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    MAPKAPK5 MAPK activated protein kinase 5 [ Homo sapiens (human) ]

    Gene ID: 8550, updated on 5-Sep-2021

    Summary

    Official Symbol
    MAPKAPK5provided by HGNC
    Official Full Name
    MAPK activated protein kinase 5provided by HGNC
    Primary source
    HGNC:HGNC:6889
    See related
    Ensembl:ENSG00000089022 MIM:606723
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MK5; MK-5; PRAK; MAPKAP-K5
    Summary
    The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]
    Expression
    Ubiquitous expression in small intestine (RPKM 3.1), colon (RPKM 2.9) and 25 other tissues See more
    Orthologs
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    Genomic context

    See MAPKAPK5 in Genome Data Viewer
    Location:
    12q24.12-q24.13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (111842228..111902222)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (112280032..112340026)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene acyl-CoA dehydrogenase family member 10 Neighboring gene aldehyde dehydrogenase 2 family member Neighboring gene microRNA 6761 Neighboring gene MAPKAPK5 antisense RNA 1 Neighboring gene ribosomal protein S2 pseudogene 41 Neighboring gene transmembrane protein 116 Neighboring gene ADAM metallopeptidase domain 1A (pseudogene) Neighboring gene ADAM metallopeptidase domain 1B (pseudogene) Neighboring gene solute carrier family 25 member 3 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables calcium-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mitogen-activated protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables p53 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in Ras protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular senescence TAS
    Traceable Author Statement
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of telomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of telomere capping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of signal transduction by p53 class mediator TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in stress-induced premature senescence IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    MAP kinase-activated protein kinase 5
    Names
    MAPKAP kinase 5
    MAPKAPK-5
    mitogen-activated protein kinase-activated protein kinase 5
    p38-regulated/activated protein kinase
    NP_001358408.1
    NP_001358409.1
    NP_001358410.1
    NP_001358411.1
    NP_001358412.1
    NP_001358413.1
    NP_001358414.1
    NP_001358415.1
    NP_001358416.1
    NP_003659.2
    NP_620777.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001371479.1NP_001358408.1  MAP kinase-activated protein kinase 5 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC003029
      Conserved Domains (1) summary
      cd14171
      Location:15304
      STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5
    2. NM_001371480.1NP_001358409.1  MAP kinase-activated protein kinase 5 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC003029
      Conserved Domains (1) summary
      cd14171
      Location:15304
      STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5
    3. NM_001371481.1NP_001358410.1  MAP kinase-activated protein kinase 5 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC003029
      Conserved Domains (1) summary
      cl21453
      Location:15277
      PKc_like; Protein Kinases, catalytic domain
    4. NM_001371482.1NP_001358411.1  MAP kinase-activated protein kinase 5 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC003029
      Conserved Domains (1) summary
      cl21453
      Location:15274
      PKc_like; Protein Kinases, catalytic domain
    5. NM_001371483.1NP_001358412.1  MAP kinase-activated protein kinase 5 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC003029
      Conserved Domains (1) summary
      cl21453
      Location:15274
      PKc_like; Protein Kinases, catalytic domain
    6. NM_001371484.1NP_001358413.1  MAP kinase-activated protein kinase 5 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC003029
      Conserved Domains (1) summary
      cl21453
      Location:15270
      PKc_like; Protein Kinases, catalytic domain
    7. NM_001371485.1NP_001358414.1  MAP kinase-activated protein kinase 5 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC003029
      Conserved Domains (1) summary
      cl21453
      Location:15235
      PKc_like; Protein Kinases, catalytic domain
    8. NM_001371486.1NP_001358415.1  MAP kinase-activated protein kinase 5 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC003029
      Conserved Domains (1) summary
      cl21453
      Location:15235
      PKc_like; Protein Kinases, catalytic domain
    9. NM_001371487.1NP_001358416.1  MAP kinase-activated protein kinase 5 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC003029
      Related
      ENSP00000473467.1, ENST00000549875.1
      Conserved Domains (1) summary
      cl21453
      Location:15205
      PKc_like; Protein Kinases, catalytic domain
    10. NM_003668.4NP_003659.2  MAP kinase-activated protein kinase 5 isoform 1

      See identical proteins and their annotated locations for NP_003659.2

      Status: REVIEWED

      Source sequence(s)
      AC003029
      Consensus CDS
      CCDS44976.1
      UniProtKB/Swiss-Prot
      Q8IW41
      Related
      ENSP00000449667.2, ENST00000550735.7
      Conserved Domains (1) summary
      cd14171
      Location:15304
      STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5
    11. NM_139078.3NP_620777.1  MAP kinase-activated protein kinase 5 isoform 2

      See identical proteins and their annotated locations for NP_620777.1

      Status: REVIEWED

      Source sequence(s)
      AC003029
      Consensus CDS
      CCDS44975.1
      UniProtKB/Swiss-Prot
      Q8IW41
      Related
      ENSP00000449381.2, ENST00000551404.6
      Conserved Domains (1) summary
      cd14171
      Location:15304
      STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      111842228..111902222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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