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    TNFRSF14 TNF receptor superfamily member 14 [ Homo sapiens (human) ]

    Gene ID: 8764, updated on 17-Jun-2024

    Summary

    Official Symbol
    TNFRSF14provided by HGNC
    Official Full Name
    TNF receptor superfamily member 14provided by HGNC
    Primary source
    HGNC:HGNC:11912
    See related
    Ensembl:ENSG00000157873 MIM:602746; AllianceGenome:HGNC:11912
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TR2; ATAR; HVEA; HVEM; CD270; LIGHTR
    Summary
    This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
    Expression
    Ubiquitous expression in spleen (RPKM 22.9), duodenum (RPKM 21.7) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TNFRSF14 in Genome Data Viewer
    Location:
    1p36.32
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (2554234..2563829)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (1997007..2005473)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (2487810..2495268)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene pantothenate kinase 4 (inactive) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2454755-2455542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2458062-2458782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2459504-2460224 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:2460225-2460944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2461459-2461962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2463669-2464169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2465753-2466256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2466257-2466760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2466761-2467264 Neighboring gene hes family bHLH transcription factor 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2474412-2475282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2476154-2477024 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2479637-2480506 Neighboring gene TNFRSF14 antisense RNA 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:2481723-2482922 Neighboring gene uncharacterized LOC100996583 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2498904-2499776 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2508969-2509605 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2519024-2519656 Neighboring gene peroxiredoxin like 2B Neighboring gene membrane metalloendopeptidase like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
    EBI GWAS Catalog
    Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    EBI GWAS Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    EBI GWAS Catalog
    Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of tumor necrosis factor receptor superfamily, member 14 (TNFRSF14) in human B cells PubMed
    Vif vif HIV-1 Vif downregulates the expression of tumor necrosis factor receptor superfamily, member 14 (TNFRSF14) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ26662

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tumor necrosis factor receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in T cell costimulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in defense response to Gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of adaptive immune memory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of alpha-beta T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of T cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cytokine production involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor receptor superfamily member 14
    Names
    CD40-like protein
    herpes virus entry mediator A
    tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
    tumor necrosis factor receptor-like gene2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047096.1 RefSeqGene

      Range
      5007..12465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297605.2NP_001284534.1  tumor necrosis factor receptor superfamily member 14 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      BX343044, CD366981, DC383433
      UniProtKB/TrEMBL
      F6UPZ7
      Conserved Domains (1) summary
      cd10582
      Location:42142
      TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
    2. NM_003820.4NP_003811.2  tumor necrosis factor receptor superfamily member 14 isoform 1 precursor

      See identical proteins and their annotated locations for NP_003811.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CD366981, DC383433, U70321
      Consensus CDS
      CCDS44046.1
      UniProtKB/Swiss-Prot
      B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65
      UniProtKB/TrEMBL
      F6Q0M4
      Related
      ENSP00000347948.4, ENST00000355716.5
      Conserved Domains (3) summary
      cd00185
      Location:138186
      TNFRSF; CRD2 [structural motif]
      cd10582
      Location:42142
      TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
      cl22855
      Location:98196
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      2554234..2563829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433419.1XP_047289375.1  tumor necrosis factor receptor superfamily member 14 isoform X1

      UniProtKB/Swiss-Prot
      B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65
      UniProtKB/TrEMBL
      F6Q0M4
    2. XM_047433418.1XP_047289374.1  tumor necrosis factor receptor superfamily member 14 isoform X1

      UniProtKB/Swiss-Prot
      B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65
      UniProtKB/TrEMBL
      F6Q0M4
    3. XM_047433414.1XP_047289370.1  tumor necrosis factor receptor superfamily member 14 isoform X1

      UniProtKB/Swiss-Prot
      B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65
      UniProtKB/TrEMBL
      F6Q0M4
    4. XM_047433412.1XP_047289368.1  tumor necrosis factor receptor superfamily member 14 isoform X1

      UniProtKB/Swiss-Prot
      B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65
      UniProtKB/TrEMBL
      F6Q0M4
      Related
      ENSP00000399292.2, ENST00000435221.6
    5. XM_047433416.1XP_047289372.1  tumor necrosis factor receptor superfamily member 14 isoform X1

      UniProtKB/Swiss-Prot
      B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65
      UniProtKB/TrEMBL
      F6Q0M4
      Related
      ENSP00000399533.1, ENST00000451778.5
    6. XM_047433413.1XP_047289369.1  tumor necrosis factor receptor superfamily member 14 isoform X1

      UniProtKB/Swiss-Prot
      B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65
      UniProtKB/TrEMBL
      F6Q0M4
      Related
      ENSP00000415254.1, ENST00000434817.5
    7. XM_047433422.1XP_047289378.1  tumor necrosis factor receptor superfamily member 14 isoform X4

      UniProtKB/TrEMBL
      B9A034, F6UPZ7
      Related
      ENSP00000386859.1, ENST00000409119.5
    8. XM_006711019.3XP_006711082.1  tumor necrosis factor receptor superfamily member 14 isoform X3

      See identical proteins and their annotated locations for XP_006711082.1

      UniProtKB/TrEMBL
      F6UPZ7
      Conserved Domains (1) summary
      cd10582
      Location:42142
      TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
    9. XM_047433421.1XP_047289377.1  tumor necrosis factor receptor superfamily member 14 isoform X4

      UniProtKB/TrEMBL
      B9A034, F6UPZ7
      Related
      ENSP00000411854.1, ENST00000426449.5
    10. XM_047433423.1XP_047289379.1  tumor necrosis factor receptor superfamily member 14 isoform X5

      UniProtKB/TrEMBL
      B4DU65, E9PHP3
    11. XM_011542383.3XP_011540685.1  tumor necrosis factor receptor superfamily member 14 isoform X2

      See identical proteins and their annotated locations for XP_011540685.1

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187515.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      106553..115019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328613.1XP_054184588.1  tumor necrosis factor receptor superfamily member 14 isoform X1

      UniProtKB/Swiss-Prot
      B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65
      UniProtKB/TrEMBL
      F6Q0M4
    2. XM_054328611.1XP_054184586.1  tumor necrosis factor receptor superfamily member 14 isoform X1

      UniProtKB/Swiss-Prot
      B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65
      UniProtKB/TrEMBL
      F6Q0M4
    3. XM_054328610.1XP_054184585.1  tumor necrosis factor receptor superfamily member 14 isoform X1

      UniProtKB/Swiss-Prot
      B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65
      UniProtKB/TrEMBL
      F6Q0M4
    4. XM_054328618.1XP_054184593.1  tumor necrosis factor receptor superfamily member 14 isoform X4

      UniProtKB/TrEMBL
      B9A034, F6UPZ7
    5. XM_054328612.1XP_054184587.1  tumor necrosis factor receptor superfamily member 14 isoform X1

      UniProtKB/Swiss-Prot
      B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65
      UniProtKB/TrEMBL
      F6Q0M4
    6. XM_054328614.1XP_054184589.1  tumor necrosis factor receptor superfamily member 14 isoform X1

      UniProtKB/Swiss-Prot
      B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65
      UniProtKB/TrEMBL
      F6Q0M4
    7. XM_054328616.1XP_054184591.1  tumor necrosis factor receptor superfamily member 14 isoform X3

      UniProtKB/TrEMBL
      F6UPZ7
    8. XM_054328617.1XP_054184592.1  tumor necrosis factor receptor superfamily member 14 isoform X4

      UniProtKB/TrEMBL
      B9A034, F6UPZ7
    9. XM_054328619.1XP_054184594.1  tumor necrosis factor receptor superfamily member 14 isoform X5

      UniProtKB/TrEMBL
      B4DU65, E9PHP3
    10. XM_054328609.1XP_054184584.1  tumor necrosis factor receptor superfamily member 14 isoform X7

    11. XM_054328608.1XP_054184583.1  tumor necrosis factor receptor superfamily member 14 isoform X6

    12. XM_054328615.1XP_054184590.1  tumor necrosis factor receptor superfamily member 14 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      1997007..2005473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339412.1XP_054195387.1  tumor necrosis factor receptor superfamily member 14 isoform X1

      UniProtKB/Swiss-Prot
      B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65
      UniProtKB/TrEMBL
      F6Q0M4
    2. XM_054339410.1XP_054195385.1  tumor necrosis factor receptor superfamily member 14 isoform X1

      UniProtKB/Swiss-Prot
      B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65
      UniProtKB/TrEMBL
      F6Q0M4
    3. XM_054339409.1XP_054195384.1  tumor necrosis factor receptor superfamily member 14 isoform X1

      UniProtKB/Swiss-Prot
      B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65
      UniProtKB/TrEMBL
      F6Q0M4
    4. XM_054339417.1XP_054195392.1  tumor necrosis factor receptor superfamily member 14 isoform X4

      UniProtKB/TrEMBL
      B9A034, F6UPZ7
    5. XM_054339411.1XP_054195386.1  tumor necrosis factor receptor superfamily member 14 isoform X1

      UniProtKB/Swiss-Prot
      B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65
      UniProtKB/TrEMBL
      F6Q0M4
    6. XM_054339413.1XP_054195388.1  tumor necrosis factor receptor superfamily member 14 isoform X1

      UniProtKB/Swiss-Prot
      B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65
      UniProtKB/TrEMBL
      F6Q0M4
    7. XM_054339415.1XP_054195390.1  tumor necrosis factor receptor superfamily member 14 isoform X3

      UniProtKB/TrEMBL
      F6UPZ7
    8. XM_054339416.1XP_054195391.1  tumor necrosis factor receptor superfamily member 14 isoform X4

      UniProtKB/TrEMBL
      B9A034, F6UPZ7
    9. XM_054339418.1XP_054195393.1  tumor necrosis factor receptor superfamily member 14 isoform X5

      UniProtKB/TrEMBL
      B4DU65, E9PHP3
    10. XM_054339408.1XP_054195383.1  tumor necrosis factor receptor superfamily member 14 isoform X9

    11. XM_054339407.1XP_054195382.1  tumor necrosis factor receptor superfamily member 14 isoform X8

    12. XM_054339414.1XP_054195389.1  tumor necrosis factor receptor superfamily member 14 isoform X2