Format

Send to:

Choose Destination
    • Showing Current items.

    GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 [ Homo sapiens (human) ]

    Gene ID: 8693, updated on 6-Sep-2021

    Summary

    Official Symbol
    GALNT4provided by HGNC
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 4provided by HGNC
    Primary source
    HGNC:HGNC:4126
    See related
    Ensembl:ENSG00000257594 MIM:603565
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GALNACT4; GALNAC-T4
    Summary
    This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. In vitro, the encoded protein can complement other GalNAc-Ts in the complete O-glycosylation of the mucin-1 tandem repeat and can O-glycosylate the P-selectin glycoprotein ligand-1 molecule. The coding region of this gene is contained within a single exon. Fusion transcripts, which combine part of this gene with the 5' exons of the neighboring POC1B (POC1 centriolar protein homolog B) gene, also exist. [provided by RefSeq, Dec 2010]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GALNT4 in Genome Data Viewer
    Location:
    12q21.33
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (89519412..89524796, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (89913189..89918573, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 6 Neighboring gene POC1 centriolar protein B Neighboring gene POC1B-GALNT4 readthrough Neighboring gene centromere protein C pseudogene 1 Neighboring gene POC1B antisense RNA 1 Neighboring gene ATPase plasma membrane Ca2+ transporting 1 Neighboring gene ATP2B1 antisense RNA 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough POC1B-GALNT4

    Readthrough gene: POC1B-GALNT4, Included gene: POC1B

    Homology

    Clone Names

    • FLJ93314

    General protein information

    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase 4
    Names
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
    polypeptide GalNAc transferase 4
    pp-GaNTase 4
    protein-UDP acetylgalactosaminyltransferase 4
    NP_003765.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050753.1 RefSeqGene

      Range
      5011..10395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003774.5NP_003765.2  polypeptide N-acetylgalactosaminyltransferase 4

      See identical proteins and their annotated locations for NP_003765.2

      Status: REVIEWED

      Source sequence(s)
      BC036390, CR739813, DA109687
      Consensus CDS
      CCDS53817.1
      UniProtKB/Swiss-Prot
      Q8N4A0
      Related
      ENSP00000436604.2, ENST00000529983.3
      Conserved Domains (2) summary
      cd02510
      Location:138432
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:446574
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      89519412..89524796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center