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    SPINK7 serine peptidase inhibitor Kazal type 7 [ Homo sapiens (human) ]

    Gene ID: 84651, updated on 18-Sep-2024

    Summary

    Official Symbol
    SPINK7provided by HGNC
    Official Full Name
    serine peptidase inhibitor Kazal type 7provided by HGNC
    Primary source
    HGNC:HGNC:24643
    See related
    Ensembl:ENSG00000145879 MIM:617288; AllianceGenome:HGNC:24643
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ECG2; ECRG2
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward esophagus (RPKM 102.7) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SPINK7 in Genome Data Viewer
    Location:
    5q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (148312423..148315919)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (148846934..148850430)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (147691986..147695482)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene FBXO38 divergent transcript Neighboring gene serine peptidase inhibitor Kazal type 13 Neighboring gene piggyBac transposable element derived 4 pseudogene 3 Neighboring gene serine peptidase inhibitor Kazal type 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23363 Neighboring gene F-box protein 38 Neighboring gene PRELI domain containing 3B pseudogene 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC133105, MGC133106

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cytokine production involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine protease inhibitor Kazal-type 7
    Names
    ECRG-2
    esophagus cancer-related gene 2 protein
    esophagus cancer-related gene-2
    serine peptidase inhibitor, Kazal type 7 (putative)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032566.3NP_115955.1  serine protease inhibitor Kazal-type 7 precursor

      See identical proteins and their annotated locations for NP_115955.1

      Status: VALIDATED

      Source sequence(s)
      AC091948, AF268198, AY359072
      Consensus CDS
      CCDS4289.1
      UniProtKB/Swiss-Prot
      P58062, Q32LY0
      Related
      ENSP00000274565.4, ENST00000274565.5
      Conserved Domains (1) summary
      cd01327
      Location:4185
      KAZAL_PSTI; Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      148312423..148315919
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      148846934..148850430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)