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    RNMT RNA guanine-7 methyltransferase [ Homo sapiens (human) ]

    Gene ID: 8731, updated on 17-Jun-2019

    Summary

    Official Symbol
    RNMTprovided by HGNC
    Official Full Name
    RNA guanine-7 methyltransferaseprovided by HGNC
    Primary source
    HGNC:HGNC:10075
    See related
    Ensembl:ENSG00000101654 MIM:603514
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MET; Met; CMT1; cm1p; hMet; CMT1c; hCMT1; RG7MT1
    Expression
    Ubiquitous expression in brain (RPKM 9.8), thyroid (RPKM 9.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See RNMT in Genome Data Viewer
    Location:
    18p11.21
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (13726645..13764556)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (13726659..13764555)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 4 Neighboring gene microRNA 4526 Neighboring gene family with sequence similarity 210 member A Neighboring gene RNA, 7SL, cytoplasmic 362, pseudogene Neighboring gene melanocortin 5 receptor Neighboring gene melanocortin 2 receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • HIV Infection, organism-specific biosystem (from REACTOME)
      HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
    • HIV Life Cycle, organism-specific biosystem (from REACTOME)
      HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
    • Infectious disease, organism-specific biosystem (from REACTOME)
      Infectious disease, organism-specific biosystem
      Infectious disease
    • Late Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
      Late Phase of HIV Life Cycle, organism-specific biosystemThe late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later relea...
    • RNA Pol II CTD phosphorylation and interaction with CE, organism-specific biosystem (from REACTOME)
      RNA Pol II CTD phosphorylation and interaction with CE, organism-specific biosystemTo facilitate co-transcriptional capping, and thereby restrict the cap structure to RNAs made by RNA polymerase II, the capping enzymes bind directly to the RNA polymerase II. The C-terminal domain ...
    • RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, organism-specific biosystem (from REACTOME)
      RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, organism-specific biosystemTo facilitate co-transcriptional capping, and thereby restrict the cap structure to RNAs made by RNA polymerase II, the capping enzymes bind directly to the RNA polymerase II. The C-terminal domain ...
    • RNA Polymerase II Transcription, organism-specific biosystem (from REACTOME)
      RNA Polymerase II Transcription, organism-specific biosystem
      RNA Polymerase II Transcription
    • Transcription of the HIV genome, organism-specific biosystem (from REACTOME)
      Transcription of the HIV genome, organism-specific biosystemExpression of the integrated HIV-1 provirus is dependent on the host cell Pol II transcription machinery, but is regulated in critical ways by HIV-1 Tat and Rev proteins. The long terminal repeats (L...
    • mRNA Capping, organism-specific biosystem (from REACTOME)
      mRNA Capping, organism-specific biosystemThe 5'-ends of all eukaryotic pre-mRNAs studied thus far are converted to cap structures. The cap is thought to influence splicing of the first intron, and is bound by 'cap-binding' proteins, CBP80 a...
    • mRNA Processing, organism-specific biosystem (from WikiPathways)
      mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
    • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
      mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    • mRNA surveillance pathway, conserved biosystem (from KEGG)
      mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0398, DKFZp686H1252

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA (guanine-N7-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA (guanine-N7-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA (guanine-N7-)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA (guanine-N7-)-methyltransferase activity TAS
    Traceable Author Statement
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    7-methylguanosine mRNA capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    7-methylguanosine mRNA capping IDA
    Inferred from Direct Assay
    more info
    PubMed 
    7-methylguanosine mRNA capping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    7-methylguanosine mRNA capping TAS
    Traceable Author Statement
    more info
     
    RNA 5'-cap (guanine-N7)-methylation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
     
    transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    mRNA cap binding complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA cap binding complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA cap methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mRNA cap guanine-N7 methyltransferase
    Names
    RNA (guanine-7-) methyltransferase
    hcm1p
    mRNA (guanine-7-)methyltransferase
    mRNA (guanine-N(7)-)-methyltransferase
    mRNA cap methyltransferase
    NP_001295192.1
    NP_003790.1
    XP_005258219.1
    XP_011524051.1
    XP_011524052.1
    XP_011524053.1
    XP_011524055.1
    XP_016881550.1
    XP_024307048.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308263.2NP_001295192.1  mRNA cap guanine-N7 methyltransferase isoform 1

      See identical proteins and their annotated locations for NP_001295192.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AB022605, AK292561, AP001525, DA634865
      Consensus CDS
      CCDS77156.1
      UniProtKB/Swiss-Prot
      O43148
      UniProtKB/TrEMBL
      A8K946
      Related
      ENSP00000466111.1, ENST00000592764.5
      Conserved Domains (2) summary
      COG0500
      Location:196414
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam03291
      Location:136466
      Pox_MCEL; mRNA capping enzyme
    2. NM_003799.3NP_003790.1  mRNA cap guanine-N7 methyltransferase isoform 2

      See identical proteins and their annotated locations for NP_003790.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 3' terminal exon, and differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AB022605, AF067791, AP001525, DA634865
      Consensus CDS
      CCDS11867.1
      UniProtKB/Swiss-Prot
      O43148
      Related
      ENSP00000372804.2, ENST00000383314.6
      Conserved Domains (1) summary
      pfam03291
      Location:136475
      Pox_MCEL; mRNA capping enzyme

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

      Range
      13726645..13764556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451280.1XP_024307048.1  mRNA cap guanine-N7 methyltransferase isoform X5

      Related
      ENSP00000467171.1, ENST00000588457.5
      Conserved Domains (1) summary
      cl17173
      Location:1297
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_011525753.2XP_011524055.1  mRNA cap guanine-N7 methyltransferase isoform X4

      Conserved Domains (2) summary
      COG0500
      Location:18149
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      cl17173
      Location:1290
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. XM_005258162.1XP_005258219.1  mRNA cap guanine-N7 methyltransferase isoform X3

      See identical proteins and their annotated locations for XP_005258219.1

      UniProtKB/Swiss-Prot
      O43148
      Related
      ENSP00000446426.1, ENST00000543302.6
      Conserved Domains (1) summary
      pfam03291
      Location:136475
      Pox_MCEL; mRNA capping enzyme
    4. XM_017026061.1XP_016881550.1  mRNA cap guanine-N7 methyltransferase isoform X2

      UniProtKB/Swiss-Prot
      O43148
      Conserved Domains (2) summary
      COG0500
      Location:196414
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam03291
      Location:136466
      Pox_MCEL; mRNA capping enzyme
    5. XM_011525751.1XP_011524053.1  mRNA cap guanine-N7 methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_011524053.1

      Conserved Domains (2) summary
      COG0500
      Location:196414
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam03291
      Location:136468
      Pox_MCEL; mRNA capping enzyme
    6. XM_011525749.2XP_011524051.1  mRNA cap guanine-N7 methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_011524051.1

      Conserved Domains (2) summary
      COG0500
      Location:196414
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam03291
      Location:136468
      Pox_MCEL; mRNA capping enzyme
    7. XM_011525750.2XP_011524052.1  mRNA cap guanine-N7 methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_011524052.1

      Conserved Domains (2) summary
      COG0500
      Location:196414
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam03291
      Location:136468
      Pox_MCEL; mRNA capping enzyme

    RNA

    1. XR_001753297.1 RNA Sequence

    2. XR_001753296.2 RNA Sequence

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