Format

Send to:

Choose Destination
    • Showing Current items.

    GALP galanin like peptide [ Homo sapiens (human) ]

    Gene ID: 85569, updated on 21-Dec-2019

    Summary

    Official Symbol
    GALPprovided by HGNC
    Official Full Name
    galanin like peptideprovided by HGNC
    Primary source
    HGNC:HGNC:24840
    See related
    Ensembl:ENSG00000197487 MIM:611178
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, has vasoactive properties, displays antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumors.[provided by RefSeq, Nov 2014]
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See GALP in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (56176008..56185775)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56687389..56697144)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 787 Neighboring gene Sharpr-MPRA regulatory region 1998 Neighboring gene zinc finger protein 444 Neighboring gene CRISPRi-validated cis-regulatory element chr19.6329 Neighboring gene zinc finger and SCAN domain containing 5B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    behavioral response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    biological_process ND
    No biological Data available
    more info
     
    defense response to Gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of appetite IEA
    Inferred from Electronic Annotation
    more info
     
    response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    galanin-like peptide
    Names
    alarin
    gal-like peptide

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029931.2 RefSeqGene

      Range
      4989..14756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001145546.1NP_001139018.1  galanin-like peptide isoform 2 precursor

      See identical proteins and their annotated locations for NP_001139018.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus compared to isoform 1. This variant, termed alarin, is a candidate for nonsense-mediated mRNA decay (NMD) but is being represented as protein-coding based on evidence supporting the transcript and protein described in PMID 16954604. The exon structure of this variant is based on Figure 1 from PMID 16954604.
      Source sequence(s)
      AC024580, AF188493
      Consensus CDS
      CCDS46202.1
      UniProtKB/Swiss-Prot
      Q9UBC7
      Related
      ENSP00000411521.1, ENST00000440823.1
    2. NM_033106.4NP_149097.1  galanin-like peptide isoform 1 precursor

      See identical proteins and their annotated locations for NP_149097.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC024580, AF188493
      Consensus CDS
      CCDS12940.1
      UniProtKB/Swiss-Prot
      Q9UBC7
      Related
      ENSP00000349884.2, ENST00000357330.7
      Conserved Domains (1) summary
      pfam01296
      Location:3345
      Galanin; Galanin

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      56176008..56185775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center