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    RIOX2 ribosomal oxygenase 2 [ Homo sapiens (human) ]

    Gene ID: 84864, updated on 17-Jun-2019

    Summary

    Official Symbol
    RIOX2provided by HGNC
    Official Full Name
    ribosomal oxygenase 2provided by HGNC
    Primary source
    HGNC:HGNC:19441
    See related
    Ensembl:ENSG00000170854 MIM:612049
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ROX; MDIG; MINA; NO52; JMJD10; MINA53
    Summary
    MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 23.6), skin (RPKM 10.0) and 24 other tissues See more
    Orthologs

    Genomic context

    See RIOX2 in Genome Data Viewer
    Location:
    3q11.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (97941817..97972451, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (97660661..97691295, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor like GTPase 6 Neighboring gene uncharacterized LOC101929298 Neighboring gene uncharacterized LOC105373994 Neighboring gene crystallin beta-gamma domain containing 3 Neighboring gene gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene) Neighboring gene Sharpr-MPRA regulatory region 13337

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
      Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
    • Chromatin organization, organism-specific biosystem (from REACTOME)
      Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
    • HDMs demethylate histones, organism-specific biosystem (from REACTOME)
      HDMs demethylate histones, organism-specific biosystemHistone lysine demethylases (KDMs) are able to reverse N-methylations of histones and probably other proteins. To date KDMs have been demonstrated to catalyse demethylation of N-epsilon methylated ly...
    • Validated targets of C-MYC transcriptional activation, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional activation, organism-specific biosystem
      Validated targets of C-MYC transcriptional activation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ14393, DKFZp762O1912

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    negative regulation of nucleic acid-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ribosomal oxygenase 2
    Names
    60S ribosomal protein L27a histidine hydroxylase
    MYC induced nuclear antigen
    bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA
    histone lysine demethylase MINA
    mineral dust induced gene protein
    myc-induced nuclear antigen, 53 kDa
    nucleolar protein 52
    ribosomal oxygenase MINA

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042533.2NP_001035998.1  ribosomal oxygenase 2 isoform a

      See identical proteins and their annotated locations for NP_001035998.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (A). Variants 1 and 2 encode the same protein (isoform A).
      Source sequence(s)
      AC110491, AL550737, AY302110, DA310030
      Consensus CDS
      CCDS43114.1
      UniProtKB/Swiss-Prot
      Q8IUF8
      Related
      ENSP00000328251.6, ENST00000333396.11
      Conserved Domains (1) summary
      pfam08007
      Location:52364
      Cupin_4; Cupin superfamily protein
    2. NM_001261829.1NP_001248758.1  ribosomal oxygenase 2 isoform b

      See identical proteins and their annotated locations for NP_001248758.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses alternate splice sites in the 5' UTR and 3' coding region, compared to variant 1, and encodes a shorter protein (isoform B), compared to isoform A. Variants 3 and 4 encode the same protein (isoform B).
      Source sequence(s)
      AC026100, AC110491, AK027299, DA310030
      Consensus CDS
      CCDS2929.1
      UniProtKB/Swiss-Prot
      Q8IUF8
      Conserved Domains (1) summary
      pfam08007
      Location:52363
      Cupin_4; Cupin superfamily protein
    3. NM_032778.5NP_116167.3  ribosomal oxygenase 2 isoform b

      See identical proteins and their annotated locations for NP_116167.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, compared to variant 1, and encodes a shorter protein (isoform B), compared to isoform A. Variants 3 and 4 encode the same protein (isoform B).
      Source sequence(s)
      AB083190, AC026100, AC110491, AL550737, DA310030
      Consensus CDS
      CCDS2929.1
      UniProtKB/Swiss-Prot
      Q8IUF8
      Related
      ENSP00000353395.4, ENST00000360258.8
      Conserved Domains (1) summary
      pfam08007
      Location:52363
      Cupin_4; Cupin superfamily protein
    4. NM_153182.4NP_694822.2  ribosomal oxygenase 2 isoform a

      See identical proteins and their annotated locations for NP_694822.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1, and encodes isoform A. Variants 1 and 2 encode the same protein (isoform A).
      Source sequence(s)
      AC110491, DA310030, DQ453796
      Consensus CDS
      CCDS43114.1
      UniProtKB/Swiss-Prot
      Q8IUF8
      Related
      ENSP00000377748.2, ENST00000394198.7
      Conserved Domains (1) summary
      pfam08007
      Location:52364
      Cupin_4; Cupin superfamily protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      97941817..97972451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005247838.4XP_005247895.1  ribosomal oxygenase 2 isoform X1

      See identical proteins and their annotated locations for XP_005247895.1

      UniProtKB/Swiss-Prot
      Q8IUF8
      Conserved Domains (1) summary
      pfam08007
      Location:52364
      Cupin_4; Cupin superfamily protein
    2. XM_011513244.3XP_011511546.1  ribosomal oxygenase 2 isoform X2

      Conserved Domains (1) summary
      cl21464
      Location:7133
      cupin_like; Conserved domain found in cupin and related proteins

    RNA

    1. XR_001740332.2 RNA Sequence

    2. XR_241516.5 RNA Sequence

    3. XR_001740331.2 RNA Sequence

      Related
      ENST00000514314.5
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