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    KATNAL1 katanin catalytic subunit A1 like 1 [ Homo sapiens (human) ]

    Gene ID: 84056, updated on 11-Apr-2024

    Summary

    Official Symbol
    KATNAL1provided by HGNC
    Official Full Name
    katanin catalytic subunit A1 like 1provided by HGNC
    Primary source
    HGNC:HGNC:28361
    See related
    Ensembl:ENSG00000102781 MIM:614764; AllianceGenome:HGNC:28361
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables identical protein binding activity and microtubule-severing ATPase activity. Involved in microtubule severing. Located in cytoplasm; microtubule; and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 4.9), brain (RPKM 4.4) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    13q12.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (30202630..30307551, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (29425152..29530029, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (30776767..30881688, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:30727396-30728595 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7531 Neighboring gene long intergenic non-protein coding RNA 384 Neighboring gene long intergenic non-protein coding RNA 385 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:30752927-30753673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:30753674-30754419 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5227 Neighboring gene uncharacterized LOC102723381 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:30831661-30832161 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:30860016-30860638 Neighboring gene RNA, U6 small nuclear 64, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5229 Neighboring gene peroxiredoxin 2 pseudogene 1 Neighboring gene uncharacterized LOC124903145 Neighboring gene long intergenic non-protein coding RNA 427 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:30912012-30913211 Neighboring gene long intergenic non-protein coding RNA 426

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.
    EBI GWAS Catalog
    Genetically distinct subsets within ANCA-associated vasculitis.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC2599

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule severing ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in microtubule severing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule severing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of katanin complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule cytoskeleton NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    katanin p60 ATPase-containing subunit A-like 1
    Names
    katanin catalytic subunit A like 1
    katanin p60 subunit A like 1
    p60 katanin-like 1
    NP_001014402.1
    NP_115492.1
    XP_005266631.1
    XP_016876282.1
    XP_024305191.1
    XP_024305192.1
    XP_047286659.1
    XP_047286660.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014380.3NP_001014402.1  katanin p60 ATPase-containing subunit A-like 1

      See identical proteins and their annotated locations for NP_001014402.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK097423, AL356750, BC000612
      Consensus CDS
      CCDS31956.1
      UniProtKB/Swiss-Prot
      A8K5X4, Q9BW62
      UniProtKB/TrEMBL
      B2RDY3, B3KUK7
      Related
      ENSP00000369991.3, ENST00000380617.7
      Conserved Domains (1) summary
      COG0464
      Location:188483
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    2. NM_032116.5NP_115492.1  katanin p60 ATPase-containing subunit A-like 1

      See identical proteins and their annotated locations for NP_115492.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL356750, BC000612, DR006891
      Consensus CDS
      CCDS31956.1
      UniProtKB/Swiss-Prot
      A8K5X4, Q9BW62
      UniProtKB/TrEMBL
      B2RDY3, B3KUK7
      Related
      ENSP00000369989.3, ENST00000380615.8
      Conserved Domains (1) summary
      COG0464
      Location:188483
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      30202630..30307551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449424.2XP_024305192.1  katanin p60 ATPase-containing subunit A-like 1 isoform X1

      UniProtKB/Swiss-Prot
      A8K5X4, Q9BW62
      UniProtKB/TrEMBL
      B2RDY3, B3KUK7
      Conserved Domains (1) summary
      COG0464
      Location:188483
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    2. XM_005266574.4XP_005266631.1  katanin p60 ATPase-containing subunit A-like 1 isoform X1

      See identical proteins and their annotated locations for XP_005266631.1

      UniProtKB/Swiss-Prot
      A8K5X4, Q9BW62
      UniProtKB/TrEMBL
      B2RDY3, B3KUK7
      Conserved Domains (1) summary
      COG0464
      Location:188483
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    3. XM_024449423.2XP_024305191.1  katanin p60 ATPase-containing subunit A-like 1 isoform X1

      UniProtKB/Swiss-Prot
      A8K5X4, Q9BW62
      UniProtKB/TrEMBL
      B2RDY3, B3KUK7
      Conserved Domains (1) summary
      COG0464
      Location:188483
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    4. XM_047430703.1XP_047286659.1  katanin p60 ATPase-containing subunit A-like 1 isoform X1

      UniProtKB/Swiss-Prot
      A8K5X4, Q9BW62
    5. XM_047430704.1XP_047286660.1  katanin p60 ATPase-containing subunit A-like 1 isoform X2

    6. XM_017020793.3XP_016876282.1  katanin p60 ATPase-containing subunit A-like 1 isoform X2

      Conserved Domains (1) summary
      COG0464
      Location:20315
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      29425152..29530029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)