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    HAT1 histone acetyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 8520, updated on 12-Oct-2019

    Summary

    Official Symbol
    HAT1provided by HGNC
    Official Full Name
    histone acetyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:4821
    See related
    Ensembl:ENSG00000128708 MIM:603053
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KAT1
    Summary
    The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]
    Expression
    Ubiquitous expression in lymph node (RPKM 13.0), bone marrow (RPKM 11.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See HAT1 in Genome Data Viewer
    Location:
    2q31.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (171922425..171983686)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (172778935..172848600)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373739 Neighboring gene uncharacterized LOC105373740 Neighboring gene VISTA enhancer hs646 Neighboring gene PDGFA associated protein 1 pseudogene Neighboring gene methionyl aminopeptidase type 1D, mitochondrial Neighboring gene VISTA enhancer hs553 Neighboring gene distal-less homeobox 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120 PubMed
    Vpr vpr HIV-1 Vpr forms a complex by recruiting RbAp46, HAT1, ZIP/sZIP, and Cul4A PubMed
    vpr HIV-1 Vpr is identified to have a physical interaction with histone acetyltransferase 1 (HAT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Alcoholism, organism-specific biosystem (from KEGG)
      Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Alcoholism, conserved biosystem (from KEGG)
      Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
      Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
    • Chromatin organization, organism-specific biosystem (from REACTOME)
      Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
    • HATs acetylate histones, organism-specific biosystem (from REACTOME)
      HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    H4 histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    H4 histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone acetyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA packaging TAS
    Traceable Author Statement
    more info
    PubMed 
    DNA replication-dependent nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA replication-independent nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin silencing at telomere IEA
    Inferred from Electronic Annotation
    more info
     
    histone H4 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone H4 acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    internal protein amino acid acetylation TAS
    Traceable Author Statement
    more info
    PubMed 
    response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromosome, telomeric region HDA PubMed 
    nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone acetyltransferase type B catalytic subunit
    NP_003633.2
    XP_006712871.1
    XP_016860625.1
    XP_016860626.1
    XP_024308954.1
    XP_024308955.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003642.4NP_003633.2  histone acetyltransferase type B catalytic subunit

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
      Source sequence(s)
      AC114745
      Consensus CDS
      CCDS2245.1
      Related
      ENSP00000264108.4, ENST00000264108.5
      Conserved Domains (1) summary
      pfam10394
      Location:25187
      Hat1_N; Histone acetyl transferase HAT1 N-terminus

    RNA

    1. NR_027862.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC063003, DB050336
      Related
      ENST00000412731.5

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      171922425..171983686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006712808.3XP_006712871.1  histone acetyltransferase type B catalytic subunit isoform X1

      See identical proteins and their annotated locations for XP_006712871.1

      Conserved Domains (1) summary
      pfam10394
      Location:19181
      Hat1_N; Histone acetyl transferase HAT1 N-terminus
    2. XM_024453187.1XP_024308955.1  histone acetyltransferase type B catalytic subunit isoform X1

      Conserved Domains (1) summary
      pfam10394
      Location:19181
      Hat1_N; Histone acetyl transferase HAT1 N-terminus
    3. XM_024453186.1XP_024308954.1  histone acetyltransferase type B catalytic subunit isoform X1

      Conserved Domains (1) summary
      pfam10394
      Location:19181
      Hat1_N; Histone acetyl transferase HAT1 N-terminus
    4. XM_017005136.2XP_016860625.1  histone acetyltransferase type B catalytic subunit isoform X1

      Conserved Domains (1) summary
      pfam10394
      Location:19181
      Hat1_N; Histone acetyl transferase HAT1 N-terminus
    5. XM_017005137.2XP_016860626.1  histone acetyltransferase type B catalytic subunit isoform X1

      Conserved Domains (1) summary
      pfam10394
      Location:19181
      Hat1_N; Histone acetyl transferase HAT1 N-terminus

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033085.1: Suppressed sequence

      Description
      NM_001033085.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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