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    Klf5 KLF transcription factor 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84410, updated on 2-Nov-2024

    Summary

    Official Symbol
    Klf5provided by RGD
    Official Full Name
    KLF transcription factor 5provided by RGD
    Primary source
    RGD:621446
    See related
    EnsemblRapid:ENSRNOG00000008785 AllianceGenome:RGD:621446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    IKLF; Bteb2; bteb2
    Summary
    Enables sequence-specific DNA binding activity. Involved in cellular response to organic cyclic compound; cellular response to peptide; and positive regulation of cell population proliferation. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be part of transcription regulator complex. Used to study transient cerebral ischemia. Orthologous to human KLF5 (KLF transcription factor 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 73.0), Muscle (RPKM 30.3) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Klf5 in Genome Data Viewer
    Location:
    15q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (82472081..82487267)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (76060320..76079445)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (83703796..83722921)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene bora, aurora kinase A activator Neighboring gene Spi-C transcription factor, pseudogene 2 Neighboring gene DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene U6 spliceosomal RNA Neighboring gene serpin family B member 6 like, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell signaling via exosome ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to peptide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within intestinal epithelial cell development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of microvillus assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within myotube differentiation involved in skeletal muscle regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by transcription factor localization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of regulation of microvillus assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within satellite cell activation involved in skeletal muscle regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skeletal muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skeletal muscle satellite cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skeletal muscle tissue regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    Krueppel-like factor 5
    Names
    Kruppel-like factor 5 (intestinal)
    basic transcription element binding protein 2
    basic transcription element binding protein BTEB2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053394.3NP_445846.3  Krueppel-like factor 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      F1LSL7, Q66HP1
      Related
      ENSRNOP00000054653.2, ENSRNOT00000057843.4
      Conserved Domains (5) summary
      COG5048
      Location:345419
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:361383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:419441
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:405430
      zf-H2C2_2; Zinc-finger double domain
      cd21579
      Location:3356
      KLF5_N; N-terminal domain of Kruppel-like factor 5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      82472081..82487267
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)