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    CUL1 cullin 1 [ Homo sapiens (human) ]

    Gene ID: 8454, updated on 5-May-2024

    Summary

    Official Symbol
    CUL1provided by HGNC
    Official Full Name
    cullin 1provided by HGNC
    Primary source
    HGNC:HGNC:2551
    See related
    Ensembl:ENSG00000055130 MIM:603134; AllianceGenome:HGNC:2551
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Located in plasma membrane. Part of Parkin-FBXW7-Cul1 ubiquitin ligase complex and SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 55.7), lymph node (RPKM 17.7) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CUL1 in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (148697756..148801110)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (149879652..149982884)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (148394848..148498202)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene huntingtin interacting protein K pseudogene Neighboring gene acyl-CoA thioesterase 13 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:148388173-148388399 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26800 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:148396297-148397022 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:148469244-148470443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26801 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148479522-148480224 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:148480425-148481624 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:148495129-148496328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:148504832-148505332 Neighboring gene RNA, U7 small nuclear 20 pseudogene Neighboring gene enhancer of zeste 2 polycomb repressive complex 2 subunit Neighboring gene Sharpr-MPRA regulatory region 2848 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:148580637-148581328 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18737 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18738 Neighboring gene uncharacterized LOC124901767

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with Cullin 1 (CUL1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC149834, MGC149835

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin ligase complex scaffold activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of cullin-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IC
    Inferred by Curator
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_065171.1 RefSeqGene

      Range
      6148..108355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1407

    mRNA and Protein(s)

    1. NM_001370660.1NP_001357589.1  cullin-1

      Status: REVIEWED

      Source sequence(s)
      AC005229, AC006323
      Consensus CDS
      CCDS34772.1
      UniProtKB/Swiss-Prot
      D3DWG3, O60719, Q08AL6, Q13616, Q8IYW1
      UniProtKB/TrEMBL
      A0A090N7U0, A0A590UJ21, A0A590UJR3
      Related
      ENSP00000499277.1, ENST00000662716.1
      Conserved Domains (2) summary
      pfam00888
      Location:21660
      Cullin; Cullin family
      pfam10557
      Location:706767
      Cullin_Nedd8; Cullin protein neddylation domain
    2. NM_001370661.1NP_001357590.1  cullin-1

      Status: REVIEWED

      Source sequence(s)
      AC005229, AC006323
      Consensus CDS
      CCDS34772.1
      UniProtKB/Swiss-Prot
      D3DWG3, O60719, Q08AL6, Q13616, Q8IYW1
      UniProtKB/TrEMBL
      A0A090N7U0, A0A590UJ21, A0A590UJR3
      Related
      ENSP00000499255.1, ENST00000665936.1
      Conserved Domains (2) summary
      pfam00888
      Location:21660
      Cullin; Cullin family
      pfam10557
      Location:706767
      Cullin_Nedd8; Cullin protein neddylation domain
    3. NM_001370662.1NP_001357591.1  cullin-1

      Status: REVIEWED

      Source sequence(s)
      AC005229, AC006323
      Consensus CDS
      CCDS34772.1
      UniProtKB/Swiss-Prot
      D3DWG3, O60719, Q08AL6, Q13616, Q8IYW1
      UniProtKB/TrEMBL
      A0A090N7U0, A0A590UJ21, A0A590UJR3
      Related
      ENSP00000473318.1, ENST00000602748.5
      Conserved Domains (2) summary
      pfam00888
      Location:21660
      Cullin; Cullin family
      pfam10557
      Location:706767
      Cullin_Nedd8; Cullin protein neddylation domain
    4. NM_001370663.1NP_001357592.1  cullin-1

      Status: REVIEWED

      Source sequence(s)
      AC005229, AC006323
      Consensus CDS
      CCDS34772.1
      UniProtKB/Swiss-Prot
      D3DWG3, O60719, Q08AL6, Q13616, Q8IYW1
      UniProtKB/TrEMBL
      A0A090N7U0, A0A590UJ21, A0A590UJR3
      Related
      ENSP00000499398.1, ENST00000663044.1
      Conserved Domains (2) summary
      pfam00888
      Location:21660
      Cullin; Cullin family
      pfam10557
      Location:706767
      Cullin_Nedd8; Cullin protein neddylation domain
    5. NM_001370664.1NP_001357593.1  cullin-1

      Status: REVIEWED

      Source sequence(s)
      AC005229, AC006323
      Consensus CDS
      CCDS34772.1
      UniProtKB/Swiss-Prot
      D3DWG3, O60719, Q08AL6, Q13616, Q8IYW1
      UniProtKB/TrEMBL
      A0A090N7U0, A0A590UJ21, A0A590UJR3
      Conserved Domains (2) summary
      pfam00888
      Location:21660
      Cullin; Cullin family
      pfam10557
      Location:706767
      Cullin_Nedd8; Cullin protein neddylation domain
    6. NM_003592.3NP_003583.2  cullin-1

      See identical proteins and their annotated locations for NP_003583.2

      Status: REVIEWED

      Source sequence(s)
      AF062536, AK096163, CA945052
      Consensus CDS
      CCDS34772.1
      UniProtKB/Swiss-Prot
      D3DWG3, O60719, Q08AL6, Q13616, Q8IYW1
      UniProtKB/TrEMBL
      A0A090N7U0, A0A590UJ21, A0A590UJR3
      Related
      ENSP00000326804.3, ENST00000325222.9
      Conserved Domains (2) summary
      pfam00888
      Location:21660
      Cullin; Cullin family
      pfam10557
      Location:706767
      Cullin_Nedd8; Cullin protein neddylation domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      148697756..148801110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      149879652..149982884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)