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    USP32 ubiquitin specific peptidase 32 [ Homo sapiens (human) ]

    Gene ID: 84669, updated on 17-Jun-2019

    Summary

    Official Symbol
    USP32provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 32provided by HGNC
    Primary source
    HGNC:HGNC:19143
    See related
    Ensembl:ENSG00000170832 MIM:607740
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    USP10; NY-REN-60
    Expression
    Broad expression in testis (RPKM 36.8), brain (RPKM 14.5) and 23 other tissues See more
    Orthologs

    Genomic context

    See USP32 in Genome Data Viewer
    Location:
    17q23.1-q23.2
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (60177231..60422470, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (58254551..58469586, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100996660 Neighboring gene carbonic anhydrase 4 Neighboring gene family with sequence similarity 106 member D, pseudogene Neighboring gene small Cajal body-specific RNA 20 Neighboring gene septin 7 pseudogene Neighboring gene ribosomal protein L32 pseudogene 32 Neighboring gene uncharacterized LOC105371850 Neighboring gene chromosome 17 open reading frame 64 Neighboring gene ribosomal protein L12 pseudogene 38 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 42

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    protein deubiquitination TAS
    Traceable Author Statement
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 32
    Names
    deubiquitinating enzyme 32
    renal carcinoma antigen NY-REN-60
    ubiquitin specific protease 32
    ubiquitin thioesterase 32
    ubiquitin thiolesterase 32
    ubiquitin-specific-processing protease 32
    NP_115971.2
    XP_011523673.1
    XP_011523674.1
    XP_011523675.1
    XP_011523676.1
    XP_011523677.1
    XP_011523678.1
    XP_011523680.1
    XP_011523681.1
    XP_016880722.1
    XP_016880723.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032582.4NP_115971.2  ubiquitin carboxyl-terminal hydrolase 32

      See identical proteins and their annotated locations for NP_115971.2

      Status: VALIDATED

      Source sequence(s)
      AC025048, AF533230, AL834444, BI459907
      Consensus CDS
      CCDS32697.1
      UniProtKB/Swiss-Prot
      Q8NFA0
      Related
      ENSP00000300896.3, ENST00000300896.9
      Conserved Domains (6) summary
      COG5560
      Location:5181316
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd00051
      Location:237293
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl02553
      Location:12251565
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:519586
      DUSP; DUSP domain
      pfam13499
      Location:236293
      EF-hand_7; EF-hand domain pair
      pfam14836
      Location:623710
      Ubiquitin_3; Ubiquitin-like domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      60177231..60422470 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525372.1XP_011523674.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X2

      Conserved Domains (6) summary
      COG5560
      Location:5341332
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd00051
      Location:253309
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl02553
      Location:12411581
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:535602
      DUSP; DUSP domain
      pfam13499
      Location:252309
      EF-hand_7; EF-hand domain pair
      pfam14836
      Location:639726
      Ubiquitin_3; Ubiquitin-like domain
    2. XM_011525371.1XP_011523673.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X1

      Conserved Domains (6) summary
      COG5560
      Location:5341346
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd00051
      Location:253309
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl02553
      Location:12551595
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:535602
      DUSP; DUSP domain
      pfam13499
      Location:252309
      EF-hand_7; EF-hand domain pair
      pfam14836
      Location:653740
      Ubiquitin_3; Ubiquitin-like domain
    3. XM_011525376.1XP_011523678.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X6

      Conserved Domains (6) summary
      COG5560
      Location:5151313
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd00051
      Location:234290
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl02553
      Location:12221562
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:516583
      DUSP; DUSP domain
      pfam13499
      Location:233290
      EF-hand_7; EF-hand domain pair
      pfam14836
      Location:620707
      Ubiquitin_3; Ubiquitin-like domain
    4. XM_011525374.1XP_011523676.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X4

      Conserved Domains (6) summary
      COG5560
      Location:5151327
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd00051
      Location:234290
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl02553
      Location:12361576
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:516583
      DUSP; DUSP domain
      pfam13499
      Location:233290
      EF-hand_7; EF-hand domain pair
      pfam14836
      Location:634721
      Ubiquitin_3; Ubiquitin-like domain
    5. XM_011525373.1XP_011523675.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X3

      Conserved Domains (6) summary
      COG5560
      Location:5181330
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd00051
      Location:237293
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl02553
      Location:12391579
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:519586
      DUSP; DUSP domain
      pfam13499
      Location:236293
      EF-hand_7; EF-hand domain pair
      pfam14836
      Location:637724
      Ubiquitin_3; Ubiquitin-like domain
    6. XM_011525375.1XP_011523677.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X5

      Conserved Domains (6) summary
      COG5560
      Location:5081320
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd00051
      Location:227283
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl02553
      Location:12291569
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:509576
      DUSP; DUSP domain
      pfam13499
      Location:226283
      EF-hand_7; EF-hand domain pair
      pfam14836
      Location:627714
      Ubiquitin_3; Ubiquitin-like domain
    7. XM_017025233.1XP_016880722.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X8

    8. XM_011525378.1XP_011523680.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X7

      Conserved Domains (6) summary
      COG5560
      Location:4721284
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd00051
      Location:191247
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl02553
      Location:11931533
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:473540
      DUSP; DUSP domain
      pfam13499
      Location:190247
      EF-hand_7; EF-hand domain pair
      pfam14836
      Location:591678
      Ubiquitin_3; Ubiquitin-like domain
    9. XM_011525379.3XP_011523681.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X9

      Conserved Domains (4) summary
      COG5560
      Location:2271039
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cl02553
      Location:9481288
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:228295
      DUSP; DUSP domain
      pfam14836
      Location:346433
      Ubiquitin_3; Ubiquitin-like domain
    10. XM_017025234.1XP_016880723.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X10

      Related
      ENSP00000467885.1, ENST00000592339.5
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