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    TMEM60 transmembrane protein 60 [ Homo sapiens (human) ]

    Gene ID: 85025, updated on 17-Sep-2024

    Summary

    Official Symbol
    TMEM60provided by HGNC
    Official Full Name
    transmembrane protein 60provided by HGNC
    Primary source
    HGNC:HGNC:21754
    See related
    Ensembl:ENSG00000135211 AllianceGenome:HGNC:21754
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DC32; C7orf35
    Summary
    Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 13.9), thyroid (RPKM 12.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TMEM60 in Genome Data Viewer
    Location:
    7q11.23
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (77793728..77798434, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (79045656..79050361, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (77423045..77427751, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375363 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:77305655-77305829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:77321385-77321884 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:77324871-77325766 Neighboring gene Alu-mediated CDKN1A/p21 transcriptional regulator Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:77325767-77326662 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18329 Neighboring gene round spermatid basic protein 1 like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:77393580-77394080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18330 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18331 Neighboring gene putative homeodomain transcription factor 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:77464234-77464734 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:77501601-77502172 Neighboring gene uncharacterized LOC124901682 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:77619182-77620381 Neighboring gene DDX3 interacting lncRNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC74482

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032936.4NP_116325.1  transmembrane protein 60

      See identical proteins and their annotated locations for NP_116325.1

      Status: VALIDATED

      Source sequence(s)
      AC004955, AF260336, BX117806
      Consensus CDS
      CCDS5593.1
      UniProtKB/Swiss-Prot
      A4D1C3, Q86UM0, Q9H2L4
      Related
      ENSP00000257663.3, ENST00000257663.4
      Conserved Domains (1) summary
      pfam10269
      Location:25118
      Tmemb_185A; Transmembrane Fragile-X-F protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      77793728..77798434 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      79045656..79050361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)