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    MARCO macrophage receptor with collagenous structure [ Homo sapiens (human) ]

    Gene ID: 8685, updated on 15-Jun-2019

    Summary

    Official Symbol
    MARCOprovided by HGNC
    Official Full Name
    macrophage receptor with collagenous structureprovided by HGNC
    Primary source
    HGNC:HGNC:6895
    See related
    Ensembl:ENSG00000019169 MIM:604870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SR-A6; SCARA2
    Summary
    The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in lung (RPKM 74.5), appendix (RPKM 41.8) and 3 other tissues See more
    Orthologs

    Genomic context

    See MARCO in Genome Data Viewer
    Location:
    2q14.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (118942169..118994664)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (119699745..119752236)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927709 Neighboring gene engrailed homeobox 1 Neighboring gene RNA, 7SL, cytoplasmic 468, pseudogene Neighboring gene complement C1q like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr potentiates the stimulation of macrophage receptor with collagenous structure by glucocorticoids via the glucocorticoid receptor pathway PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem (from REACTOME)
      Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystemScavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). So...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Scavenging by Class A Receptors, organism-specific biosystem (from REACTOME)
      Scavenging by Class A Receptors, organism-specific biosystemClass A scavenger receptors contain an intracellular domain, a transmembrane region, a coiled-coil domain, a collagenous domain, and the SR cysteine-rich domain (reviewed in Areschoug and Gordon 2009...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G protein-coupled receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    G protein-coupled receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    amyloid-beta binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cargo receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    signaling pattern recognition receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transmembrane signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    amyloid-beta clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    apoptotic cell clearance IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    pattern recognition receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    phagocytosis, engulfment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    receptor-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    receptor-mediated endocytosis TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    collagen trimer IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    macrophage receptor MARCO
    Names
    scavenger receptor class A, member 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006770.3NP_006761.1  macrophage receptor MARCO

      See identical proteins and their annotated locations for NP_006761.1

      Status: REVIEWED

      Source sequence(s)
      AF035819, BC016004, CB529479
      Consensus CDS
      CCDS2124.1
      UniProtKB/Swiss-Prot
      Q9UEW3
      UniProtKB/TrEMBL
      Q4ZG40
      Related
      ENSP00000318916.4, ENST00000327097.4
      Conserved Domains (2) summary
      pfam01391
      Location:286344
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:424519
      SR; Scavenger receptor Cys-rich

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      118942169..118994664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512082.2XP_011510384.1  macrophage receptor MARCO isoform X1

      See identical proteins and their annotated locations for XP_011510384.1

      UniProtKB/Swiss-Prot
      Q9UEW3
      UniProtKB/TrEMBL
      Q4ZG40
      Conserved Domains (2) summary
      pfam01391
      Location:286344
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:424519
      SR; Scavenger receptor Cys-rich
    2. XM_017005171.2XP_016860660.1  macrophage receptor MARCO isoform X3

    3. XM_011512083.3XP_011510385.1  macrophage receptor MARCO isoform X2

      Conserved Domains (3) summary
      pfam01391
      Location:165223
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:303398
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:308398
      SRCR; Scavenger receptor cysteine-rich domain
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