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    TMEM11 transmembrane protein 11 [ Homo sapiens (human) ]

    Gene ID: 8834, updated on 27-Nov-2024

    Summary

    Official Symbol
    TMEM11provided by HGNC
    Official Full Name
    transmembrane protein 11provided by HGNC
    Primary source
    HGNC:HGNC:16823
    See related
    Ensembl:ENSG00000178307 MIM:618817; AllianceGenome:HGNC:16823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PM1; PMI; C17orf35
    Summary
    Involved in mitochondrion organization. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in fat (RPKM 9.9), bone marrow (RPKM 9.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TMEM11 in Genome Data Viewer
    Location:
    17p11.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (21197954..21214161, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (21146829..21163052, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (21101267..21117474, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:20978550-20979050 Neighboring gene long intergenic non-protein coding RNA 1563 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:20987896-20989095 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr17:21002173-21002789 and GRCh37_chr17:21002790-21003407 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:21011664-21012527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11879 Neighboring gene dehydrogenase/reductase 7B Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:21102215-21103012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:21108419-21109051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11880 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11881 Neighboring gene TMEM11 divergent transcript Neighboring gene RNA, 7SL, cytoplasmic 426, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr is identified to have a physical interaction with transmembrane protein 11 (TMEM11) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: NATD1

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in inner mitochondrial membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    transmembrane protein 11, mitochondrial
    Names
    putative receptor protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003876.3NP_003867.1  transmembrane protein 11, mitochondrial

      See identical proteins and their annotated locations for NP_003867.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AC087294, AC087393
      Consensus CDS
      CCDS11216.1
      UniProtKB/Swiss-Prot
      P17152, Q53YB2
      Related
      ENSP00000319992.6, ENST00000317635.6
      Conserved Domains (1) summary
      pfam14972
      Location:28190
      Mito_morph_reg; Mitochondrial morphogenesis regulator

    RNA

    1. NR_024547.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC087294, AC087393
      Related
      ENST00000577419.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      21197954..21214161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      21146829..21163052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)