4H; Prp4B; PRPF4B; dJ1013A10.1
    Summary
    Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 15.0), lymph node (RPKM 13.5) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PRP4K in Genome Data Viewer
    Location:
    6p25.2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (4021300..4064983)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (3890936..3934285)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (4021534..4065217)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 14796 Neighboring gene glutaredoxin 3 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:3990981-3991480 Neighboring gene uncharacterized LOC124901245 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23896 Neighboring gene Sharpr-MPRA regulatory region 2502 Neighboring gene uncharacterized LOC124901553 Neighboring gene family with sequence similarity 217 member A Neighboring gene testis expressed 56, pseudogene Neighboring gene Sharpr-MPRA regulatory region 9692 Neighboring gene enoyl-CoA delta isomerase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, pre-mRNA processing factor 4 homolog B (PRPF4B), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with PRPF4B is increased by RRE PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human PRP4 pre-mRNA processing factor 4 homolog B (yeast) (PRPF4B) at amino acid residues 105-106 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0536

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding HDA PubMed 
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase PRP4 homolog
    Names
    PRP4 kinase
    PRP4 pre-mRNA processing factor 4 homolog B
    PRP4 pre-mRNA-processing factor 4 homolog
    dJ1013A10.1 (PRP4 protein kinase homolog)
    pre-mRNA processing factor 4B
    protein-serine/threonine kinase
    NP_003904.3
    XP_011513272.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003913.5NP_003904.3  serine/threonine-protein kinase PRP4 homolog

      See identical proteins and their annotated locations for NP_003904.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      AL033383, AL138831, AY029347, CN314758, CN314761
      Consensus CDS
      CCDS4488.1
      UniProtKB/Swiss-Prot
      A8K5C9, Q13523, Q5D0F6, Q5TAY8, Q8IVC3, Q8TDP2, Q96QT7, Q9UEE6
      UniProtKB/TrEMBL
      B4DZQ5
      Related
      ENSP00000337194.6, ENST00000337659.11
      Conserved Domains (3) summary
      PHA03307
      Location:283427
      PHA03307; transcriptional regulator ICP4; Provisional
      PTZ00108
      Location:170381
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      cd14135
      Location:6861003
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4

    RNA

    1. NR_146783.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL033383, AL138831
    2. NR_146784.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL033383, AL138831
    3. NR_146785.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL033383, AL138831

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      4021300..4064983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514970.4XP_011513272.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/TrEMBL
      B4DZQ5
      Conserved Domains (1) summary
      cl21453
      Location:686822
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_007059353.1 RNA Sequence

    2. XR_007059354.1 RNA Sequence

    3. XR_007059355.1 RNA Sequence

    4. XR_007059356.1 RNA Sequence

    5. XR_007059363.1 RNA Sequence

    6. XR_007059365.1 RNA Sequence

    7. XR_007059357.1 RNA Sequence

    8. XR_007059361.1 RNA Sequence

    9. XR_007059358.1 RNA Sequence

    10. XR_007059362.1 RNA Sequence

    11. XR_007059360.1 RNA Sequence

    12. XR_007059367.1 RNA Sequence

    13. XR_007059366.1 RNA Sequence

    14. XR_007059364.1 RNA Sequence

    15. XR_007059359.1 RNA Sequence

    16. XR_007059370.1 RNA Sequence

    17. XR_007059368.1 RNA Sequence

    18. XR_007059373.1 RNA Sequence

    19. XR_007059369.1 RNA Sequence

    20. XR_007059371.1 RNA Sequence

    21. XR_007059376.1 RNA Sequence

    22. XR_007059375.1 RNA Sequence

    23. XR_007059372.1 RNA Sequence

    24. XR_007059377.1 RNA Sequence

    25. XR_007059381.1 RNA Sequence

    26. XR_007059374.1 RNA Sequence

    27. XR_007059379.1 RNA Sequence

    28. XR_007059378.1 RNA Sequence

    29. XR_007059380.1 RNA Sequence

    30. XR_007059382.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      3890936..3934285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008487457.1 RNA Sequence

    2. XR_008487458.1 RNA Sequence

    3. XR_008487459.1 RNA Sequence

    4. XR_008487460.1 RNA Sequence

    5. XR_008487461.1 RNA Sequence

    6. XR_008487462.1 RNA Sequence

    7. XR_008487465.1 RNA Sequence

    8. XR_008487476.1 RNA Sequence

    9. XR_008487479.1 RNA Sequence

    10. XR_008487463.1 RNA Sequence

    11. XR_008487464.1 RNA Sequence

    12. XR_008487468.1 RNA Sequence

    13. XR_008487466.1 RNA Sequence

    14. XR_008487475.1 RNA Sequence

    15. XR_008487473.1 RNA Sequence

    16. XR_008487469.1 RNA Sequence

    17. XR_008487474.1 RNA Sequence

    18. XR_008487472.1 RNA Sequence

    19. XR_008487481.1 RNA Sequence

    20. XR_008487480.1 RNA Sequence

    21. XR_008487467.1 RNA Sequence

    22. XR_008487477.1 RNA Sequence

    23. XR_008487478.1 RNA Sequence

    24. XR_008487470.1 RNA Sequence

    25. XR_008487471.1 RNA Sequence

    26. XR_008487485.1 RNA Sequence

    27. XR_008487486.1 RNA Sequence

    28. XR_008487484.1 RNA Sequence

    29. XR_008487482.1 RNA Sequence

    30. XR_008487488.1 RNA Sequence

    31. XR_008487490.1 RNA Sequence

    32. XR_008487483.1 RNA Sequence

    33. XR_008487487.1 RNA Sequence

    34. XR_008487495.1 RNA Sequence

    35. XR_008487491.1 RNA Sequence

    36. XR_008487492.1 RNA Sequence

    37. XR_008487494.1 RNA Sequence

    38. XR_008487489.1 RNA Sequence

    39. XR_008487499.1 RNA Sequence

    40. XR_008487496.1 RNA Sequence

    41. XR_008487501.1 RNA Sequence

    42. XR_008487493.1 RNA Sequence

    43. XR_008487498.1 RNA Sequence

    44. XR_008487497.1 RNA Sequence

    45. XR_008487500.1 RNA Sequence

    46. XR_008487502.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_176800.2: Suppressed sequence

      Description
      NM_176800.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.