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    NAA11 N-alpha-acetyltransferase 11, NatA catalytic subunit [ Homo sapiens (human) ]

    Gene ID: 84779, updated on 9-Dec-2024

    Summary

    Official Symbol
    NAA11provided by HGNC
    Official Full Name
    N-alpha-acetyltransferase 11, NatA catalytic subunitprovided by HGNC
    Primary source
    HGNC:HGNC:28125
    See related
    Ensembl:ENSG00000156269 MIM:619432; AllianceGenome:HGNC:28125
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARD2; ARD1B; hARD2
    Summary
    Enables peptide alpha-N-acetyltransferase activity. Involved in N-terminal protein amino acid acetylation. Located in several cellular components, including Golgi apparatus; centrosome; and nucleoplasm. Part of NatA complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis (RPKM 1.1) and placenta (RPKM 0.8) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See NAA11 in Genome Data Viewer
    Location:
    4q21.21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (79155376..79326061, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (82491029..82661846, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (80237801..80247215, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene BMP2 inducible kinase Neighboring gene RNA, 7SL, cytoplasmic 127, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15515 Neighboring gene progestin and adipoQ receptor family member 3 Neighboring gene long intergenic non-protein coding RNA 1088 Neighboring gene uncharacterized LOC124900723 Neighboring gene MPRA-validated peak5059 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:80169419-80169920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:80218690-80219258 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:80274106-80274606 Neighboring gene uncharacterized LOC105377300 Neighboring gene glycerol kinase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC10646

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables peptide alpha-N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide-alanine-alpha-N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide-glutamate-alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide-serine-alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in N-terminal protein amino acid acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    part_of NatA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of NatA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of NatA complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
     
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    N-alpha-acetyltransferase 11
    Names
    =N-terminal acetyltransferase complex ARD1 subunit homolog B
    ARD1 homolog B
    N-terminal acetyltransferase complex ARD1 subunit homolog B
    human arrest defective 2
    natA catalytic subunit Naa11
    NP_116082.1
    XP_016864266.1
    XP_016864267.1
    XP_016864268.1
    XP_054207090.1
    XP_054207091.1
    XP_054207092.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032693.3NP_116082.1  N-alpha-acetyltransferase 11

      See identical proteins and their annotated locations for NP_116082.1

      Status: VALIDATED

      Source sequence(s)
      AC023277, BC004552
      Consensus CDS
      CCDS47084.1
      UniProtKB/Swiss-Prot
      Q66K19, Q6P479, Q9BSU3
      Related
      ENSP00000286794.4, ENST00000286794.5
      Conserved Domains (2) summary
      COG0456
      Location:1149
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:47122
      Acetyltransf_1; Acetyltransferase (GNAT) family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      79155376..79326061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008779.2XP_016864268.1  N-alpha-acetyltransferase 11 isoform X1

      UniProtKB/Swiss-Prot
      Q66K19, Q6P479, Q9BSU3
      Conserved Domains (2) summary
      COG0456
      Location:1149
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:47122
      Acetyltransf_1; Acetyltransferase (GNAT) family
    2. XM_017008778.3XP_016864267.1  N-alpha-acetyltransferase 11 isoform X1

      UniProtKB/Swiss-Prot
      Q66K19, Q6P479, Q9BSU3
      Conserved Domains (2) summary
      COG0456
      Location:1149
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:47122
      Acetyltransf_1; Acetyltransferase (GNAT) family
    3. XM_017008777.2XP_016864266.1  N-alpha-acetyltransferase 11 isoform X1

      UniProtKB/Swiss-Prot
      Q66K19, Q6P479, Q9BSU3
      Conserved Domains (2) summary
      COG0456
      Location:1149
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:47122
      Acetyltransf_1; Acetyltransferase (GNAT) family

    RNA

    1. XR_007057978.1 RNA Sequence

    2. XR_001741340.2 RNA Sequence

    3. XR_001741339.2 RNA Sequence

    4. XR_007057977.1 RNA Sequence

    5. XR_007057979.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      82491029..82661846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351117.1XP_054207092.1  N-alpha-acetyltransferase 11 isoform X1

      UniProtKB/Swiss-Prot
      Q66K19, Q6P479, Q9BSU3
    2. XM_054351116.1XP_054207091.1  N-alpha-acetyltransferase 11 isoform X1

      UniProtKB/Swiss-Prot
      Q66K19, Q6P479, Q9BSU3
    3. XM_054351115.1XP_054207090.1  N-alpha-acetyltransferase 11 isoform X1

      UniProtKB/Swiss-Prot
      Q66K19, Q6P479, Q9BSU3

    RNA

    1. XR_008487051.1 RNA Sequence

    2. XR_008487050.1 RNA Sequence