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    SSH2 slingshot protein phosphatase 2 [ Homo sapiens (human) ]

    Gene ID: 85464, updated on 17-Jun-2019

    Summary

    Official Symbol
    SSH2provided by HGNC
    Official Full Name
    slingshot protein phosphatase 2provided by HGNC
    Primary source
    HGNC:HGNC:30580
    See related
    Ensembl:ENSG00000141298 MIM:606779
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SSH-2; SSH-2L
    Summary
    This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
    Expression
    Broad expression in lymph node (RPKM 6.2), appendix (RPKM 6.0) and 24 other tissues See more
    Orthologs

    Genomic context

    See SSH2 in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (29625938..29930239, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27952956..28257231, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 13B Neighboring gene GIT ArfGAP 1 Neighboring gene uncharacterized LOC107984990 Neighboring gene RNA, U6 small nuclear 920, pseudogene Neighboring gene coronin 6 Neighboring gene VISTA enhancer hs1675 Neighboring gene ribosomal protein L21 pseudogene 123 Neighboring gene RNA terminal phosphate cyclase like 1 pseudogene Neighboring gene ribosomal protein L9 pseudogene 30 Neighboring gene EF-hand calcium binding domain 5 Neighboring gene RNY4 pseudogene 13 Neighboring gene syntaxin 18 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
    NHGRI GWA Catalog

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1725, MGC78588

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-tyrosine dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space HDA PubMed 

    General protein information

    Preferred Names
    protein phosphatase Slingshot homolog 2
    Names
    SSH-like protein 2
    NP_001269058.1
    NP_001269059.1
    NP_001269060.1
    NP_203747.2
    XP_005258115.1
    XP_005258116.1
    XP_005258117.1
    XP_006722212.1
    XP_011523704.1
    XP_011523706.1
    XP_011523707.1
    XP_011523708.1
    XP_011523709.1
    XP_016880740.1
    XP_016880741.1
    XP_016880742.1
    XP_016880743.1
    XP_016880744.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282129.2NP_001269058.1  protein phosphatase Slingshot homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_001269058.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB099290, AC104982, AI609950, AK296413, DA749059
      Consensus CDS
      CCDS74024.1
      UniProtKB/Swiss-Prot
      Q76I76
      UniProtKB/TrEMBL
      B4DK64, F5H527
      Related
      ENSP00000444743.1, ENST00000540801.6
      Conserved Domains (3) summary
      cd11652
      Location:38263
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:335470
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:278329
      DEK_C; DEK C terminal domain
    2. NM_001282130.2NP_001269059.1  protein phosphatase Slingshot homolog 2 isoform 3

      See identical proteins and their annotated locations for NP_001269059.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks multiple coding exons and contains an alternate 3' exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC104564, AC104982, BC008941, DA749059
      UniProtKB/Swiss-Prot
      Q76I76
      Conserved Domains (1) summary
      cd11652
      Location:3178
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    3. NM_001282131.2NP_001269060.1  protein phosphatase Slingshot homolog 2 isoform 4

      See identical proteins and their annotated locations for NP_001269060.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains multiple differences in the UTRs and coding region, compared to variant 1, including the lack of multiple 5' and 3' coding exons. It represents use of an internal promoter and initiates translation at an alternate start codon. The encoded isoform (4) is shorter and has distinct N- and C- termini, compared to isoform 1.
      Source sequence(s)
      AC104564, BC008941, BC011636, DA861985
      UniProtKB/Swiss-Prot
      Q76I76
      Related
      ENSP00000497894.1, ENST00000324677.12
      Conserved Domains (1) summary
      cd11652
      Location:37185
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    4. NM_033389.3NP_203747.2  protein phosphatase Slingshot homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_203747.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB099290, AC104564, AI609950, DA749059
      Consensus CDS
      CCDS11253.1
      UniProtKB/Swiss-Prot
      Q76I76
      Related
      ENSP00000269033.3, ENST00000269033.7
      Conserved Domains (3) summary
      cd11652
      Location:3236
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:308443
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:251302
      DEK_C; DEK C terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      29625938..29930239 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005258058.3XP_005258115.1  protein phosphatase Slingshot homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_005258115.1

      UniProtKB/TrEMBL
      F5H527
      Conserved Domains (3) summary
      cd11652
      Location:38263
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:335470
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:278329
      DEK_C; DEK C terminal domain
    2. XM_017025252.1XP_016880741.1  protein phosphatase Slingshot homolog 2 isoform X9

    3. XM_017025251.2XP_016880740.1  protein phosphatase Slingshot homolog 2 isoform X2

    4. XM_011525402.2XP_011523704.1  protein phosphatase Slingshot homolog 2 isoform X3

      Conserved Domains (3) summary
      cd11652
      Location:18243
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:315450
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:258309
      DEK_C; DEK C terminal domain
    5. XM_011525407.1XP_011523709.1  protein phosphatase Slingshot homolog 2 isoform X8

      See identical proteins and their annotated locations for XP_011523709.1

      Conserved Domains (3) summary
      cd11652
      Location:17160
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:232367
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:175226
      DEK_C; DEK C terminal domain
    6. XM_011525406.2XP_011523708.1  protein phosphatase Slingshot homolog 2 isoform X8

      See identical proteins and their annotated locations for XP_011523708.1

      Conserved Domains (3) summary
      cd11652
      Location:17160
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:232367
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:175226
      DEK_C; DEK C terminal domain
    7. XM_011525405.2XP_011523707.1  protein phosphatase Slingshot homolog 2 isoform X7

      Conserved Domains (3) summary
      cd11652
      Location:8207
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:279414
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:222273
      DEK_C; DEK C terminal domain
    8. XM_006722149.4XP_006722212.1  protein phosphatase Slingshot homolog 2 isoform X6

      Conserved Domains (3) summary
      cd11652
      Location:14214
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:286421
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:229280
      DEK_C; DEK C terminal domain
    9. XM_011525404.2XP_011523706.1  protein phosphatase Slingshot homolog 2 isoform X5

      Conserved Domains (3) summary
      cd11652
      Location:18218
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:290425
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:233284
      DEK_C; DEK C terminal domain
    10. XM_005258060.3XP_005258117.1  protein phosphatase Slingshot homolog 2 isoform X10

    11. XM_005258059.2XP_005258116.1  protein phosphatase Slingshot homolog 2 isoform X4

      See identical proteins and their annotated locations for XP_005258116.1

      Related
      ENSP00000497148.1, ENST00000649863.1
      Conserved Domains (3) summary
      cd11652
      Location:37243
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:315450
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:258309
      DEK_C; DEK C terminal domain
    12. XM_017025254.2XP_016880743.1  protein phosphatase Slingshot homolog 2 isoform X12

    13. XM_017025253.2XP_016880742.1  protein phosphatase Slingshot homolog 2 isoform X11

    14. XM_017025255.2XP_016880744.1  protein phosphatase Slingshot homolog 2 isoform X13

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