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    SUCLG2 succinate-CoA ligase GDP-forming subunit beta [ Homo sapiens (human) ]

    Gene ID: 8801, updated on 7-Apr-2024

    Summary

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    Official Symbol
    SUCLG2provided by HGNC
    Official Full Name
    succinate-CoA ligase GDP-forming subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:11450
    See related
    Ensembl:ENSG00000172340 MIM:603922; AllianceGenome:HGNC:11450
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G-SCS; GBETA; GTPSCS
    Summary
    This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010]
    Expression
    Ubiquitous expression in colon (RPKM 21.2), kidney (RPKM 16.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    3p14.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (67360460..67654612, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (67405452..67699926, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (67410884..67705036, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112267879 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:67346086-67347285 Neighboring gene microRNA 4272 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:67494181-67494886 Neighboring gene MPRA-validated peak4691 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr3:67603587-67603736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20048 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 7041 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20049 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:67704843-67705342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14513 Neighboring gene SUCLG2 divergent transcript Neighboring gene FAM19A1 intron homotypic cluster of transcription factor binding sites enhancer Neighboring gene TAFA chemokine like family member 1 Neighboring gene COP9 signalosome subunit 8 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells. Wu B, et al. Cell Metab, 2020 Dec 1. PMID 33264602, Free PMC Article
    2. Identification of novel biomarker and therapeutic target candidates for diagnosis and treatment of follicular carcinoma. Lai X, et al. J Proteomics, 2017 Aug 23. PMID 28709933
    3. The interplay between SUCLA2, SUCLG2, and mitochondrial DNA depletion. Miller C, et al. Biochim Biophys Acta, 2011 May. PMID 21295139
    4. A Fast Implementation of a Scan Statistic for Identifying Chromosomal Patterns of Genome Wide Association Studies. Sun YV, et al. Comput Stat Data Anal, 2009 Mar 15. PMID 20161066, Free PMC Article
    5. EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer. Lin SR, et al. Oncogene, 2020 Oct. PMID 32963351

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells.
      Title: Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells.
    2. EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer.
      Title: EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer.
    3. SUCLG2 has a sensitivity of 75% and a specificity of 80% to distinguish follicular carcinoma from follicular adenoma
      Title: Identification of novel biomarker and therapeutic target candidates for diagnosis and treatment of follicular carcinoma.
    4. The absence of SUCLA2 and SUCLG2 in human glia is in compliance with the presence of alternative pathways occurring in these cells, namely the GABA shunt and ketone body metabolism
      Title: Localization of SUCLA2 and SUCLG2 subunits of succinyl CoA ligase within the cerebral cortex suggests the absence of matrix substrate-level phosphorylation in glial cells of the human brain.
    5. SUCLG2 has been identified as both a determinator of CSF amyloid beta-protein (1-42) levels and as attenuator of cognitive decline in Alzheimer's disease.
      Title: SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.
    6. Loss of SUCLG2 is associated with mitochondrial DNA depletion and results in mitochondrial depletion syndrome.
      Title: The interplay between SUCLA2, SUCLG2, and mitochondrial DNA depletion.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    9. Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: A Fast Implementation of a Scan Statistic for Identifying Chromosomal Patterns of Genome Wide Association Studies.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.
    EBI GWAS Catalog
    An atlas of genetic influences on human blood metabolites.
    EBI GWAS Catalog
    Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism.
    EBI GWAS Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog
    SUCLG2 identified as both a determinator of CSF Aß1-42-levels and an attenuator of cognitive decline in Alzheimer's disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of succinate-CoA ligase, GDP-forming, beta subunit (SUCLG2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with succinate-CoA ligase, GDP-forming, beta subunit (SUCLG2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    integrase gag-pol HIV-1 IN is identified to have a physical interaction with succinate-CoA ligase, GDP-forming, beta subunit (SUCLG2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables succinate-CoA ligase (ADP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate-CoA ligase (GDP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate-CoA ligase (GDP-forming) activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in succinate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in succinyl-CoA catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in succinyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in succinyl-CoA metabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in mitochondrion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    part_of succinate-CoA ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of succinate-CoA ligase complex (GDP-forming) IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
    Names
    GTP-specific succinyl-CoA synthetase beta subunit
    GTP-specific succinyl-CoA synthetase subunit beta
    SCS-betaG
    succinate-CoA ligase GDP-forming beta subunit
    succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
    succinyl-CoA ligase, GDP-forming, beta chain, mitochondrial
    succinyl-CoA synthetase, beta-G chain
    NP_001171070.1
    NP_003839.2
    XP_016862909.1
    XP_047305096.1
    XP_054204242.1
    XP_054204243.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052945.1 RefSeqGene

      Range
      5003..284896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001177599.2 → NP_001171070.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC112213, AK310527, BC068602
      Consensus CDS
      CCDS54605.1
      UniProtKB/TrEMBL
      E9PDQ8
      Related
      ENSP00000419325.1, ENST00000493112.5
      Conserved Domains (3) summary
      PRK00696
      Location:39 → 396
      sucC; succinyl-CoA synthetase subunit beta; Provisional
      pfam00549
      Location:306 → 396
      Ligase_CoA; CoA-ligase
      pfam08442
      Location:39 → 247
      ATP-grasp_2; ATP-grasp domain

    2. NM_003848.4 → NP_003839.2  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 2 precursor

      See identical proteins and their annotated locations for NP_003839.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR, and 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AF131748, BC007716, BC068602
      Consensus CDS
      CCDS43104.1
      UniProtKB/Swiss-Prot
      C9JVT2, O95195, Q6NUH7, Q86VX8, Q8WUQ1, Q96I99
      UniProtKB/TrEMBL
      Q3ZCW5
      Related
      ENSP00000307432.5, ENST00000307227.10
      Conserved Domains (3) summary
      PRK00696
      Location:39 → 420
      sucC; succinyl-CoA synthetase subunit beta; Provisional
      pfam00549
      Location:306 → 420
      Ligase_CoA; CoA-ligase
      pfam08442
      Location:39 → 247
      ATP-grasp_2; ATP-grasp domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      67360460..67654612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007420.3 → XP_016862909.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform X1

      UniProtKB/TrEMBL
      E9PDQ8
      Related
      ENSP00000417589.1, ENST00000492795.1

    2. XM_047449140.1 → XP_047305096.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform X2

    RNA

    1. XR_007095763.1 RNA Sequence

    2. XR_001740350.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      67405452..67699926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348267.1 → XP_054204242.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform X1

    2. XM_054348268.1 → XP_054204243.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform X2

    RNA

    1. XR_008486847.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96I99.2 GenPept UniProtKB/Swiss-Prot:Q96I99

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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