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    COPS3 COP9 signalosome subunit 3 [ Homo sapiens (human) ]

    Gene ID: 8533, updated on 8-Aug-2021

    Summary

    Official Symbol
    COPS3provided by HGNC
    Official Full Name
    COP9 signalosome subunit 3provided by HGNC
    Primary source
    HGNC:HGNC:2239
    See related
    Ensembl:ENSG00000141030 MIM:604665
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSN3; SGN3
    Summary
    The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
    Expression
    Ubiquitous expression in testis (RPKM 49.1), bone marrow (RPKM 38.5) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See COPS3 in Genome Data Viewer
    Location:
    17p11.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (17246616..17281303, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (17149930..17184560, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene folliculin Neighboring gene actin gamma 1 pseudogene 24 Neighboring gene 5',3'-nucleotidase, mitochondrial Neighboring gene Sharpr-MPRA regulatory region 4579

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr is identified to have a physical interaction with COP9 constitutive photomorphogenic homolog subunit 3 (COPS3; CSN3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein deneddylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to light stimulus TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    COP9 signalosome complex subunit 3
    Names
    COP9 complex subunit 3
    COP9 constitutive photomorphogenic homolog subunit 3
    JAB1-containing signalosome subunit 3
    signalosome subunit 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199125.1NP_001186054.1  COP9 signalosome complex subunit 3 isoform 2

      See identical proteins and their annotated locations for NP_001186054.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC055811, AK302304, BU952436
      Consensus CDS
      CCDS56022.1
      UniProtKB/Swiss-Prot
      Q9UNS2
      Related
      ENSP00000437606.2, ENST00000539941.6
      Conserved Domains (1) summary
      pfam01399
      Location:239342
      PCI; PCI domain
    2. NM_001316354.2NP_001303283.1  COP9 signalosome complex subunit 3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains two alternate splice junctions compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC055811, AK297706, BC001891, BP260214, BU952436, DB493356
      UniProtKB/Swiss-Prot
      Q9UNS2
      UniProtKB/TrEMBL
      B4DN01
      Conserved Domains (1) summary
      pfam01399
      Location:129232
      PCI; PCI domain
    3. NM_001316355.2NP_001303284.1  COP9 signalosome complex subunit 3 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC055811, AF031647, BC001891, BI520077, BP260214, BU952436, DB493356
      UniProtKB/Swiss-Prot
      Q9UNS2
      Conserved Domains (1) summary
      smart00088
      Location:251325
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    4. NM_001316356.2NP_001303285.1  COP9 signalosome complex subunit 3 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks a 5' exon compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (5) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC055811, AF031647, BC001891, BP260214, BU171304, BU952436, DB493356
      UniProtKB/Swiss-Prot
      Q9UNS2
      Conserved Domains (1) summary
      pfam01399
      Location:192295
      PCI; PCI domain
    5. NM_001316357.2NP_001303286.1  COP9 signalosome complex subunit 3 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate exon compared to variant 1. The resulting isoform (6) has a shorter and distinct N-terminus compared to isoform 1. Variants 6 and 7 both encode the same isoform (6).
      Source sequence(s)
      AC055811, AF031647, BC001891, BU154357, BU952436
      UniProtKB/Swiss-Prot
      Q9UNS2
      Conserved Domains (1) summary
      pfam01399
      Location:154257
      PCI; PCI domain
    6. NM_001316358.2NP_001303287.1  COP9 signalosome complex subunit 3 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two alternate exons compared to variant 1. The resulting isoform (6) has a shorter and distinct N-terminus compared to isoform 1. Variants 6 and 7 both encode the same isoform (6).
      Source sequence(s)
      AC055811, AF031647, BC001891, BG030374, BP260214, BU952436
      UniProtKB/Swiss-Prot
      Q9UNS2
      Conserved Domains (1) summary
      pfam01399
      Location:154257
      PCI; PCI domain
    7. NM_003653.4NP_003644.2  COP9 signalosome complex subunit 3 isoform 1

      See identical proteins and their annotated locations for NP_003644.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC055811, BC001891, BU952436
      Consensus CDS
      CCDS11183.1
      UniProtKB/Swiss-Prot
      Q9UNS2
      Related
      ENSP00000268717.5, ENST00000268717.10
      Conserved Domains (1) summary
      pfam01399
      Location:259362
      PCI; PCI domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      17246616..17281303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005256837.4XP_005256894.1  COP9 signalosome complex subunit 3 isoform X1

      See identical proteins and their annotated locations for XP_005256894.1

      UniProtKB/Swiss-Prot
      Q9UNS2
      Conserved Domains (1) summary
      pfam01399
      Location:239342
      PCI; PCI domain
    2. XM_005256840.3XP_005256897.1  COP9 signalosome complex subunit 3 isoform X3

      See identical proteins and their annotated locations for XP_005256897.1

      Conserved Domains (1) summary
      pfam01399
      Location:129232
      PCI; PCI domain
    3. XM_005256842.4XP_005256899.1  COP9 signalosome complex subunit 3 isoform X3

      See identical proteins and their annotated locations for XP_005256899.1

      Conserved Domains (1) summary
      pfam01399
      Location:129232
      PCI; PCI domain
    4. XM_017025246.1XP_016880735.1  COP9 signalosome complex subunit 3 isoform X2

      Conserved Domains (1) summary
      pfam01399
      Location:154257
      PCI; PCI domain
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