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    IL1F10 interleukin 1 family member 10 [ Homo sapiens (human) ]

    Gene ID: 84639, updated on 23-Dec-2018

    Summary

    Official Symbol
    IL1F10provided by HGNC
    Official Full Name
    interleukin 1 family member 10provided by HGNC
    Primary source
    HGNC:HGNC:15552
    See related
    Ensembl:ENSG00000136697 MIM:615296
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IL-38; FKSG75; IL1HY2; IL-1HY2; IL1-theta; FIL1-theta
    Summary
    The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward skin (RPKM 1.0) See more
    Orthologs

    Genomic context

    See IL1F10 in Genome Data Viewer
    Location:
    2q14.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (113067970..113075850)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113825547..113833427)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene interleukin 36 beta Neighboring gene interleukin 36 receptor antagonist Neighboring gene RNA, U6 small nuclear 1180, pseudogene Neighboring gene interleukin 1 receptor antagonist

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies protein quantitative trait loci (pQTLs).
    NHGRI GWA Catalog
    Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
    NHGRI GWA Catalog
    Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
    NHGRI GWA Catalog
    Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC119831, MGC119832, MGC119833

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    interleukin-1 receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to cytokine stimulus TAS
    Traceable Author Statement
    more info
     
    cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of interleukin-6 production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    interleukin-1 family member 10
    Names
    FIL1 theta
    IL-1 theta
    IL-1F10 (canonical form IL-1F10a)
    family of interleukin 1-theta
    interleukin 1 family member 10 (theta)
    interleukin-1 HY2
    interleukin-1 receptor antagonist FKSG75
    interleukin-1 receptor antagonist-like FIL1 theta
    interleukin-38

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032556.5NP_115945.4  interleukin-1 family member 10

      See identical proteins and their annotated locations for NP_115945.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. It differs in the 5' UTR compared to variant 2. Both variants encode the same protein.
      Source sequence(s)
      AC016724, AF334755, AY358846
      Consensus CDS
      CCDS2112.1
      UniProtKB/Swiss-Prot
      Q8WWZ1
      Related
      ENSP00000376893.2, ENST00000393197.2
      Conserved Domains (1) summary
      cl00094
      Location:10149
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    2. NM_173161.2NP_775184.1  interleukin-1 family member 10

      See identical proteins and their annotated locations for NP_775184.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AY029413, AY358846
      Consensus CDS
      CCDS2112.1
      UniProtKB/Swiss-Prot
      Q8WWZ1
      Related
      ENSP00000341794.2, ENST00000341010.6
      Conserved Domains (1) summary
      cl00094
      Location:10149
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      113067970..113075850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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