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    CAMK1 calcium/calmodulin dependent protein kinase I [ Homo sapiens (human) ]

    Gene ID: 8536, updated on 17-Jun-2019

    Summary

    Official Symbol
    CAMK1provided by HGNC
    Official Full Name
    calcium/calmodulin dependent protein kinase Iprovided by HGNC
    Primary source
    HGNC:HGNC:1459
    See related
    Ensembl:ENSG00000134072 MIM:604998
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAMKI
    Summary
    Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in adrenal (RPKM 42.3), fat (RPKM 25.3) and 22 other tissues See more
    Orthologs

    Genomic context

    See CAMK1 in Genome Data Viewer
    Location:
    3p25.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (9757345..9769987, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9799029..9811676, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene copine family member 9 Neighboring gene bromodomain and PHD finger containing 1 Neighboring gene 8-oxoguanine DNA glycosylase Neighboring gene transcriptional adaptor 3 Neighboring gene ARPC4-TTLL3 readthrough Neighboring gene actin related protein 2/3 complex subunit 4 Neighboring gene tubulin tyrosine ligase like 3 Neighboring gene RNA pseudouridine synthase D3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-induced neuron death is inhibited by CCL3L1 treatment via the phosphorylation of CREB, the upregulation of Bcl-2, and the PKA and CaMKI/CaMKIV cell signaling pathways PubMed
    Tat tat HIV-1 Tat-peptide(48-60) inhibits AGC-family kinases (PKB, SGK1, S6K1, MSK1), CAMK-family kinases (CAMK1 and MELK) and a STE family kinase (MKK1) PubMed
    tat Microarray analysis indicates HIV-1 Tat downregulates the expression of many proteins, including CAMK1, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Aldosterone synthesis and secretion, organism-specific biosystem (from KEGG)
      Aldosterone synthesis and secretion, organism-specific biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
    • Aldosterone synthesis and secretion, conserved biosystem (from KEGG)
      Aldosterone synthesis and secretion, conserved biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
    • Association Between Physico-Chemical Features and Toxicity Associated Pathways, organism-specific biosystem (from WikiPathways)
      Association Between Physico-Chemical Features and Toxicity Associated Pathways, organism-specific biosystemThis pathway is based on Figure 8 of "Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome."(See bibliography). These 3 pathways demonstr...
    • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
      Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
      Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
    • Oxytocin signaling pathway, conserved biosystem (from KEGG)
      Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC120317, MGC120318

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calmodulin-dependent protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of synapse structural plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of syncytium formation by plasma membrane fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT regulation of histone H3-K9 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    calcium/calmodulin-dependent protein kinase type 1
    Names
    caM kinase I alpha
    caM-KI
    caMKI-alpha
    NP_003647.1
    XP_005265573.1
    XP_005265574.1
    XP_016862843.1
    XP_024309564.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003656.5NP_003647.1  calcium/calmodulin-dependent protein kinase type 1

      See identical proteins and their annotated locations for NP_003647.1

      Status: REVIEWED

      Source sequence(s)
      AA724193, BC106754, DN990042
      Consensus CDS
      CCDS2582.1
      UniProtKB/Swiss-Prot
      Q14012
      UniProtKB/TrEMBL
      B0YIY3
      Related
      ENSP00000256460.3, ENST00000256460.8
      Conserved Domains (1) summary
      cd14167
      Location:16278
      STKc_CaMKI_alpha; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      9757345..9769987 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007354.1XP_016862843.1  calcium/calmodulin-dependent protein kinase type 1 isoform X3

      Conserved Domains (2) summary
      smart00220
      Location:8232
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:16234
      PKc_like; Protein Kinases, catalytic domain
    2. XM_005265517.3XP_005265574.1  calcium/calmodulin-dependent protein kinase type 1 isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:8232
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:16231
      PKc_like; Protein Kinases, catalytic domain
    3. XM_024453796.1XP_024309564.1  calcium/calmodulin-dependent protein kinase type 1 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1216
      PKc_like; Protein Kinases, catalytic domain
    4. XM_005265516.2XP_005265573.1  calcium/calmodulin-dependent protein kinase type 1 isoform X1

      Conserved Domains (2) summary
      smart00220
      Location:20276
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14167
      Location:16278
      STKc_CaMKI_alpha; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha

    RNA

    1. XR_940505.2 RNA Sequence

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