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    MPDZ multiple PDZ domain crumbs cell polarity complex component [ Homo sapiens (human) ]

    Gene ID: 8777, updated on 8-Jul-2021

    Summary

    Official Symbol
    MPDZprovided by HGNC
    Official Full Name
    multiple PDZ domain crumbs cell polarity complex componentprovided by HGNC
    Primary source
    HGNC:HGNC:7208
    See related
    Ensembl:ENSG00000107186 MIM:603785
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HYC2; MUPP1
    Summary
    The protein encoded by this gene has multiple PDZ domains, which are hallmarks of protein-protein interactions. The encoded protein is known to interact with the HTR2C receptor and may cause it to clump at the cell surface. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
    Expression
    Ubiquitous expression in liver (RPKM 12.7), fat (RPKM 10.5) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MPDZ in Genome Data Viewer
    Location:
    9p23
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (13105296..13279692, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (13105706..13279691, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987047 Neighboring gene lupus La protein pseudogene Neighboring gene long intergenic non-protein coding RNA 1235 Neighboring gene uncharacterized LOC105375977

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
    GeneReviews: Not available
    Hydrocephalus, congenital, 2, with or without brain or eye anomalies
    MedGen: C3554691 OMIM: 615219 GeneReviews: Not available
    Compare labs

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of multiple PDZ domain protein (MPDZ) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ25909, FLJ34626, FLJ90240, DKFZp781P216

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in microtubule organizing center organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in tight junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in apical part of cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apicolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    multiple PDZ domain protein
    Names
    multi-PDZ domain protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042810.1 RefSeqGene

      Range
      5001..178861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001261406.2NP_001248335.1  multiple PDZ domain protein isoform 2

      See identical proteins and their annotated locations for NP_001248335.1

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS59120.1
      UniProtKB/Swiss-Prot
      O75970
      Related
      ENSP00000415208.1, ENST00000447879.6
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:15291593
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    2. NM_001261407.2NP_001248336.1  multiple PDZ domain protein isoform 3

      See identical proteins and their annotated locations for NP_001248336.1

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS59119.1
      UniProtKB/Swiss-Prot
      O75970
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:15291593
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    3. NM_001330637.2NP_001317566.1  multiple PDZ domain protein isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS83342.1
      UniProtKB/Swiss-Prot
      O75970
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2; L27_2
      pfam16667
      Location:15621626
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    4. NM_001375413.1NP_001362342.1  multiple PDZ domain protein isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:15951659
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    5. NM_001375416.1NP_001362345.1  multiple PDZ domain protein isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:15291593
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    6. NM_001375417.1NP_001362346.1  multiple PDZ domain protein isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:15291593
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    7. NM_001375418.1NP_001362347.1  multiple PDZ domain protein isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:15291593
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    8. NM_001375419.1NP_001362348.1  multiple PDZ domain protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:15291593
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    9. NM_001375420.1NP_001362349.1  multiple PDZ domain protein isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:19161999
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:14921556
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    10. NM_001375421.1NP_001362350.1  multiple PDZ domain protein isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:19161999
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:14921556
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    11. NM_001375422.1NP_001362351.1  multiple PDZ domain protein isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:19161999
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:14921556
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    12. NM_001375423.1NP_001362352.1  multiple PDZ domain protein isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:19161999
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:14921556
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    13. NM_001375424.1NP_001362353.1  multiple PDZ domain protein isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:19161999
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:14921556
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    14. NM_001375425.1NP_001362354.1  multiple PDZ domain protein isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:18871970
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:14921556
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    15. NM_001375426.1NP_001362355.1  multiple PDZ domain protein isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:18871970
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:14921556
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    16. NM_001375427.1NP_001362356.1  multiple PDZ domain protein isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:18501933
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:14261490
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    17. NM_001378778.1NP_001365707.1  multiple PDZ domain protein isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Related
      ENSP00000320006.7, ENST00000319217.12
    18. NM_003829.5NP_003820.2  multiple PDZ domain protein isoform 1

      See identical proteins and their annotated locations for NP_003820.2

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS47951.1
      UniProtKB/Swiss-Prot
      O75970
      Related
      ENSP00000439807.1, ENST00000541718.5
      Conserved Domains (4) summary
      pfam09045
      Location:663
      L27_2; L27_2
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16667
      Location:15621626
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      13105296..13279692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006716886.3XP_006716949.1  multiple PDZ domain protein isoform X1

      See identical proteins and their annotated locations for XP_006716949.1

      UniProtKB/Swiss-Prot
      O75970
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2; L27_2
      pfam16667
      Location:15621626
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    2. XM_017015252.1XP_016870741.1  multiple PDZ domain protein isoform X2

    3. XM_006716888.3XP_006716951.1  multiple PDZ domain protein isoform X3

      See identical proteins and their annotated locations for XP_006716951.1

      UniProtKB/Swiss-Prot
      O75970
      Conserved Domains (4) summary
      pfam09045
      Location:663
      L27_2; L27_2
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16667
      Location:15621626
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    4. XM_017015253.1XP_016870742.1  multiple PDZ domain protein isoform X5

      UniProtKB/Swiss-Prot
      O75970
      Related
      ENSP00000444151.1, ENST00000536827.5
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:15291593
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    5. XM_024447708.1XP_024303476.1  multiple PDZ domain protein isoform X1

      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2; L27_2
      pfam16667
      Location:15621626
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    6. XM_006716887.4XP_006716950.1  multiple PDZ domain protein isoform X1

      See identical proteins and their annotated locations for XP_006716950.1

      UniProtKB/Swiss-Prot
      O75970
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2; L27_2
      pfam16667
      Location:15621626
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    7. XM_017015258.1XP_016870747.1  multiple PDZ domain protein isoform X8

    8. XM_017015259.1XP_016870748.1  multiple PDZ domain protein isoform X9

    RNA

    1. XR_002956817.1 RNA Sequence

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