U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    KMO kynurenine 3-monooxygenase [ Homo sapiens (human) ]

    Gene ID: 8564, updated on 7-Apr-2024

    Summary

    Official Symbol
    KMOprovided by HGNC
    Official Full Name
    kynurenine 3-monooxygenaseprovided by HGNC
    Primary source
    HGNC:HGNC:6381
    See related
    Ensembl:ENSG00000117009 MIM:603538; AllianceGenome:HGNC:6381
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    dJ317G22.1
    Summary
    This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011]
    Expression
    Broad expression in liver (RPKM 11.5), kidney (RPKM 9.8) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KMO in Genome Data Viewer
    Location:
    1q43
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (241532378..241595642)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (240943769..241007043)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (241695678..241758944)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904601 Neighboring gene NANOG hESC enhancer GRCh37_chr1:241581573-241582074 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:241602586-241603173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2007 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:241682833-241683429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2828 Neighboring gene fumarate hydratase Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:241802798-241803368 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:241803369-241803938 Neighboring gene opsin 3 Neighboring gene uncharacterized LOC124904603 Neighboring gene CHM like Rab escort protein Neighboring gene WD repeat domain 64

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables FAD binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD(P)H oxidase H2O2-forming activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables flavin adenine dinucleotide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kynurenine 3-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables kynurenine 3-monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kynurenine 3-monooxygenase activity TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    kynurenine 3-monooxygenase
    Names
    kynurenine 3-hydroxylase
    NP_001397873.1
    NP_003670.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410944.1NP_001397873.1  kynurenine 3-monooxygenase isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL133390, FO393423
      Consensus CDS
      CCDS91182.1
      Related
      ENSP00000355516.3, ENST00000366558.7
    2. NM_003679.5NP_003670.2  kynurenine 3-monooxygenase isoform 1

      See identical proteins and their annotated locations for NP_003670.2

      Status: REVIEWED

      Source sequence(s)
      AF056032, AI262990, AK291558, AL133390, AU137977, CB989076, DB373228, Y13153
      Consensus CDS
      CCDS1618.1
      UniProtKB/Swiss-Prot
      A2A2U8, A2A2U9, A2A2V0, O15229, Q5SY07, Q5SY08, Q5SY09
      UniProtKB/TrEMBL
      A8K693
      Related
      ENSP00000355517.4, ENST00000366559.9
      Conserved Domains (2) summary
      COG0654
      Location:8361
      UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
      cl21454
      Location:11330
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      241532378..241595642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      240943769..241007043
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)