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    CDC14A cell division cycle 14A [ Homo sapiens (human) ]

    Gene ID: 8556, updated on 15-Jun-2019

    Summary

    Official Symbol
    CDC14Aprovided by HGNC
    Official Full Name
    cell division cycle 14Aprovided by HGNC
    Primary source
    HGNC:HGNC:1718
    See related
    Ensembl:ENSG00000079335 MIM:603504
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    cdc14; DFNB32; DFNB35; hCDC14; DFNB105
    Summary
    The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 5.6), bone marrow (RPKM 3.3) and 24 other tissues See more
    Orthologs

    Genomic context

    See CDC14A in Genome Data Viewer
    Location:
    1p21.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (100345001..100520281)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (100810598..100985833)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA 3'-terminal phosphate cyclase Neighboring gene microRNA 553 Neighboring gene chromosome 5 open reading frame 15 pseudogene Neighboring gene uncharacterized LOC105379827 Neighboring gene BCAS2 pseudogene 2 Neighboring gene G protein-coupled receptor 88 Neighboring gene HNF4 motif-containing MPRA enhancer 127

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
      APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemThe Anaphase Promoting Complex or Cyclosome (APC/C) functions during mitosis to promote sister chromatid separation and mitotic exit through the degradation of mitotic cyclins and securin. This compl...
    • Cell Cycle, organism-specific biosystem (from WikiPathways)
      Cell Cycle, organism-specific biosystemThe cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a c...
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, organism-specific biosystem (from REACTOME)
      Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, organism-specific biosystemThe activity of the APC/C must be appropriately regulated during the cell cycle to ensure the timely degradation of its substrates. Of particular importance is the conversion from APC/C:Cdc20 to APC...
    • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
      MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
    • MAPK6/MAPK4 signaling, organism-specific biosystem (from REACTOME)
      MAPK6/MAPK4 signaling, organism-specific biosystemMAPK6 and MAPK4 (also known as ERK3 and ERK4) are vertebrate-specific atypical MAP kinases. Atypical MAPK are less well characterized than their conventional counterparts, and are generally classifi...
    • Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
      Regulation of mitotic cell cycle, organism-specific biosystem
      Regulation of mitotic cell cycle
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine phosphatase activity TAS
    Traceable Author Statement
    more info
     
    protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic cell cycle arrest IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-tyrosine dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of exit from mitosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    kinociliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kinociliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    kinocilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear body IDA
    Inferred from Direct Assay
    more info
     
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    stereocilium tip ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    dual specificity protein phosphatase CDC14A
    Names
    CDC10 (cell division cycle 10, S. cerevisiae, homolog)
    CDC14 cell division cycle 14 homolog A
    NP_001306139.1
    NP_001306140.1
    NP_001306141.1
    NP_003663.2
    NP_201569.1
    NP_201570.1
    XP_005271351.1
    XP_005271353.1
    XP_011540642.1
    XP_011540643.1
    XP_011540647.1
    XP_016858135.1
    XP_016858136.1
    XP_024306271.1
    XP_024306272.1
    XP_024306273.1
    XP_024306274.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051602.2 RefSeqGene

      Range
      12506..180277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001319210.2NP_001306139.1  dual specificity protein phosphatase CDC14A isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 2.
      Source sequence(s)
      AC104457, AL589990
      Consensus CDS
      CCDS86000.1
      UniProtKB/Swiss-Prot
      Q9UNH5
      Related
      ENSP00000496374.1, ENST00000644813.1
      Conserved Domains (3) summary
      COG2453
      Location:175329
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:17152
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:187326
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. NM_001319211.1NP_001306140.1  dual specificity protein phosphatase CDC14A isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (5) is shorter at the N-terminus compared to isoform 2.
      Source sequence(s)
      AA929031, AF064102, AK302310, DB029799
      Consensus CDS
      CCDS81353.1
      UniProtKB/Swiss-Prot
      Q9UNH5
      UniProtKB/TrEMBL
      A0A0U1RQX7, B4DY86
      Related
      ENSP00000489217.1, ENST00000635056.2
      Conserved Domains (4) summary
      COG2453
      Location:117271
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:194
      DSPn; Dual specificity protein phosphatase, N-terminal half
      pfam15279
      Location:355555
      SOBP; Sine oculis-binding protein
      cl21483
      Location:129268
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    3. NM_001319212.1NP_001306141.1  dual specificity protein phosphatase CDC14A isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate exon compared to variant 2. The resulting isoform (6) is shorter at the C-terminus compared to isoform 2.
      Source sequence(s)
      AA929031, AC104457, AL589990, BC038979, DA461435
      UniProtKB/Swiss-Prot
      Q9UNH5
    4. NM_003672.4NP_003663.2  dual specificity protein phosphatase CDC14A isoform 1

      See identical proteins and their annotated locations for NP_003663.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (1) has a shorter and distinct C-terminus compared to isoform 2.
      Source sequence(s)
      AC104457, AL589990
      Consensus CDS
      CCDS769.1
      UniProtKB/Swiss-Prot
      Q9UNH5
      UniProtKB/TrEMBL
      Q59EF4
      Related
      ENSP00000336739.3, ENST00000336454.5
      Conserved Domains (3) summary
      COG2453
      Location:175329
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:17152
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:187326
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    5. NM_033312.2NP_201569.1  dual specificity protein phosphatase CDC14A isoform 2

      See identical proteins and their annotated locations for NP_201569.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      AA929031, AF122013, BC038979, DA461435, DA885382
      Consensus CDS
      CCDS770.1
      UniProtKB/Swiss-Prot
      Q9UNH5
      Related
      ENSP00000354916.6, ENST00000361544.11
      Conserved Domains (4) summary
      COG2453
      Location:175329
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:17152
      DSPn; Dual specificity protein phosphatase, N-terminal half
      pfam15279
      Location:413613
      SOBP; Sine oculis-binding protein
      cl21483
      Location:187326
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    6. NM_033313.2NP_201570.1  dual specificity protein phosphatase CDC14A isoform 3

      See identical proteins and their annotated locations for NP_201570.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 2.
      Source sequence(s)
      AF064103, AF122013, AL589990, BU609013, CB156695, DA461435, DA885382
      Consensus CDS
      CCDS771.1
      UniProtKB/Swiss-Prot
      Q9UNH5
      Related
      ENSP00000359142.3, ENST00000370124.8
      Conserved Domains (2) summary
      pfam14671
      Location:16152
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:187326
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      100345001..100520281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450503.1XP_024306271.1  dual specificity protein phosphatase CDC14A isoform X5

      Related
      ENSP00000495617.1, ENST00000647005.1
      Conserved Domains (2) summary
      pfam14671
      Location:194
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:129268
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. XM_024450504.1XP_024306272.1  dual specificity protein phosphatase CDC14A isoform X9

    3. XM_017002646.1XP_016858135.1  dual specificity protein phosphatase CDC14A isoform X7

    4. XM_005271294.3XP_005271351.1  dual specificity protein phosphatase CDC14A isoform X1

      Related
      ENSP00000494661.1, ENST00000644676.1
      Conserved Domains (4) summary
      COG2453
      Location:176330
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:18153
      DSPn; Dual specificity protein phosphatase, N-terminal half
      pfam15279
      Location:414614
      SOBP; Sine oculis-binding protein
      cl21483
      Location:188327
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    5. XM_011542340.2XP_011540642.1  dual specificity protein phosphatase CDC14A isoform X3

      Conserved Domains (3) summary
      COG2453
      Location:176330
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:18153
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:188327
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    6. XM_005271296.3XP_005271353.1  dual specificity protein phosphatase CDC14A isoform X4

      Conserved Domains (3) summary
      COG2453
      Location:176330
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:18153
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:188327
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    7. XM_017002647.1XP_016858136.1  dual specificity protein phosphatase CDC14A isoform X8

    8. XM_011542341.3XP_011540643.1  dual specificity protein phosphatase CDC14A isoform X2

      Conserved Domains (4) summary
      COG2453
      Location:163317
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:35140
      DSPn; Dual specificity protein phosphatase, N-terminal half
      pfam15279
      Location:413601
      SOBP; Sine oculis-binding protein
      cl21483
      Location:175314
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    9. XM_024450505.1XP_024306273.1  dual specificity protein phosphatase CDC14A isoform X9

    10. XM_011542345.3XP_011540647.1  dual specificity protein phosphatase CDC14A isoform X6

      Conserved Domains (4) summary
      COG2453
      Location:47201
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:324
      DSPn; Dual specificity protein phosphatase, N-terminal half
      pfam15279
      Location:297485
      SOBP; Sine oculis-binding protein
      cl21483
      Location:59198
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    11. XM_024450506.1XP_024306274.1  dual specificity protein phosphatase CDC14A isoform X9

    RNA

    1. XR_002957888.1 RNA Sequence

    2. XR_002957887.1 RNA Sequence

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