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    PIK3R3 phosphoinositide-3-kinase regulatory subunit 3 [ Homo sapiens (human) ]

    Gene ID: 8503, updated on 19-Sep-2024

    Summary

    Official Symbol
    PIK3R3provided by HGNC
    Official Full Name
    phosphoinositide-3-kinase regulatory subunit 3provided by HGNC
    Primary source
    HGNC:HGNC:8981
    See related
    Ensembl:ENSG00000117461 MIM:606076; AllianceGenome:HGNC:8981
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p55; p55PIK; p55-GAMMA
    Summary
    Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016]
    Expression
    Broad expression in testis (RPKM 19.6), fat (RPKM 8.4) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PIK3R3 in Genome Data Viewer
    Location:
    1p34.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (46040140..46174901, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (45917331..46052095, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46505812..46640573, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microtubule associated serine/threonine kinase 2 Neighboring gene Sharpr-MPRA regulatory region 10352 Neighboring gene uncharacterized LOC105378694 Neighboring gene translation machinery associated 16 homolog pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 5403 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:46392868-46393561 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46406659-46407160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46407161-46407660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 836 Neighboring gene MPRA-validated peak202 silencer Neighboring gene P3R3URF-PIK3R3 readthrough Neighboring gene OCT4 hESC enhancer GRCh37_chr1:46502635-46503136 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:46508718-46509562 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:46509563-46510406 Neighboring gene uncharacterized LOC124904171 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:46527714-46528913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 992 Neighboring gene uncharacterized LOC101929626 Neighboring gene COX7B pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 837 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 838 Neighboring gene PIK3R3 upstream open reading frame Neighboring gene tetraspanin 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:46683827-46684328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46685102-46685602 Neighboring gene protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) Neighboring gene leucine rich adaptor protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough P3R3URF-PIK3R3

    Readthrough gene: P3R3URF-PIK3R3, Included gene: P3R3URF

    Clone Names

    • FLJ41892, DKFZp686P05226

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables 1-phosphatidylinositol-3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphotyrosine residue binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of phosphatidylinositol 3-kinase complex, class IA IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of phosphatidylinositol 3-kinase complex, class IA NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    phosphatidylinositol 3-kinase regulatory subunit gamma
    Names
    PI3-kinase regulatory subunit gamma
    PI3-kinase subunit p55-gamma
    PI3K regulatory subunit gamma
    phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma
    phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 3 (p55, gamma)
    phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
    ptdIns-3-kinase regulatory subunit p55-gamma

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050949.1 RefSeqGene

      Range
      48867..141356
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001114172.1NP_001107644.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

      See identical proteins and their annotated locations for NP_001107644.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK313726, BC021622, U90907
      Consensus CDS
      CCDS529.1
      UniProtKB/Swiss-Prot
      B2R9C1, D3DQ12, O60482, Q5T4P1, Q5T4P2, Q92569
      UniProtKB/TrEMBL
      Q8N381
      Related
      ENSP00000412546.1, ENST00000420542.5
      Conserved Domains (4) summary
      cd09930
      Location:351454
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:59167
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      pfam16454
      Location:171330
      PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
      cl23765
      Location:172332
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    2. NM_001303428.1NP_001290357.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate exon and uses an alternate splice site in the 5' coding region. These differences cause translation initiation at an upstream start codon compared to variant 1. The encoded isoform (3) has a longer N-terminus than isoform 1.
      Source sequence(s)
      AK302049, BX537388, CR749649
      UniProtKB/TrEMBL
      Q7Z3W2
      Conserved Domains (4) summary
      cd09930
      Location:368471
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:76184
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd12925
      Location:189349
      iSH2_PIK3R3; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 3, PIK3R3, also called p55gamma
      pfam16454
      Location:188347
      PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
    3. NM_001303429.2NP_001290358.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 4

      See identical proteins and their annotated locations for NP_001290358.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AF028785, BC021622, BX507484, BX537388, CR749649
      Consensus CDS
      CCDS76154.1
      UniProtKB/TrEMBL
      Q8N381
      Related
      ENSP00000391431.1, ENST00000423209.5
      Conserved Domains (3) summary
      cd09930
      Location:292395
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:59167
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cl25402
      Location:172273
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    4. NM_001328648.1NP_001315577.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1. Variants 6, 7, 8, and 9 all encode the same isoform (5).
      Source sequence(s)
      AL358075, AL672043
      UniProtKB/TrEMBL
      Q8N381
    5. NM_001328649.1NP_001315578.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1. Variants 6, 7, 8, and 9 all encode the same isoform (5).
      Source sequence(s)
      AL358075
      UniProtKB/TrEMBL
      Q8N381
    6. NM_001328650.1NP_001315579.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1. Variants 6, 7, 8, and 9 all encode the same isoform (5).
      Source sequence(s)
      AL358075
      UniProtKB/TrEMBL
      Q8N381
    7. NM_001328651.1NP_001315580.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1. Variants 6, 7, 8, and 9 all encode the same isoform (5).
      Source sequence(s)
      AL358075
      UniProtKB/TrEMBL
      Q8N381
    8. NM_001328652.2NP_001315581.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) lacks an alternate in-frame exon in the 3' end compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL358075
      UniProtKB/TrEMBL
      Q8N381
    9. NM_001328653.2NP_001315582.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) lacks an alternate exon in the 5' end and uses a downstream start codon compared to variant 1. The resulting isoform (7) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL358075
      UniProtKB/TrEMBL
      Q8N381
    10. NM_001328654.2NP_001315583.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) lacks two alternate exons in the 5' end and uses a downstream start codon compared to variant 1. The resulting isoform (8) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL358075
      UniProtKB/TrEMBL
      B4E3G5
    11. NM_003629.4NP_003620.3  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

      See identical proteins and their annotated locations for NP_003620.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC021622, BC094768, U90907
      Consensus CDS
      CCDS529.1
      UniProtKB/Swiss-Prot
      B2R9C1, D3DQ12, O60482, Q5T4P1, Q5T4P2, Q92569
      UniProtKB/TrEMBL
      Q8N381
      Related
      ENSP00000262741.5, ENST00000262741.10
      Conserved Domains (4) summary
      cd09930
      Location:351454
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:59167
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      pfam16454
      Location:171330
      PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
      cl23765
      Location:172332
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RNA

    1. NR_137329.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AL358075

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      46040140..46174901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      45917331..46052095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)