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    KRT38 keratin 38 [ Homo sapiens (human) ]

    Gene ID: 8687, updated on 7-Apr-2024

    Summary

    Official Symbol
    KRT38provided by HGNC
    Official Full Name
    keratin 38provided by HGNC
    Primary source
    HGNC:HGNC:6456
    See related
    Ensembl:ENSG00000171360 MIM:604542; AllianceGenome:HGNC:6456
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HA8; hHa8; KRTHA8
    Summary
    The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See KRT38 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (41436154..41440983, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (42291709..42296538, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39592406..39597235, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100505782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39567789-39568290 Neighboring gene keratin 41, pseudogene Neighboring gene Sharpr-MPRA regulatory region 10866 Neighboring gene keratin 37 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39596891-39597391 Neighboring gene keratin 43, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39615943-39616444 Neighboring gene keratin 32

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    keratin, type I cuticular Ha8
    Names
    K38
    hair keratin, type I Ha8
    keratin 38, type I
    keratin, hair, acidic, 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012295.1 RefSeqGene

      Range
      5362..10191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006771.4NP_006762.3  keratin, type I cuticular Ha8

      See identical proteins and their annotated locations for NP_006762.3

      Status: VALIDATED

      Source sequence(s)
      AC019349, BC131715
      Consensus CDS
      CCDS11392.1
      UniProtKB/Swiss-Prot
      A2RRM5, O76015, Q6A164
      UniProtKB/TrEMBL
      Q6A165
      Related
      ENSP00000246646.3, ENST00000246646.4
      Conserved Domains (2) summary
      pfam00038
      Location:104414
      Filament; Intermediate filament protein
      pfam08286
      Location:204273
      Spc24; Spc24 subunit of Ndc80

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      41436154..41440983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      42291709..42296538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)